Publications

Kell DB, Khan MA, Laubscher G J and Pretorius E. (2023) The aetiological involvement of fibrin amyloid microclots in PASC/Long COVID. submitted.

Pretorius, E, Kell, DB (2023) A perspective on how microscopy imaging of fibrinaloid microclots and platelet pathology may be applied in clinical investigations. Semin Thromb Haemost . DOI 10.1055/s-0043-1774796.

Roberts I, Wright Muelas M, Taylor JM, Davison AS, Winder CL, Goodacre R, Kell DB (2023) Quantitative LC-MS study of compounds found predictive of COVID-19 severity and outcome Metabolomics 19, 87. DOI: 10.1007/s11306-023-02048-0. medRxiv preprint 2023:2023.2003.2017.23287401.

Kell DB, Pretorius E (2023) Are fibrinaloid microclots a cause of autoimmunity in Long Covid and other post-infection diseases? Biochem J 480, 1217-1240. DOI:  10.1042/BCJ20230241.

Pannu HS, Kell DB (2023) Hyperparameter optimisation in differential evolution using Summed Local Difference Strings, a rugged but easily calculated landscape for combinatorial search problems. bioRxiv 2023.07.11.548503v1. Preprint DOI 10.1101/2023.07.11.548503.

Turner S, Laubscher GJ, Khan MA, Kell DB, Pretorius E (2023) Accelerating discovery: A novel flow cytometric method for detecting fibrin(ogen) amyloid microclots using long COVID as a model. Heliyon 9, e19605. DOI: 10.1016/j.heliyon.2023.e19605.  Preprint here. Also here.

Laubscher GJ, Khan MA, Venter C, Pretorius JH, Kell DB, Pretorius E (2023) Treatment of Long COVID symptoms with triple anticoagulant therapy. Submitted. Preprint here.

Kenny LC, Brown LW, Ortea P, Tuytten R, Kell DB (2023) Relationship between the concentration of ergothioneine in plasma and the likelihood of developing pre-eclampsia. Biosci Rep 43, BSR20230160. doi: 10.1042/bsr20230160. PMID 37278746. Preprint (2022) medRxiv 2022.2012.2019.22283617. Preprint DOI: 10.1101/2022.12.19.22283617.

Oladejo SO, Watson LR, Watson BW, Rajaratnam K, Kotze MJ, Kell DB, Pretorius E (2023) Data sharing: A Long COVID perspective, challenges, and road map for the future. South Afr J Sci 119, 1-8. DOI: 10.17159/sajs.2023/14719.

Turner S, Khan MA, Putrino D, Woodcock A, Kell DB, Pretorius E (2023) Long COVID: pathophysiological factors and abnormalities of coagulation. Trends Endocrinol Metab 34, 321-344. DOI: 10.1016/j.tem.2023.03.002.

Nunes JM, Kell DB, Pretorius E (2023) Cardiovascular and haematological pathology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): a role for viruses. Blood Rev 60, 101075. DOI: 10.1016/j.blre.2023.101075.

Grobler C, van Tongeren M, Gettemans J, Kell DB Pretorius E (2023) Alzheimer-type dementia: a systems view provides a unifying explanation of its development. J Alz Dis 91, 43-70. DOI: 10.3233/JAD-220720.

Glenn SM, Turapov O, Makarov V, Kell DB, Mukamolova GV (2022) Dimethyl fumarate eliminates differentially culturable Mycobacterium tuberculosis in an intranasal murine model of tuberculosis. Frontiers Cell Infect Microbiol 12,  957287. DOI: 10.3389/fcimb.2022.957297.

Kruger A, Vlok M, Turner S, Venter C, Laubscher GJ, Kell DB, Pretorius E (2022) Proteomics of fibrin amyloid microclots in Long COVID/ Post-Acute Sequelae of COVID-19 (PASC) shows many entrapped pro-inflammatory molecules that may also contribute to a failed fibrinolytic system. Cardiovasc Diabetol 21, 190. DOI 10.1186/s12933-022-01623-4.

Kell DB, Pretorius E (2022) The potential role of ischaemia-reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, long COVID and ME/CFS: evidence, mechanisms, and therapeutic implications. Biochem J 479, 1653-1709. DOI: 10.1042/BCJ20220154

Grobbelaar LM, Kruger A, Venter C, Burger EM, Laubscher GJ, Maponga TG, Kotze MJ, Kwaan HC, Miller JB, Fulkerson D, Huff W, Chang E, Wiarda G, Bunch CM, Walsh MM, Raza S, Zamlut M, Moore HB, Moore EE, Neal M, Kell DB, Pretorius E (2022) Relative hypercoagulopathy of the SARS-CoV-2 Beta and Delta variants when compared to the less severe Omicron variants is related to TEG parameters, the extent of fibrin amyloid microclots, and the severity of clinical illness. Semin Thromb Hemost 48, 858-868. DOI: 10.1055/s-0042-1756306. ResearchSquare preprint here.

Munro LJ, Kell DB (2022) Analysis of a library of E. coli transporter knockout strains to identify transport pathways of antibiotics. Antibiotics 11, 1129. DOI: 10.3390/antibiotics11081129.

Pretorius E, Venter C, Laubscher GJ, Kotze MJ, Oladejo S, Watson LR, Rajaratnam K, Watson BW, Kell DB (2022) Prevalence of symptoms, comorbidities, fibrin amyloid microclots and platelet pathology in individuals with Long COVID/ Post-Acute Sequelae of COVID-19 (PASC). Cardiovasc Diabetol. 21, 148. DOI: 10.1186/s12933-022-01579-5. Research Square Preprint at https://www.researchsquare.com/article/rs-1205453/v2. DOI: 10.21203/rs.21203.rs-1205453/v1205452.

Nunes JM, Kruger A, Proal A, Kell DB, Pretorius E (2022) The occurrence of hyperactivated platelets and fibrinaloid microclots in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Pharmaceuticals 15, 931. DOI: 10.3390/ph15080931.  Preprint at Research Square. Updated v2. DOI: 10.21203/rs.3.rs-1727226/v1.

Yang L, Malla S, Özdemir E, Kim SH, Lennen R, Christensen HB, Christensen U, Munro LJ, Herrgård MJ, Kell DB, Palsson BØ (2022) Identification and engineering of transporters for efficient melatonin production in Escherichia coli. Frontiers Microbiol 13, 880847. DOI: 10.3389/fmicb.2022.880847.

Sadler JC, Swainston N, Dunstan MS, Currin A, Kell DB: SpeedyGenesXL: an Automated, High-Throughput Platform for the Preparation of Bespoke Ultralarge Variant Libraries for Directed Evolution. Methods Mol Biol 2022; 2461:67-83. DOI: 10.1007/978-1-0716-2152-3_5.

van der Hoek SA, Rusnák M, Jacobsen IH, Martínez JL, Kell DB, Borodina I (2022) Engineering ergothioneine production in Yarrowia lipolytica. FEBS Lett. 596, 1356-1364. Pubmed 34817066. DOI: 10.1002/1873-3468.14239

Radi MS, Sora JES, Kim SH, Sudarsan S, Sastry AV, Kell DB, Herrgård MJ, Feist AM (2022) Membrane transporter identification and modulation via adaptive laboratory evolution. Metab Eng 72, 376-390. DOI: 10.1016/j.ymben.2022.05.004

Bunch CM, Moore EE, Moore HB, Neal MD, Thomas AV, Zackariya N, Zhao J, Zackariya S, Brenner TJ, Berquist M, Buckner H, Wiarda G, Fulkerson D, Huff W, Kwaan HC, Lankowicz G, Laubscher GJ, Lourens PJ, Pretorius E, Kotze MJ, Moolla MS, Sithole S, Maponga TG, Kell DB, Fox M, Gillespie L, Khan RZ, Mamczak CN, March R, Macias R, Bull BS, Walsh MM (2022) Immuno-thrombotic Complications of COVID-19: Implications for Timing of Surgery and Anticoagulation. Front Surg 9, 889999. DOI: 10.3389/fsurg.2022.889999.

Kell DB, Laubscher GJ, Pretorius E (2022) A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications. Biochem J 479, 537-559. DOI: 10.1042/BCJ20220016.

Page MJ, Kell DB, Pretorius E (2022) The role of lipopolysaccharide-induced cell signalling in chronic inflammation. Chronic Stress 6, 1-18.  DOI: 10.1177/24705470221076390.

van der Hoek SA, Rusnák M, Wang G, Stanchev LD, de Fátima Alvez L, Jessop-Fabre MM, Paramasivan K, Jacobsen IH, Sonnenschein N, Martínez JL, Darbani B, Kell DB, Borodina I (2022) Engineering precursor supply for the high-level production of ergothioneine in Saccharomyces cerevisiae. Metab Eng 70:129-142. DOI: j.ymben.2022.01.012.

Roberts I, Wright Muelas M, Taylor JM, Davison AS, Xu Y, Grixti JM, Gotts N, Sorokin A, Goodacre R, Kell DB (2022)  Untargeted metabolomics of COVID-19 patient serum reveals potential prognostic markers of both severity and outcome. Metabolomics 18, 6 (preprint below, 2020). DOI: 10.1007/s11306-021-01859-3

Møller-Hansen I, Sáez-Sáez J, van der Hoek SA, Dyekjær JD, Christensen HB, Wright Muelas M, O’Hagan S, Kell DB, Borodina I (2021). Screening of a focused transporter library for activity towards xenobiotic substrates in yeast and human. Submitted.

Shrivastava AD, Swainston N, Samanta S, Roberts I, Wright Muelas M, Kell DB (2021). Shrivastava AD, Swainston N, Samanta S, Roberts I, Wright Muelas M, Kell DB: MassGenie: a transformer-based deep learning method for identifying small molecules from their mass spectra. Biomolecules 11, 1793. DOI: 10.3390/biom11121793. Preprint at MassGenie: a transformer-based deep learning method for identifying small molecules from their mass spectra. bioRxiv 2021:2021.2006.2025.449969. Also at Shrivastava AD, Swainston N, Samanta S, Roberts I, Wright Muelas M, Kell DB: MassGenie: a transformer-based deep learning method for identifying small molecules from their mass spectra. Preprints 2021:2021100355.

Laubscher GJ, Lourens PJ, Venter C, Kell DB, Pretorius E (2021) TEG^®, microclot and platelet mapping for guiding early management of severe COVID-19 coagulopathy. J Clin Med 10, 5381. DOI: 10.3390/jcm10225381.

Munro LJ, Kell DB (2021) Intelligent host engineering for metabolic flux optimisation in biotechnology. Biochem J 478, 3685-3721. DOI: 10.1042/BCJ20210535.

Salcedo-Sora JE, Robison ATR, Zaengle-Barone J, Franz KJ, Kell DB (2021). Membrane transporters involved in the antimicrobial activities of pyrithione in Escherichia coli. Molecules 26, 5826. DOI: 10.3390/molecules26195826.

Kell DB (2021) The transporter-mediated cellular uptake and efflux of pharmaceutical drugs and biotechnology products: how and why phospholipid bilayer transport is negligible in real biomembranes. Molecules 26, 5629 (40pp). DOI: 10.3390/molecules26185629.

Pretorius E, Vlok M, Venter C, Bezuidenhout JA, Laubscher GJ, Steenkamp J, Kell DB (2021). Persistent clotting protein pathology in Long COVID/ Post-Acute Sequelae of COVID-19 (PASC) is accompanied by increased levels of antiplasmin. Cardiovasc Diabetol 20, 172. Pubmed 34425843. DOI: https://doi.org/10.1186/s12933-021-01359-7. Preprint: Pretorius E, Vlok M, Venter C, Bezuidenhout JA, Laubscher GJ, Steenkamp J, Kell DB (2021). Persistent clotting protein pathology in Long COVID/ Post-Acute Sequelae of COVID-19 (PASC) is accompanied by increased levels of antiplasmin. medRxiv 2021:2021.2005.2021.21257578.

Grobbelaar LM, Venter C, Vlok M, Ngoepe M, Laubscher GJ, Lourens PJ, Steenkamp J, Kell DB, Pretorius E (2021). Grobbelaar LM, Venter C, Vlok M, Ngoepe M, Laubscher GJ, Lourens PJ, Steenkamp J, Kell DB, Pretorius E (2021) SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to fibrinolysis: implications for microclot formation in COVID-19. Biosci Rep 41, BSR20210611. DOI: 10.1042/BSR20210611. Preprint at SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to fibrinolysis: Implications for microclot formation in COVID-19. medRxiv 2021.03.05.21252960v1. Doi: https://doi.org/10.1101/2021.03.05.21252960.

Dvorak V, Wiedmer T, Ingles-Prieto A, Altermatt P, Batoulis H, Bärenz F, Bender E, Digles D, Dürrenberger F, Heitman LH, IJzerman AP, Kell DB, Kickinger S, Körzö D, Leippe P, Licher T, Manolova V, Rizzetto R, Sassone F, Scarabottolo L, Schlessinger A, Schneider V, Sijben HJ, Steck A-L, Sundström H, Tremolada S, Wilhelm M, Wright Muelas M, Zindel D, Steppan CM, Superti-Furga G (2021) An Overview of Cell-Based Assay Platforms for the Solute Carriers Family of Transporters. Front Pharmacol 12, 722889. DOI: 10.3389/fphar.2021.722889.

Lima C, Theron C, Muhamadali H, Kell DB, Goodacre R (2021) Spectral artefacts induced by moving targets in live hyperspectral stimulated Raman spectroscopy: the case of lipid droplets in yeast cells. Clin Spectrosc 3, 100014. DOI: 10.1016/j.clispe.2021.100014.

Kell DB (2021) A protet-based, protonic charge transfer model of energy coupling in oxidative and photosynthetic phosphorylation. Adv Micr Physiol 78:1-177. DOI: 10.1016/bs.ampbs.2021.01.001. A 2020 preprint is: A protet-based, protonic charge transfer model of energy coupling in oxidative and photosynthetic phosphorylation. OSF preprint http://osf.io/2xsz8. Link here to a 7-minute scientific animation.

Wang G, Kell DB, Borodina I (2021): Harnessing the yeast Saccharomyces cerevisiae for the production of fungal secondary metabolites. Essays Biochem EBC20200137. DOI: 10.1042/EBC20200137.

Shrivastava AD, Kell DB (2021). FragNet, a contrastive learning-based transformer model for clustering, interpreting, visualising and navigating chemical space. Molecules 26, 2065. DOI: 10.3390/molecules26072065. Preprint at Preprints 2021, 2021030118

Salcedo-Sora JE, Jindal S, O’Hagan S, Kell DB (2021) A palette of fluorophores that are differentially accumulated by wild-type and mutant strains of Escherichia coli: surrogate ligands for bacterial membrane transporters. Microbiology 167, 001016. DOI: 10.1099/mic.0.001016. Pubmed 33406033. Preprint (2020) at  A palette of fluorophores that are differentially accumulated by wild-type and mutant strains of Escherichia coli: surrogate ligands for bacterial membrane transporters. bioRxiv 152629v1. DOI: 10.1101/2020.06.15.152629.

van Vuuren MJ, Nell TA, Carr JA, Kell DB, Pretorius E (2021).  Iron dysregulation and inflammagens related to oral and gut health are central to the development of Parkinson’s disease. Biomolecules 11, 30. DOI: 10.3390/biom11010030.  Preprint here.

Jiang X, Palazzotto E, Wybraniec E, Munro LJ, Zhang H, Kell DB, Weber T, Lee SY (2020). Automating cloning by natural transformation. ACS Syn Bio, 9, 3228-3235. DOI: 10.1021/acssynbio.0c00240.

Kell DB, Samanta S, Swainston N (2020). Deep learning and generative methods in cheminformatics and chemical biology: navigating small molecule space intelligently. Biochem J 477, 4559-4580. DOI: 10.1042/BCJ20200781.

Bezuidenhout J, Venter C, Roberts T, Tarr G, Kell D, Pretorius E (2020. Detection of citrullinated fibrin in plasma clots of RA patients and its relation to altered structural clot properties, disease-related inflammation and prothrombotic tendency. Front Immunol 11, 577523. DOI 10.3389/fimmu.2020.577523.  bioRxiv link. DOI:10.1101/2020.05.28.121301.

Venter C, Bezuidenhout JA, Laubscher GJ, Lourens PJ, Steenkamp J, Kell DB, Pretorius E (2020). Erythrocyte, platelet, serum ferritin and P-selectin pathophysiology implicated in severe hypercoagulation and vascular complications in COVID-19. Int J Mol Sci 21, 8234. DOI: 10.3390/ijms21218234.

Borodina I, Kell DB, Van Der Hoek S, Darbani SB (2020): Methods for production of ergothioneine. Patent WO2020221795

Kell DB, Yang L, Malla S (2020) Engineered cells for production of indole-derivatives. Patent WO2020187739.

O’Hagan S, Kell DB (2020). Structural similarities between some common fluorophores used in biology, marketed drugs, endogenous metabolites, and natural products. Marine Drugs 18, 582. DOI: 10.3390/md18110582. O’Hagan S, Kell DB (2019). Structural similarities between some common fluorophores used in  biology and marketed drugs, endogenous metabolites, and natural products. bioRxiv:834325v1. DOI:10.1101/834325

Wright Muelas M, Roberts I, Mughal F, O’Hagan S, Day PJ, Kell DB (2020) An untargeted metabolomics strategy to measure differences in metabolite uptake and excretion by mammalian cell lines. Metabolomics 16:107. DOI: 10.1007/s11306-020-01725-8. Preprint: Wright Muelas M, Gueorguieva I, Mughal F, O’Hagan S, Day PJ, Kell DB (2020). An untargeted metabolomics strategy to measure differences in metabolite uptake and excretion by mammalian cell lines. bioRxiv 129239

Keating SM, Waltemath D, Konig M, Zhang F, Drager A, Chaouiya C, Bergmann FT, Finney A, Gillespie CS, Helikar T, Hoops S, Malik-Sheriff RS, Moodie SL, Moraru, II, Myers CJ, Naldi A, Olivier BG, Sahle S, Schaff JC, Smith LP, Swat MJ, Thieffry D, Watanabe L, Wilkinson DJ, Blinov ML, Begley K, Faeder JR, Gómez HF, Hamm TM, Inagaki Y, Liebermeister W, Lister AL, Lucio D, Mjolsness E, Proctor CJ, Raman K, Rodriguez N, Shaffer CA, Shapiro BE, Stelling J, Swainston N, Tanimura N, Wagner J, Meier-Schellersheim M, Sauro HM, Palsson B, Bolouri H, Kitano H, Funahashi A, Hermjakob H, Doyle JC, Hucka M, SBML Level 3 Community members (2020). SBML Level 3: an extensible format for the exchange and reuse of biological models. Mol Syst Biol 16:e9110. DOI: 10.15252/msb.20199110.

Khemchandani Y, O’Hagan S, Samanta S, Swainston N, Roberts TJ, Bollegala D, Kell DB (2020) DeepGraphMolGen, a multiobjective, computational strategy for generating molecules with desirable properties: a graph convolution and reinforcement learning approach. J Cheminform 12, 53. DOI 10.1186/s13321-020-00454-3. Preprint at Khemchandani Y, O’Hagan S, Samanta S, Swainston N, Roberts TJ, Bollegala D, Kell D B (2020). DeepGraphMol, a multiobjective, computational strategy for generating molecules with desirable properties: a graph convolution and reinforcement learning approach. bioRxiv, 2020/114165. DOI: 10.1101/2020.05.25.114165.

Salcedo-Sora JE, Kell DB (2020) A Quantitative Survey of Bacterial Persistence in the Presence of Antibiotics: Towards Antipersister Antimicrobial Discovery. Antibiotics 2020; 9:508. DOI: 10.3390/antibiotics9080508.

Pretorius E, Venter C, Laubscher GJ, Lourens PJ, Steenkamp J, Kell DB (2020) Prevalence of readily detected amyloid blood clots in ‘unclotted’ Type 2 Diabetes Mellitus and COVID-19 plasma: A preliminary report. Cardiovasc Diabetol  19, 193. DOI 10.1186/s12933-020-01165-7. Prevalence of amyloid blood clots in COVID-19 plasma. medRxiv 2020.2007.2028.20163543v20163541. DOI 10.1101/2020.07.28.20163543.

Grobler C, Maphumulo SC, Grobbelaar LM, Bredenkamp J, Laubscher J, Lourens PJ, Steenkamp J, Kell DB, Pretorius E. (2020). COVID-19: The Rollercoaster of Fibrin(ogen), D-dimer, von Willebrand Factor, P-selectin and Their Interactions with Endothelial Cells, Platelets and Erythrocytes. Int J Mol Sci 21:5168. DOI: 10.3390/ijms21145168. Preprint at Grobler C, Bredenkamp J, Grobbelaar M, Maphumulo S, Laubscher J, Steenkamp J, Kell DB, Pretorius E (2020): COVID-19: The Rollercoaster of Fibrin(ogen), D-dimer, von Willebrand Factor, P-selectin and their interactions with endothelial cells, platelets and erythrocytes. Preprints.org 2020:202007.200142/v202001.

Samanta S, O’Hagan S, Swainston N, Roberts TJ, Kell DB (2020). VAE-Sim: a novel molecular similarity measure based on a variational autoencoder. Molecules 25, 3446. DOI: 10.3390/molecules25153446. Preprint at bioRxiv 2020:172908. DOI: 10.1101/2020.06.26.172908.

Nunes JM, Fillis T, Page MJ, Venter C, Lancry O, Kell DB, Windberger U, Pretorius E (2020) Gingipain R1 and lipopolysaccharide from Porphyromonas gingivalis have major effects on blood clot morphology and mechanics. Front Immunol. 11, 1551. DOI: 10.3389/fimmu.2020.01551.

Olsen I, Kell DB, Pretorius E (2020). Is Porphyromonas gingivalis involved in Parkinson’s disease? Eur J Clin Microbiol Infect Dis, https://doi.org/10.1007/s10096-020-03944-2. DOI: 10.1007/s10096-020-03944-2.

Kell DB (2020) How drugs really get into cells: why passive bilayer diffusion is a myth. ACS webinar, 55 min + questions, freely available online here . Another version to SCI here.

Kell DB, Heyden EL Pretorius, E. (2020) The biology of lactoferrin, an iron-binding protein that can help defend against viruses and bacteria. FrontiersIn Immunol 11, 1221. DOI: 10.3389/fimmu.2020.01221. OSF Preprints https://osf.io/fxudj/. Online preprint.

Kell DB and colleagues (2020) Ergothioneine: the new super antioxidant. Scientific animation – 2.5 minutes.

Superti-Furga G, Lackner D, Tabea Wiedme, Ingles-Prieto A, Barbosa B, Girardi E, Ulrich Goldman, Gürtl B, Klavins K, Klimek C, Sabrina Lindinge, Liñeiro-Retes E, Müller AC, Onstein S, Gregor Redinge, Reil D, Sedlyarov V, Wolf G, Crawford M, Everley R, Hepworth D, Liu S, Noell S, Piotrowski M, Stanton R, Zhang H, Corallino S, Faedo A, Insidioso M, Maresca G, Redaelli L, Sassone F, Scarabottolo L, Stucchi M, Tarroni P, Tremolada S, Batoulis H, Becker A, Bender E, Chang Y-N, Ehrmann A, Müller-Fahrnow A, Pütter V, Zindel D, Hamilton B, Lenter M, Santacruz D, Viollet C, Whitehurst C, Johnsson K, Leippe P, Baumgarten B, Chang L, Ibig Y, Pfeifer M, Reinhardt J, Schönbett J, Selzer P, Seuwen K, Bettembourg C, Biton B, Czech J, de Foucauld H, Didier M, Licher T, Mikol V, Pommereau A, Puech F, Yaligara V, Edwards A, Bongers BJ, Heitman LH, IJzerman AP, Sijben HJ, van Westen GJP, Grixti J, Kell DB, Mughal F, Swainston N, Wright Muelas M, Bohstedt T, Burgess-Brown N, Carpenter L, Dürr K, Jesper Hanse, Scacioc A, Banci G, Colas C, Daniela Digle, Ecker G, Füzi B, Gamsjäger V, Grandits M, Martini R, Troger F, Altermatt P, Doucerain C, Dürrenberger F, Manolova V, Steck A-L, Sundström H, Wilhelm M, Steppan CM (2020) The RESOLUTE consortium: unlocking SLC transporters for drug discovery. Nat Rev Drug Discov 19, 429-430. online. DOI: 10.1038/d41573-020-00056-6.

Morillon A-C, Williamson RD, Baker PN, Kell DB, Kenny LC, English JA, McCarthy FP, McCarthy C (2020). Effect of L-Ergothioneine on the metabolic plasma profile of the RUPP rat model of pre-eclampsia. PLoSOne 15, e0230977. DOI: 10.1371/journal.pone.0230977. Pubmed 32231385.

Kell DB (2020). Hitchhiking into the cell. Nat Chem Biol 16, 367-368.  DOI: 10.1038/s41589-020-0489-x. Pubmed 32152545. e-access.

Kell DB (2020) A protet-based, protonic charge transfer model of energy coupling in oxidative and photosynthetic phosphorylation. OSF preprint http://osf.io/2xsz8. Link here to a 7-minute scientific animation.

Mendes P, Girardi E, Superti-Furga G, Kell DB (2020): Why most transporter mutations that cause antibiotic resistance are to efflux pumps rather than to import transporters. bioRxiv 2020.2001.2016.909507v909501. DOI 10.1101/2020.01.16.909507.

Borodina I, Kenny LC, McCarthy CM, Paramasivan K, Pretorius R, Roberts TJ, van der Hoek SA, Kell DB (2020). The biology of ergothioneine, an antioxidant nutraceutical. Nutr Res Rev. 33, 190-217.  Pubmed 32051057. DOI: 10.1017/S0954422419000301.

Williamson RD, McCarthy FP, Manna S, Groarke E, Kell DB, Kenny LC, McCarthy CM (2020) L-(+)-Ergothioneine significantly improves the clinical characteristics of preeclampsia in the reduced uterine perfusion pressure rat model. Hypertension 75, 561-568. DOI: 10.1161/HYPERTENSIONAHA.119.13929. Pubmed 31865793.

de Villiers S, Bester J, Kell DB, Pretorius E (2019) Erythrocyte health and the possible role of amyloidogenic blood clotting in the evolving haemodynamics of female migraine-with-aura pathophysiology: Results from a pilot study. Frontiers Neurol 10, 1262.

Wright Muelas, M., Mughal, F., O’Hagan, S., Day, P. J. & Kell, D. B. (2019). The role and robustness of the Gini coefficient as an unbiased tool for the selection of Gini genes for normalising expression profiling data. Sci Rep 9, 17960 (21pp). DOI: 10.1038/s41598-019-54288-7. Also bioRxiv, 18007.

van der Hoek SA, Darbani B, Zugaj K, Prabhala BK, Biron MB, Randelovic M, Medina JB, Kell DB, Borodina I (2019) Engineering the yeast Saccharomyces cerevisiae for the production of L-(+)-ergothioneine. Front Bioeng Biotechnol 7, 262.  doi: 10.3389/fbioe.2019.00262 Also bioRxiv 667592v667591.

de Villiers S, Bester J, Kell DB, Pretorius E: Erythrocyte health and the possible role of amyloidogenic blood clotting in the evolving haemodynamics of female migraine-with-aura pathophysiology: Results from a pilot study. Cephalalgia 2019; 39:150-151.

Scioscia M, Dekker GA, Chaouat G, Dawonauth L, Dechend R, Goldman-Wohl D, Gumilar E, Karumanchi SA, Kell DB, Rademacher TW, Robertson S, Saito S, Scherjon S, Staff AC, Vatish M, Robillard P-Y: A top priority in pre-eclampsia research: development of a reliable and inexpensive urinary screening test. Lancet Global Health 2019; 7:e1312-e1313. DOI: 10.1016/S2214-109X(19)30319-5.

Adams B, Nunes JM, Page MJ, Roberts T, Carr J, Nell TA, Kell DB, Pretorius E (2019) Parkinson’s disease: a systemic inflammatory disease accompanied by bacterial inflammagens. Front Aging Neurosci 11, 210. Preprint: bioRxiv 2019:646307v646301. DOI: 10.3389/fnagi.2019.00210.

Jindal S, Yang L, Day PJ, Kell DB (2019): Involvement of multiple influx and efflux transporters in the accumulation of cationic fluorescent dyes by Escherichia coli.  BMC Microbiol 19, 195 (16pp).   DOI 10.1186/s12866-019-1561-0. Preprint at  bioRxiv 603688v603681.

O’Hagan S, Kell DB (2019)  Generation of a small library of natural products designed to cover chemical space inexpensively. Pharm Front 1:e190005 (15pp). DOI:10.20900/pf20190005.

Zhang S, Sakuma M, Deora GS, Levy CW, Klausing A, Breda C, Read KD, Edlin CD, Ross BP, Wright Muelas M, Day PJ, O’Hagan S, Kell DB, Schwarcz R, Leys D, Heyes DJ, Giorgini F, Scrutton NS (2019). A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites. Commun Biol 2:271 (10pp). DOI: 10.1038/s42003-019-0520-5.

Currin A, Kwok J, Sadler JC, Bell EL, Swainston N, Ababi M, Day P, Turner NJ, Kell DB (2019). GeneORator: an effective strategy for navigating protein sequence space more efficiently through Boolean OR-type DNA libraries. ACS Synth Biol 8, 1371-1378. DOI: 10.1021/acssynbio.9b00063. Pubmed 31132850.

Kell DB: Control of metabolite efflux in microbial cell factories: current advances and future prospects. In El-Mansi EMT, Nielsen J, Mousdale D, Allman T, Carlson R (eds.): Fermentation microbiology and biotechnology, 4th ed. Boca Raton: CRC Press, 2019:117-138. (Preprint:  10.17605/OSF.IO/XG9JH).

Page MJ, Thomson GJA, Nunes JM, Engelbrecht A-M, Nell T, de Villiers WJS, de Beer MC, Engelbrecht L, Kell DB, Pretorius E (2019): Serum amyloid A binds to fibrin(ogen), promoting fibrin amyloid formation. Sci Rep 9, 3102. DOI: 10.1038/s41598-019-39056-x.

Jindal S, Thampy H, Day PJ, Kell DB (2019): Very rapid flow cytometric assessment of antimicrobial susceptibility during the apparent lag phase of bacterial (re)growth. Microbiology 165, 439–445. bioRxiv preprint. Pubmed 30741628, doi: 10.1099/mic.0.000777. Link to 2.5-minute scientific animation.

Visser MJE, Kell DB, Pretorius E (2019): Bacterial dysbiosis and translocation in psoriasis vulgaris. Front Cell Infect Microbiol 7, 9. DOI: doi: 10.3389/fcimb.2019.00007.

Pretorius L, Kell DB, Pretorius E. (2018). Iron dysregulation and dormant microbes as causative agents for impaired blood rheology and pathological clotting in Alzheimer’s type dementia. Frontiers in Neurosci 12, 851. DOI: 10.3389/fnins.2018.00851

de Waal GM, Engelbrecht L, Davis T, de Villiers WJS, Kell DB, Pretorius E (2018) Correlative Light-Electron Microscopy detects lipopolysaccharide and its association with fibrin fibres in Parkinson’s Disease, Alzheimer’s Disease and Type 2 Diabetes Mellitus. Sci. Rep. 8, 16798. DOI: 10.1038/s41598-018-35009-y.

Pretorius E, Bester J, Page MJ, Kell DB (2018): The potential of LPS-binding protein to reverse amyloid formation in plasma fibrin of individuals with Alzheimer-type dementia. Frontiers Aging Neurosci 10, 257. DOI: 10.3389/fnagi.2018.00257

Sadler JC, Green L, Swainston N, Kell DB, Currin A (2018) Fast and Flexible Synthesis of Combinatorial Libraries for Directed Evolution. Methods in Enzymology 608, 59-79. DOI 10.1016/bs.mie.2018.04.006.

Sadler JC, Currin A, Kell DB (2018) Ultra-high throughput functional enrichment of large monoamine oxidase (MAO-N) libraries by fluorescence activated cell sorting. Analyst 143, 4747-4755. PMID: 30199078. DOI: 10.1039/c8an00851

Carbonell P, Jervis AJ, Robinson CJ, Yan C, Dunstan M, Swainston N, Vinaixa M, Hollywood KA, Currin A, Rattray NJW, Taylor S, Spiess R, Sung R, Williams AR, Fellows D, Stanford NJ, Mulherin P, Feuvre RL, Barran P, Goodacre R, Turner NJ, Goble C, Chen GG, Kell DB, Micklefield J, Breitling R, Takano E, Faulon J-L, Scrutton NS: An automated Design-Build-Test-Learn pipeline for enhanced microbial production of fine chemicals. Commun Biol 2018; 1:66. DOI 10.1038/s42003-018-0076-9.

Darbani B, Kell DB, Borodina I (2018) Energetic Evolution of Cellular Transportomes. BMC Genomics 19, 418. PMID 29848286. DOI 10.1186/s12864-018-4816-5

Kell DB, Pretorius E (2018) To what extent are the terminal stages of sepsis, septic shock, SIRS, and multiple organ dysfunction syndrome actually driven by a toxic prion/amyloid form of fibrin? Semin Thromb Hemost 44, 224-238. PMID 28778104. DOI: 10.1055/s-0037-1604108. Prize for most viewed Open Access paper in the journal that year.

Kell DB, Welch GR: Belief: the baggage behind our being. 2018. Open Access Monograph. OSF preprints pnxcs. https://osf.io/pnxcs/. DOI: 10.17605/OSF.IO/PNXCS.

Kell DB: Control of metabolite efflux in microbial cell factories: current advances and future prospects. 2018. OSF preprints xg9jh. DOI: 10.17605/OSF.IO/XG9JH

Kell DB, Pretorius E (2018) No effects without causes. The Iron Dysregulation and Dormant Microbes hypothesis for chronic, inflammatory diseases: evidence and consequences. Biol Rev 93, 1518-1557. PMID 29575574. doi: 10.1111/brv.12407.  A closely related talk from this time is here.

Swainston, N, Dunstan M, Jervis AJ, Robinson CJ, Carbonell P, Williams AR, Breitling R, Faulon J-L, Scrutton NS, Kell DB (2018) PartsGenie: an integrated tool for optimising and sharing synthetic biology parts. Bioinformatics 34, 2327-2329. PMID 29949952. DOI: 10.1093/bioinformatics/bty105

Carbonell P, Wong J, Swainston N, Takano E, Turner N, Scrutton N, Kell DB, Breitling R, Faulon J-L (2018) Selenzyme: Enzyme selection tool for pathway design. Bioinformatics 34, 2153-2154. PMID 29425325. DOI: 10.1093/bioinformatics/bty065.

Currin A, Dunstan MS, Johannissen LO, Hollywood KA, Vinaixa M, Jervis AJ, Swainston N, Rattray NJW, Gardiner JM, Kell DB, Takano E, Toogood HS, Scrutton NS (2018) Engineering the ‘missing link’ in biosynthetic (–)-menthol production: bacterial isopulegone isomerase. ACS Catal 8, 2012-2020. DOI: 10.1021/acscatal.7b04115

Pretorius E, Page MJ, Mbotwe S, Kell DB (2018) Lipopolysaccharide-binding protein (LBP) can reverse the amyloid state of fibrin seen or induced in Parkinson’s disease. PlosOne 13, e0192121. DOI: 10.1371/journal.pone.0192121

Pretorius E, Page MJ, Hendricks L, Nkosi NB, Benson SR, Kell DB (2018) Both lipopolysaccharide and lipoteichoic acids potently induce anomalous fibrin amyloid formation: assessment with novel Amytracker™ stains. J R Soc Interface 20170941. Pubmed. DOI: 10.1098/rsif.2017.0941

O’Hagan S, Wright Muelas M, Day PJ, Lundberg E, Kell DB (2018) GeneGini: assessment via the Gini coefficient of reference ‘‘housekeeping’’ genes and diverse human transporter expression profiles. Cell Syst 6, 230-244. PMID 29428416. DOI https://10.1016/j.cels.2018.01.003

Kerley RN, McCarthy C, Kell DB, Kenny LC (2018) The potential therapeutic effects of ergothioneine in pre-eclampsia. Free Radic Biol Med 117, 145-157. PMID  29284116. https://doi.org/10.1016/j.freeradbiomed.2017.12.030.

O’Hagan, S. & Kell, D.B. (2018). Analysing and navigating natural products space for generating small, diverse, but representative chemical libraries. Biotechnol J, 1700503. PMID 29168302.   doi:10.1002/biot.201700503

Kenny, L. C. & Kell, DB (2018) Immunological tolerance, pregnancy and pre-eclampsia: the roles of semen microbes and the father. Front Med Obs Gynecol 4, 239.  DOI: 10.3389/fmed.2017.00239/full. PMID 29354635. Preprint at BioRxiv 198796 DOI: https://doi.org/10.1101/198796

Darbani B, Kell DB, Borodina I (2017). Energetic evolution of cellular transportomes. bioRxiv 218396. DOI 10.1101/218396

Pretorius, E., Page, M.J., Engelbrecht, L., Ellis, G.C., and Kell, D.B. (2017). Substantial fibrin amyloidogenesis in type 2 diabetes assessed using amyloid-selective fluorescent stains. Cardiovasc Diabetol 16, 141. PMID 29096623. doi: https://doi.org/10.1186/s12933-017-0624-5.

Pretorius E, Mbotwe S, Kell DB (2017) Lipopolysaccharide-binding protein (LBP) reverses the amyloid state of fibrin seen in plasma of type 2 diabetics with cardiovascular comorbidities. Sci Rep 7, 9680  doi:10.1038/s41598-017-09860-4

Glymenaki M, Barnes A, O’ Hagan S, Warhurst G, McBain AJ, Wilson ID, Kell DB, Else KJ, Cruickshank SM (2017). Stability in metabolic phenotypes and inferred metagenome profiles before the onset of colitis-induced inflammation. Sci Rep 7, 8836. DOI:10.1038/s41598-017-08732-1

Swainston N, Batista-Navarro R, Carbonell P, Dobson PD, Vinaixa M, Ananiadou S, Faulon J-L, Mendes P, Kell DB, Breitling R (2017) biochem4j: integrated and extensible biochemical knowledge through graph databases. PLoSOne,  12, e0179130. Pubmed 28708831. doi: https://doi.org/10.1371/journal.pone.0179130

O’Hagan S, Wright Muelas M, Day PJ, Lundberg E, Kell DB (2017) Novel ‘housekeeping’ genes and an unusually heterogeneous distribution of transporter expression profiles in human tissues and cell lines, assessed using the Gini coefficient. bioRxiv 2017:155697. doi: https://doi.org/10.1101/155697

O’Hagan S, Kell DB (2017) Consensus rank orderings of molecular fingerprints illustrate the ‘most genuine’ similarities between marketed drugs and small endogenous human metabolites, but highlight exogenous natural products as the most important ‘natural’ drug transporter substrates. ADMET & DMPK 5, 85-125. Pubmed. doi: 10.5599/admet.5.2.376

Pretorius E, Page MJ, Henricks L, Nkosi NB, Benson SR & Kell DB (2017) Both lipopolysaccharide and lipoteichoic acids potently induce anomalous fibrin amyloid formation: assessment with novel Amytracker™ stains. BioRxiv 143867. DOI: https://doi.org/10.1101/143867

Esteve C, Jones EA, Kell DB, Boutin H, McDonnell LA (2017) Mass spectral imaging shows major derangements in neurogranin and in purine metabolism in the triple-knockout 3xTg Alzheimer-like mouse model. Biochim Biophys Acta, 1865, 747-754. Pubmed 28411106.  DOI: https://doi.org/10.1016/j.bbapap.2017.04.002

Goodacre R, Kell DB (2017): Commentary on “Goodacre R, Timmins ÉM, Rooney PJ, Rowland JJ, Kell DB: Rapid identification of Streptococcus and Enterococcus species using diffuse reflectance-absorbance Fourier transform infrared spectroscopy and artificial neural networks. FEMS Microbiol Lett 1996; 140:233-239”, the most cited paper in the Journal for that year. FEMS Microbiol Lett, 364, fnx018. Pubmed 28130368. DOI doi: 10.1093/femsle/fnx018

Kell, DB (2017) Evolutionary algorithms and synthetic biology for directed evolution: Commentary on “On the mapping of genotype to phenotype in evolutionary algorithms”, by Peter A Whigham, Grant Dick & James Maclaurin. Genetic Progr Evolvable Mach 18, 373-378. DOI 10.1007/s10710-017-9292-1.

Swainston N, Currin A, Green L, Breitling R, Day PJ, Kell DB (2017) CodonGenie: optimised ambiguous codon design tools.  PeerJ Comp Sci 3, e120. DOI: https://doi.org/10.7717/peerj-cs.120.

Grixti J, O’Hagan S, Day PJ, Kell DB (2017): Enhancing drug efficacy and therapeutic index through cheminformatics-based selection of small molecule binary weapons that improve transporter-mediated targeting: a cytotoxicity system based on gemcitabine. Front Pharmacol 8, 155. DOI: 10.3389/fphar.2017.00155

O’Hagan S, Kell DB (2017) Analysis of drug-endogenous human metabolite similarities in terms of their maximum common substructures. J Cheminform 9, 18. DOI: 10.1186/s13321-017-0198-y.

Currin A, Korovin K, Ababi M, Roper K, Kell DB, Day PJ, King RD (2017) Computing exponentially faster: Implementing a nondeterministic universal Turing machine using DNA. J R Soc Interface 14:20160990. PMID. DOI 10.1098/rsif.2016.0990

O’Hagan S, Kell DB (2017) Consensus rank orderings of molecular fingerprints illustrate the ‘most genuine’ similarities between marketed drugs and small endogenous human metabolites, but highlight exogenous natural products as the most important ‘natural’ drug transporter substrates. bioRxiv version. bioRxiv 2017:110437.

Kell, D. B. & Pretorius, E. (2017). Proteins behaving badly. Substoichiometric molecular control and amplification of the initiation and nature of amyloid fibril formation: lessons from and for blood clotting. Progr Biophys Mol Biol 123, 16-41. PMID 27554450. DOI: 10.1016/j.pbiomolbio.2016.08.006.

Pretorius, E., Akeredolu, O.-O., Soma, P. & Kell, D.B. (2017). Major involvement of bacterial components in rheumatoid arthritis and its accompanying oxidative stress, systemic inflammation and hypercoagulability. Exp Biol Med. 242, 355-373. PMID 27889698. DOI: 10.1177/1535370216681549.

Currin A, Swainston N, Day PJ, Kell DB (2017) SpeedyGenes: exploiting an improved gene synthesis method for the efficient production of error-corrected, synthetic protein libraries for directed evolution. Meth Mol Biol 1472:63-78. PMID 27671932. DOI 10.1007/978-1-4939-6343-0_5.

Pretorius, E., Mbotwe, S., Bester, J., Robinson, C. and Kell, D.B., 2016. Acute induction of anomalous and amyloidogenic blood clotting by molecular amplification of highly substoichiometric levels of bacterial lipopolysaccharide. J R Soc Interface. 20160539. DOI: 10.1098/rsif.2016.0539

Kell, D.B. & Oliver, S.G. (2016). The metabolome 18 years on: a concept comes of age. Metabolomics, 12, 148. pmid. DOI: 10.1007/s11306-016-1108-4. Made the cover.

O’Hagan, S. & Kell, D. B. (2016). MetMaxStruct: a Tversky-similarity-based strategy for analysing the (sub)structural similarities of drugs and endogenous metabolites. Front Pharmacol 7, 266. DOI: 10.3389/fphar.2016.00266

Swainston N, Smallbone K, Hefzi H, Dobson PD, Brewer J, Hanscho M, Zielinski DC, Ang KS, Gardiner NJ, Gutierrez JM, Kyriakopoulos S, Lakshmanan M, Li S, Liu JK, Martínez VS, Orellana CA, Quek L-E, Thomas A, Zanghellini J, Borth N, Lee D-Y, Nielsen LK, Kell DB, Lewis NE, Mendes P (2016): Recon 2.2: from reconstruction to model of human metabolism. Metabolomics 12, 109. DOI: 10.1007/s11306-016-1051-4. PMID 27358602. Link to SBML Model.

Currin A, Korovin K, Ababi M, Roper K, Kell DB, Day PJ, King RD (2016) Computing exponentially faster: Implementing a nondeterministic universal Turing machine using DNA. arXiv. 2016:1607.08078v1. pdf.

Le Feuvre RA, Carbonell P, Currin A, Dunstan M, Fellows D, Jervis AJ, Rattray NJW, Robinson CJ, Swainston N, Vinaixa M, Williams A, Yan C, Barran P, Breitling R, Chen GG, Faulon J-L, Goble C, Goodacre R, Kell DB, Micklefield J, Scrutton NS, Shapira P, Takano E, Turner NJ: SYNBIOCHEM Synthetic Biology Research Centre, Manchester: A UK foundry for fine and speciality chemicals production. Synth Syst Biol 2016; 1:271-275.

Carbonell P, Currin A, Dunstan M, Fellows D, Jervis A, Rattray NJW, Robinson CJ, Swainston N, Vinaixa M, Williams A, Yan C, Barran P, Breitling R, Chen GG, Faulon JL, Goble C, Goodacre R, Kell DB, Feuvre RL, Micklefield J, Scrutton NS, Shapira P, Takano E, Turner NJ (2016): SYNBIOCHEM – a SynBio foundry for the biosynthesis and sustainable production of fine and speciality chemicals. Biochem Soc Trans 44:675-677. SYNBIOCHEM paper. PMID 27284023. http://dx.doi.org/10.1042/BST20160009.

Kell DB, Pretorius E (2016) To what extent are the terminal stages of sepsis, septic shock, SIRS, and multiple organ dysfunction syndrome actually driven by a toxic prion/amyloid form of fibrin? bioRxiv preprint. bioRxiv 2016:057851. pdf version. DOI: http://dx.doi.org/10.1101/057851.

Kell DB, Kenny LC (2016). A dormant microbial component in the development of pre-eclampsia. BioRxiv preprint. bioRxiv 2016:057356. pdf version. DOI: http://dx.doi.org/10.110/057356

Pretorius E, Bester J, Kell DB (2016). A bacterial component to Alzheimer-type dementia seen via a systems biology approach that links iron dysregulation and inflammagen shedding to disease. J Alzheimers Dis 53, 1237-1256. Abstract. pdf. DOI: DOI 10.3233/JAD-160318. PMID 27340854.

Kell DB, Pretorius E (2016) Substoichiometric molecular control and amplification of the initiation and nature of amyloid fibril formation: lessons from and for blood clotting. bioRxiv preprint. biorRxiv 2016:054734. http://dx.doi.org/10.1101/054734

Pretorius E, Mbotwe S, Bester J, Robinson C, Kell DB (2016): Acute induction of anomalous blood clotting by highly substoichiometric levels of bacterial lipopolysaccharide (LPS). bioRxiv 2016-053538. DOI: http://dx.doi.org/10.1101/053538

Itzhaki RF, Lathe R, Balin BJ, Ball MJ, Braak H, Bearer EL, Bullido MJ, Carter C, Clerici M, Cosby SL, Del Tredici K, Field H, Fulop T, Grassi C, Griffin WST, Haas J, Hudson AP, Kamer A, Kell DB, Licastro F, Letenneur L, Lövheim H, Mancuso R, Miklossy J, Otth C, Palamara AT, Perry G, Preston C, Pretorius E, Strandberg T, Tabet N, Taylor-Robinson SD & Whittum-Hudson JA (2016) Microbes and Alzheimer’s Disease. J Alzheimers Dis 51:979-984. get pdf. DOI:10.3233/JAD-160152. PMID 26967229.

Mendes, P., Oliver, S.G. & Kell, D.B. (2016) Response to ‘the need for speed’, by Matsson et al. pdf. DOI: http://dx.doi.org/10.1016/j.tips.2016.02.004. PMID 26924017.

Kell, D.B. (2016). How drugs pass through biological cell membranes – a paradigm shift in our understanding? Beilstein Magazine, 2016, 2, No. 5. pdf version doi:10.3762/bmag.5. SYNBIOCHEM paper.

Kell, D.B. (2016). Implications of endogenous roles of transporters for drug discovery: hitchhiking and metabolite-likeness. Nat Rev Drug Disc 15, 143-144. doi:10.1038/nrd.2015.44. SYNBIOCHEM paper. PMID 26837595.

Tapinos, A., Constantinides, B., Kell, D.B., and Robertson, D.L. (2016). Alignment by Numbers: Sequence Assembly Using Compressed Numerical Representations. bioRkiv. doi:10.1101/011940

Kell DB, Pretorius E (2015) On the translocation of bacteria and their lipopolysaccharides between blood and peripheral locations in chronic, inflammatory diseases: the central roles of LPS and LPS-induced cell death. Integr Biol 7, 1339-1377. DOI: 10.1039/c5ib00158g. SYNBIOCHEM paper. Accepted ms as pdf here. PMID 26345428.

O’Hagan S, Kell DB. (2015). The apparent permeabilities of Caco-2 cells to marketed drugs: magnitude, and independence from both biophysical properties and endogenite similarities. PeerJ 3, e1405. DOI: 10.7717/peerj.1405. SYNBIOCHEM paper. pdf version. Preprint here. PMID 26618081.

Mendes P, Oliver SG, Kell DB (2015) Fitting transporter activities to cellular drug concentrations and fluxes: why the bumblebee can fly. Trends Pharmacol Sci 36 (11), 710-723. DOI:10.1016/j.tips.2015.07.006. SYNBIOCHEM paper. PMID 26538313.

Bester J, Soma P, Kell DB, Pretorius E (2015) Viscoelastic and ultrastructural characteristics of whole blood and plasma in Alzheimer-type dementia, and the possible role of bacterial lipopolysaccharides (LPS). Oncotarget Gerontology 6, 35284-35303. early pdf here. DOI: 10.18632/oncotarget.6074. PMID 26462180.

Kell DB, Pretorius E (2015) Interpreting raised serum ferritin levels. BMJ 2015, 351. DOI: 10.1136/bmj.h36922.

O’Hagan S, and Kell DB. (2015). Software review: The KNIME workflow environment and its applications in Genetic Programming and machine learning. Genetic Progr Evol Mach 16, 387-391. DOI: 10.1007/s10710-015-9247-3. SYNBIOCHEM paper.

Kell, DB, Potgieter, M & Pretorius, E (2015) Individuality, phenotypic differentiation, dormancy and ‘persistence’ in culturable bacterial systems: commonalities shared by environmental, laboratory, and clinical microbiology. F1000Research 4, 179. DOI: 10.12688/f1000research.6709.1 . SYNBIOCHEM paper.

Ananiadou S, Thompson P, Nawaz R, McNaught J, Kell DB (2015) Event-based text mining for biology and functional genomics. Brief Funct Genomics 14, 213-230. DOI: 10.1093/bfgp/elu015. Took 11 months from being online, hence PMID 24907365.

O’Hagan S, Kell DB (2015) Understanding the foundations of the structural similarities between marketed drugs and endogenous human metabolites. Front Pharmacol 6, 105. DOI 10.3389/fphar.2015.00105. SYNBIOCHEM paper. PMID 26029108

Potgieter M, Bester J, Kell DB, Pretorius E (2015). The dormant blood microbiome in chronic, inflammatory diseases. FEMS Microbiol Rev 39, 567-591. DOI: 10.1093/femsre/fuv013. PMID 25940667.

Pretorius E, Bester J, Vermeulen N, Alummoottil S, Soma P, Buys AV, Kell DB (2015). Poorly controlled type 2 diabetes is accompanied by significant morphological and ultrastructural changes in both erythrocytes and in thrombin-generated fibrin: implications for diagnostics. Cardiovasc Diabetol 13, 30. DOI:10.1186/s12933-015-0192-5. PMID 25848817.

Kell DB, Swainston N, Pir P, Oliver SG (2015). Membrane transporter engineering in industrial biotechnology and whole-cell biocatalysis. Trends Biotechnol 33, 237-246. Scholarly and fully referenced manuscript as submitted. DOI:10.1016/j.tibtech.2015.02.001. SYNBIOCHEM paper. PMID 25746161.

O’Hagan S, Swainston N, Handl J, Kell DB (2015) A ‘rule of 0.5’ for the metabolite-likeness of approved pharmaceutical drugs. Metabolomics 11 (2), 323-339; DOI 10.1007/s11306-11014-10733-z. Minor erratum on p 340. PMID 25750602.

Currin A, Swainston N, Day PJ, Kell DB (2015) Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently. Chem Soc Rev 44, 1172-1239. DOI: 10.1039/c1034cs00351a. SYNBIOCHEM paper. PMID 25503938.

Tapinos A, Constantinides B, Kell DB, Robertson DL (2015): Alignment by Numbers: Sequence Assembly Using Compressed Numerical Representations. bioRkiv 2015: http://biorxiv.org/content/early/2015/2001/2027/011940 (pdf).

Dunn WB, Lin W, Broadhurst D, Begley P, Brown M, Zelena E, Vaughan AA, Halsall A, Harding N, Knowles JD, Francis-McIntyre S, Tseng A, Ellis DI, O’Hagan S, Aarons G, Benjamin B, Chew-Graham S, Moseley C, Potter P, Winder CL, Potts C, Thornton P, McWhirter C, Zubair M, Burns A, Cruickshank JK, Jayson GC, Purandare N, Wu FW, Finn JD, Haselden JN, Nicholls AW, Wilson ID, Goodacre R, Kell DB (2015) Molecular phenotyping of a UK population: defining the human serum metabolome. Metabolomics 11, 9-26. DOI: 10.1007/s11306-014-0707-1. Made the cover. PMID 25598764.

Kell, D. B. (2015) What would be the observable consequences if phospholipid bilayer diffusion of drugs into cells is negligible? Trends Pharmacol Sci 36, 15-21. DOI: 10.1016/j.tips.2014.10.005. Recommended by F1000Prime. SYNBIOCHEM paper. PMID 25458537.

Kell, D. B. & Pretorius, E. (2015). The simultaneous occurrence of both hypercoagulability and hypofibrinolysis in blood and serum during systemic inflammation, and the roles of iron and fibrin(ogen). Integr Biol. 7, 24-52. DOI: 10.1039/c4ib00173g. Badged as a HOT paper. PMID 25335120.

Kell DB, Lurie-Luke E: The virtue of innovation: innovation through the lenses of biological evolution. J R Soc Interface 2015; 12:20141183. DOI: 10.1098/rsif.2014.1183. SYNBIOCHEM paper. PMID 25505138.

Kell, D. B. & Oliver, S. G. (2014). How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion. Front Pharmacol, 5, 231. PMID 25400580.

Anderson, S. G., Dunn, W. B., Banerjee, M., Brown, M., Broadhurst, D. I., Goodacre, R., Cooper, G. J. S., Kell, D. B. & Cruickshank, J. K. (2014). Evidence that multiple defects in lipid regulation occur before hyperglycemia during the prodrome of type-2 diabetes. PLoS One 9, e103217. PMID 25184286.

Currin A, Swainston N, Day PJ, Kell DB (2014) SpeedyGenes: a novel approach for the efficient production of error-corrected, synthetic gene libraries. Protein Eng Design Sel 27, 273-280. DOI 10.1093/protein/gzu029 Made the cover. PMID 25108914.

Swainston N, Currin A, Day PJ, Kell DB (2014) GeneGenie: optimised oligomer design for directed evolution. Nucleic Acids Res 12, W395-W400 doi: 10.1093/nar/gku336. PMID 24782527.

Kell DB (2014) Mental health: Drug search on risky path. Nature 508, 458.

Pretorius E, Kell DB (2014) Diagnostic morphology: biophysical indicators for iron-driven inflammatory diseases. Integrative Biol. 6, 486-510. DOI: 10.1039/c1034ib00025k. Among the most accessed articles of 2014 in this journal. PMID 24714688.

Kell DB, Pretorius E. (2014) Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells. Metallomics 6, 748-773. PMID 24549403.

Kell DB, Goodacre R (2014) Metabolomics and systems pharmacology: why and how to model the human metabolic network for drug discovery. Drug Disc Today 19, 171-182. PMID 23892182.

Pretorius E, Bester J, Vermeulen N, Lipinski B, Gericke GS, Kell DB (2014) Profound morphological changes in the erythrocytes and fibrin networks of patients with hemochromatosis or with hyperferritinemia, and their normalization by iron chelators and other agents. PLoS One 9, e85271. PMID 24416376.

Dikicioglu D, Oc S, Rash B, Dunn WB, Pir P, Kell DB, Kirdar B, Oliver SG (2014) Yeast cells with impaired drug resistance accumulate glycerol and glucose. Mol Biosyst 10: 93-102. PMID 24157722.

Bester J, Buys AV, Lipinski B, Kell DB, Pretorius E (2013) High ferritin levels have major effects on the morphology of erythrocytes in Alzheimer’s disease. Front Aging Neurosci, 5, 00088. PMID 24367334.

Büchel F, Rodriguez N, Swainston N, Wrzodek C, Czauderna T, Keller R, Mittag F, Schubert M, Glont M, Golebiewski M, van Iersel M, Keating S, Rall M, Wybrow M, Hermjakob H, Hucka M, Kell DB, Müller W, Mendes P, Zell A, Chaouiya C, Saez-Rodriguez J, Schreiber F, Laibe C, Dräger A, Novère NL (2013) Path2models: large-scale generation of computational models from biochemical pathway maps. BMC Syst Biol 7, 116. Link to OA journal page. PMID 24180668.

Kell, D.B. (2013) Finding novel pharmaceuticals in the systems biology era using multiple effective drug targets, phenotypic screening, and knowledge of transporters: where drug discovery went wrong and how to fix it. FEBS J. 280, 5957-5980. PMID 23552054.

Smallbone K, Messiha HL, Carroll KM, Winder CL, Malys N, Dunn WB, Murabito E, Swainston N, Dada JO, Khan F, Pir P, Simeonidis E, Spasić I, Wishart J, Weichart D, Hayes NW, Jameson D, Broomhead DS, Oliver SG, Gaskell SJ, McCarthy JEG, Paton NW, Westerhoff HV, Kell DB, Mendes P (2013) A model of yeast glycolysis based on a consistent kinetic characterisation of all its enzymes. FEBS Lett 587, 2832-2841. PMID 23831062.

Swainston, N., Mendes, P. & Kell, D.B. (2013) An analysis of a ‘community-driven’ reconstruction of the human metabolic network. Metabolomics 9, 757-764. PMID 23888127.

Miwa M, Ohta T, Rak R, Rowley A, Kell DB, Pyysalo S and Ananiadou S (2013) A method for integrating and ranking the evidence for biochemical pathways by mining reactions from text. Bioinformatics 29, i44-i52. PMID 23813008.

Funke, C., Schneider, S.A., Berg, D., and Kell, D.B., (2013) Genetics and iron in the systems biology of Parkinson’s disease and some related disorders, NeurochemInternat 62, 637–652. PMID 23220386.

Kell, D. B., Dobson, P. D., Bilsland, E. and Oliver, S. G. (2013). The promiscuous binding of pharmaceutical drugs and their transporter-mediated uptake into cells: what we (need to) know and how we can do so. Drug Discovery Today, 18, 218-239. PMID 23207804.

Thiele, I., Swainston, N., Fleming, R. M. T., Hoppe, et al. (2013). A community-driven global reconstruction of human metabolism. Nature Biotechnol., 31, 419-425. DOI:10.1038/nbt.2488. PMID 23455439.

Pretorius, E., Vermeulen, N., Bester, J., Lipinski, B., Kell, D.B. (2013): A novel method for assessing the role of iron and its functional chelation in fibrin fibril formation: the use of scanning electron microscopy. Toxicol Mech Methods 23, 352-359. DOI:10.3109/15376516.2012.762082. PMID 23278212.

Kell, D.B. (2012) Reviews turn facts into understanding. Nature 490, 37. PMID 23038456.

Dunn, W. B., Brown, M., Worton, S. A., Davies, K., Jones, R. L., Kell, D. B. & Heazell, A. E. P. (2012). The metabolome of human placental tissue: investigation of first trimester tissue and changes related to preeclampsia in late pregnancy. Metabolomics (2012) 8:579–597, doi:10.1007/s11306-011-0348-6

Lee, D., Smallbone, K., Dunn, W. B., Murabito, E., Winder, C. L., Kell, D. B., Mendes, P. & Swainston, N. (2012). Improving metabolic flux predictions using absolute gene expression data. BMC Systems Biology 6, 73. PMID 22713172.

Miwa, M., Thompson, P., McNaught, J., Kell, D.B. & Ananiadou, S. (2012) Extracting semantically enriched events from biomedical literature. BMC Bioinformatics 2012, 13:108. PMID 22621266.

Dikicioglu, D., Dunn, W. B., Kell, D. B., Kirdar, B. & Oliver, S. G. (2012). Short- and long-term dynamic responses of the metabolic network and gene expression in yeast to a transient change in the nutrient environment. Mol BioSyst 8, 1760-1774. PMID 22491778.

Kell D.B. (2012) Large-scale sequestration of carbon via plant roots in natural and agricultural ecosystems: why and how. Phil Trans R Soc 367, 1589-1597. PMID 22527402.

Davey, H. M., Cross, E. J. M., Davey, C. L., Gkargkas, K., Delneri, D., Hoyle, D. C., Oliver, S. G., Kell, D. B. & Griffith, G. W. (2012). Genome-wide analysis of longevity in nutrient-deprived Saccharomyces cerevisiae reveals the importance of recycling in maintaining cell viability. Env Microbiol 14, 1249-1260. PMID 22356628.

Wang, Y., Paszek, P., Horton, C. A., Yue H., White M. R. H., Kell D. B., Muldoon M. R. & Broomhead D. S. (2012). A systematic survey of the response of a model NF-κB signalling pathway to TNFα stimulation. J. Theoret. Biol., 297, 137-147. PMID 22202812.

Kell, D.B. (2012). Scientific discovery as a combinatorial optimisation problem: How best to navigate the landscape of possible experiments? BioEssays (online early view). PMID 22252984.

Pir, P., Gutteridge, A., Wu, J., Rash, B., Kell, D. B., Zhang, N. & Oliver, S. G. (2012). The genetic control of growth rate: a systems biology study in yeast. BMC Sys Bio 6:4. PMID 22244311.

Courtot, M., Juty, N., Knupfer, C., Waltemath, D., Zhukova, A., Drager, A., Dumontier, M., Finney, A., Golebiewski, M., Hastings, J., Hoops, S., Keating, S., Kell, D. B., Kerrien, S., Lawson, J., Lister, A., Lu, J., Machne, R., Mendes, P., Pocock, M., Rodriguez, N., Villeger, A., Wilkinson, D. J., Wimalaratne, S., Laibe, C., Hucka, M. and Le Novere, N. (2011). Controlled vocabularies and semantics in systems biology. Mol Syst Biol 7:543. PMID 22027554.

Small, B. G., McColl, B. W., Allmendinger, R., Pahle, J., López-Castejón, G., Rothwell, N. J., Knowles, J., Mendes, P., Brough, D., and Kell, D. B. (2011). Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing. Nature Chemical Biology 7, 902-908. DOI:10.1038/nchembio.689. PMID 22020553.

Lanthaler, K., Bilsland, E., Dobson, P. D., Moss, H. J., Pir, P., Kell, D. B., and Oliver, S. G. (2011). Genome-wide assessment of the carriers involved in the cellular uptake of drugs: a model system in yeast. BMC Biology 2011, 9:70. PMID 22023736.

Carroll, K. M., Simpson, D. M., Eyers, C. E., Knight, C. G., Brownridge, P., Dunn, W., Winder, C. L., Lanthaler, K., Pir, P., Malys, N., Kell, D.B., Oliver, S. G., Gaskell, S. J. & Beynon, R. J. (2011). Absolute quantification of the glycolytic pathway in yeast: deployment of a complete QconCAT approach.Mol Cell Proteomics 10, M111 007633. PMID 21931151.

Horgan, R. P., Broadhurst, D. I., Walsh, S. K., Dunn, W. B., Brown, M., Roberts, C., North, R. A., McCowan, L., Kell, D. B., Baker, P. N. & Kenny, L. C. (2011). Metabolic profiling uncovers a phenotypic signature of Small for Gestational Age in early pregnancy. J Proteome Res 10, 3660-3673. PMID 21671558.

Kell DB. Carbon dioxide – an age-old problem. FST Journal 2011; 20:22-23.

Kell DB. (2011). Breeding crop plants with deep roots: their role in sustainable carbon, nutrient and water sequestration. Annals of Botany 108, 407-418. DOI:10.1093/aob/mcr175. PMID 21813565.

Kell DB, Dobson PD, Oliver SG (2011). Pharmaceutical drug transport: the issues and the implications that it is essentially carrier-mediated only. Drug Discovery Today. (2011) 16:15-16 704-714. doi:10.1016/j.drudis.2011.05.010. PMID 21624498.

Dunn WB, Broadhurst D, Begley P, Zelena E, Francis-McIntyre S, Anderson N, Brown N, Knowles J, Halsall A, Haselden JN, Nicholls A, Wilson ID, Kell DB, Goodacre R and The Husermet consortium (2011). Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry. Nature Protocols 6:1060-1083. PMID 21720319.

Flavell, R., de Brito Cruz, C. H., Christie, M., Allen, J., Keller, M., Gilna, P. & Kell, D. B. (2011). Moving forward with biofuels. Nature Outlook Biofuels 474, S44-S48.

Brown, M., Wedge, D., Goodacre, R., Kell, D. B., Baker, P. N., Kenny, L. C., Mamas, M. A., Neyses, L. & Dunn, W. B. (2011). Automated workflows for accurate mass-based putative metabolite identification in LC/MS-derived metabolomic datasets. Bioinformatics 27, 1108-1112. PMID 21325300.

Nobata, C., Dobson, P., Iqbal, S. A., Mendes, P., Tsujii, J. i., Kell, D. B. & Ananiadou, S. (2011). Mining metabolites: extracting the yeast metabolome from the literature. Metabolomics 7, 94-101. PMID 21687783.

Patel, Y., Heyward, C. A., White, M. R. H. & Kell, D. B. (2011). Predicting the points of interaction of small molecules in the NF-kappaB pathway. BMC Systems Biology 5, 32. PMID 21342508.

Kell DB: Understanding the languages of cells. Network modelling in metabolic systems biology and biotechnology: why, how and whither. The Biochemist 2011; 33:4-7.

Wang, Y., Paszek, P., Horton, C. A., Kell, D. B., White, M. R. H., Broomhead, D. S. and Muldoon, M. R. (2011), Interactions among oscillatory pathways in NF- kappa B signalling., BMC Systems Biology 2011, 5:23. DOI: 10.1186/1752-0509-5-23. (online version). PMID 21291535.

Kell D.B.: Metabolites do social networking. Nat Chem Biol 2011; 7:7-8. PMID 21164512.

Kell, D. B. (2010). Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examples. Arch Toxicol 577, 825-889. (Online version here.) PMID 20967426.

Dobson, P. D., Smallbone, K., Jameson, D., Simeonidis, E., Lanthaler, K., Pir, P., Lu, C., Swainston, N., Dunn, W. B., Fisher, P., Hull, D., Brown, M., Oshota, O., Stanford, N. J., Kell, D. B., King, R. D., Oliver, S. G., Stevens, R. D. & Mendes, P. (2010). Further developments towards a genome-scale metabolic model of yeast. BMC Systems Biology 4, 145. PMID 21029416.

Horgan RP, Broadhurst DI, Dunn WB, Brown MC, Heazell AE, Kell DB, Baker PN, Kenny LC: Changes in the metabolic footprint of placental villous explants cultured in different oxygen tensions from placentas of Small for Gestational Age and normal pregnancies. Placenta 2010; 31:893-901. PMID 20708797.

Rowe W, Wedge DC, Platt M, Kell DB, Knowles J: Predictive models for population performance on real biological fitness landscapes. Bioinformatics 2010; 26:45-52. PMID 20639542.

Attwood TK, Kell DB, McDermott P, Marsh J, Pettifer S, Thorne D: Utopia Documents: linking scholarly literature with research data. Bioinformatics 2010; 26:i568-574. PMID 20823323.

Swainston N, Golebiewski M, Messiha H, Malys N, Kania R, Kengne S, Krebs O, Mir S, Sauer-Danzwith H, Smallbone K, Weidemann A, Wittig U, Kell D, Mendes P, Müller W, Paton N, Rojas I: Enzyme kinetics informatics: from instrument to browser. FEBS J 2010; 277:3769–3779. PMID 20738395.

Kenny LC, Broadhurst DI, Dunn W, Brown M, Francis-McIntyre S, North RA, McGowan L, Roberts C, Cooper GJS, Kell DB, Philip N Baker on behalf of the SCOPE consortium: Robust early pregnancy prediction of later preeclampsia using metabolomic biomarkers. Hypertension 2010; 56:741-749. PMID 20837882.

Kell, D. B. (2010). Systems microbiology. Microbiol Today 37, 14-15.

Rowe, W., Platt, M., Wedge, D. C., Day, P. J. R., Kell, D. B. & Knowles, J. D. (2010). Convergent evolution to an aptamer observed in small populations on DNA microarrays. Phys Biol 7, 036007. PMID 20811084.

Ananiadou, S., Pyysalo, S., Tsujii, J. i. & Kell, D. B. (2010). Event extraction for systems biology by text mining the literature. Trends Biotechnol 2010; 28:381-390. PMID 20570001.

Villéger, A. C., Pettifer, S. R. & Kell, D. B. (2010). Arcadia: a visualization tool for metabolic pathways. Bioinformatics 20, 1470-1. PMID 20453003.

Rowe, W., Platt, M., Wedge, D., Day, P. J., Kell, D. B. & Knowles, J. (2010). Analysis of a complete DNA-protein affinity landscape. J R Soc Interface 7, 397-408. (Supplementary data.) PMID 19625306.

Attwood, T. K.,Kell, D. B., McDermott, P., Marsh, J., Pettifer, S. R. & Thorne, D. (2009).Calling International Rescue: knowledge lost in literature and data landslide! Biochem J. 424, 317-333. See also: Get Utopia Software. PMID 19929850.

Dunn, W. B., Brown, M., Worton , S. A., Crocker, I. P., Broadhurst, D., Horgan, R., Kenny, L. C., Baker, P. N., Kell, D. B. & Heazell, A. E. P. (2009). Changes in the metabolic footprint of placental explant-conditioned culture medium identifies metabolic disturbances related to hypoxia and pre-eclampsia. Placenta 37, 974-980. PMID 19775752.

Kell DB: The importance of mathematics in systems biology. Mathematics Today 2009; August issue:167-172.

Williamson, T., Schwartz, J.-M., Kell, D. B. & Stateva, L. (2009). Deterministic mathematical models of the cAMP pathway in Saccharomyces cerevisiae. BMC Systems Biology 3, 70. PMID 19607691.

Handley, C. M., Hawe, G. I., Kell, D. B. & Popelier, P. L. A. (2009). Optimal construction of a fast and accurate polarisable water potential based on multipole moments trained by machine learning. Phys Chem Chem Phys 11, 6365-6376. PMID 19809668.

Begley, P., Francis-McIntyre, S., Dunn, W. B., Broadhurst, D. I., Halsall, A., Tseng, A., Knowles, J., HUSERMET consortium, Goodacre, R. & Kell, D. B. (2009). Development and performance of a gas chromatography-time-of-flight mass spectrometry analysis for large-scale non-targeted metabolomic studies of human serum. Anal Chem 81, 7038-7046. PMID 19606840.

Le Novère, N., Hucka, M., Mi, H., Moodie, S., Schreiber, F., Sorokin, A., Demir, E., Wegner, K., Aladjem, M., Wimalaratne, S. M., Bergman, F. T., Gauges, R., Ghazal, P., Hideya, K., Li, L., Matsuoka, Y., Villéger, A., Boyd, S. E., Calzone, L., Courtot, M., Dogrusoz, U., Freeman, T., Funahashi, A., Ghosh, S., Jouraku, A., Kim, S., Kolpakov, F., Luna, A., Sahle, S., Schmidt, E., Watterson, S., Wu, G., Goryanin, I., Kell, D. B., Sander, C., Sauro, H., Snoep, J. L., Kohn, K. & Kitano, H. (2009). The systems biology graphical notation. Nat Biotechnol 27, 735-741. Supplementary information. PMID 19668183.

Kell, D. B. (2009). Journal Club: A systems biologist ponders how disparate ideas can sometimes come together beautifully. Nature 460, 669.

Kell, D. B. (2009). Correspondence – Dormant microbes: time to revive some old ideas, Nature 458, 831.

Jameson, D., Turner, D. A., Ankers, J., Kennedy, S., Ryan, S., Swainston, N., Griffiths, T., Spiller, D. G., Oliver, S. G., White, M. R. H., Kell, D. B. & Paton, N. W. (2009). Information management for high content live cell imaging. BMC Bioinformatics 10, 226. PMID 19622144.

Platt, M., Rowe, W., Wedge, D. C., Kell, D. B., Knowles, J. & Day, P. J. R. (2009). Aptamer evolution for array-based diagnostics. Anal Biochem, 390, 203-205. PMID 19374883.

Brown, M., Dunn, W. B., Dobson, P., Patel, Y., Winder, C. L., Francis-McIntyre, S., Begley, P., Carroll, K., Broadhurst, D., Tseng, A., Swainston, N., Spasic, I., Goodacre, R. & Kell, D. B. (2009). Mass spectrometry tools and metabolite-specific databases for molecular identification in metabolomics. Analyst 134, 1322-1332. PMID 19562197.

Pettifer, S. R., Thorne, D., McDermott, P., Marsh, J., Villéger, A., Kell, D. B. & Attwood, T. K. (2009). Visualising biological data: a semantic approach to tool and database integration. BMC Bioinformatics 10, S19. PMID 19534744.

Spasic, I., Simeonidis, E., Messiha, H. L., Paton, N. W. & Kell, D. B. (2009). KiPar, a tool for systematic information retrieval regarding parameters for kinetic modelling of yeast metabolic pathways. Bioinformatics 25, 1404-1411. PMID 19336445.

Kell, D. B. (2009). Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases. BMC Medical Genomics 2, 2 – doi:10.1186/1755-8794-2-2 One of our most accessed papers! See BMC Medical Genomics: Most accessed articles of the past year, and of all time. PMID 19133145.

Ashall, L., Horton, C. A., Nelson, D. E., Paszek, P., Ryan, S., Sillitoe, K., Harper, C. V., Spiller, D. G., Unitt, J. F., Broomhead, D. S., Kell, D. B., Rand, D., Sée, V. & White, M. R. H. (2009). Pulsatile stimulation determines timing and specificity of NF-κ-B-dependent transcription. Science 324, 242-246. Supplementary Information. PMID 19359585.

Das, A., Dost, R., Richardson, T. H., Grell, M., Wedge, D. C., Kell, D. B., Morrison, J. J. & Turner, M. L. (2009). Low cost, portable,fast multiparameter data acquisition system for organic transistor odour sensors. Sens. Act. B 137, 586-591

Kell, D. B. & Dobson, P. D. (2009). The cellular uptake of pharmaceutical drugs is mainly carrier-mediated and is thus an issue not so much of biophysics but of systems biology. In Systems Chemistry, pp. 149-168. Beilstein Institute, Frankfurt

Dobson, P., Lanthaler, K., Oliver, S. G. & Kell, D. B. (2009). Implications of the dominant role of cellular transporters in drug uptake. Curr Top Med Chem 9, 163-184. PMID 19200003.

Platt, M., Rowe, W., Knowles, J., Day, P. J. & Kell, D. B. (2009). Analysis of aptamer sequence-activity relationships. Integr Biol 1, 116-122. DOI: 10.1039/b814892a. PMID 20023798.

Zelena, E., Dunn, W., Broadhurst, D., Francis-McIntyre, S., Carroll, K., Begley, P., O’Hagan, S., Knowles, J. D., Halsall, A., HUSERMET Consortium, Wilson, I. & Kell, D.B. (2009). Development of a robust and repeatable UPLC-MS method for the long-term metabolomic study of human serum. Anal Chem 81, 1357-1364. PMID 19170513.

Wedge, D., Rowe, W., Kell, D. B. & Knowles, J. (2009). In silico modelling of directed evolution: implications for experimental design and stepwise evolution. J Theor Biol, 2009, 131-141. PMID 19073195.

Knight, C.G., Platt, M., Rowe, W., Wedge, D.C., Khan, F., Day, P.J.R., McShea, A., Knowles, J. and Kell, D.B. (2009). Array-based evolution of DNA aptamers allows modelling of an explicit sequence-fitness landscape. Nucleic Acids Research, 2009, Vol. 37, No. 1 e6 (Supplementary info: 1, 2, 3 & 4 Data: Training Data; Test Sequence Data; Readme.txt.) PMID 19029139.

Dobson, P. D., Patel, Y. & Kell, D. B. (2009). “Metabolite-likeness” as a criterion in the design and selection of pharmaceutical drug libraries. Drug Disc Today, 14, 31-40. PMID 19049901.

Hull, D., Pettifer, S. R. & Kell, D. B. (2008). Defrosting the digital library: bibliographic tools for the next generation web. PLoS Comput Biol 4, e1000204. doi:10.1371/journal.pcbi.1000204. Link to an OA commentary at Nature showing very high number of accesses. PMID 18974831.

Dobson, P. D. & Kell, D. B. (2008). Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule? Nat Rev Drug Discov, 7, 205-220. Supplementary Information. Link to journal. PMID 18309312.

Wedge, D. & Kell, D. B. (2008). Rapid prediction of optimum population size in genetic programming using a novel genotype – fitness correlation. GECCO 2008 (M. Keizer et al., eds), 1315-1322. (Nominated for best paper.)

Farrelly, C., Kell, D. B. & Knowles, J. (2008). Predicting molecular structure using ant colony optimization: a preliminary study. LNCS 5217, 120-131

Herrgård, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Blüthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novère, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttilä, M., Klipp, E., Palsson, B. Ø., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J. & Kell, D. B. (2008). A consensus yeast metabolic network obtained from a community approach to systems biology. Nature Biotechnol. 26, 1155-1160. PMID 18846089.

Yisu, J., Knowles, J., Hongmei, L., Yizeng, L. & Kell, D. B. (2008). The landscape adaptive particle swarm optimizer. Applied Soft Computing J 8, 295-304

Yue, H., Brown, M., He, F., Jia, J. & Kell, D. B. (2008). Sensitivity analysis and robust experimental design of a signal transduction pathway system. Int J Chem Kinet 40, 730-741

Heazell, A. E. P., Brown, M., Dunn, W. B., Worton, S. A., Crocker, I. P., Baker, P. N. & Kell, D. B. (2008). Analysis of the metabolic footprint and tissue metabolome of placental villous explants cultured at different oxygen tensions reveals novel redox biomarkers. Placenta 29, 691-698. PMID 18573524.

Dunn, W. B., Broadhurst, D., Brown, M., Baker, P. N., Redman, C. W. G., Kenny, L. C. & Kell, D. B. (2008). Metabolic profiling of mammalian serum using Ultra Performance Liquid Chromatography and the LTQ-Orbitrap mass spectrometry system. J Chromatogr B, 871, 288-298. PMID 18420470.

Li, P., Castrillo, J. I., Velarde, G., Wassink, I., Soiland-Reyes, S., Owen, S., Withers, D., Oinn, T., Pocock, M. R., Goble, C. A., Oliver, S. G. & Kell, D. B. (2008). Performing statistical analyses on quantitative data in Taverna workflows: an example using R and maxdBrowse to identify differentially expressed genes from microarray data. BMC Bioinformatics 9, 334. PMID 18687127.

Kell, D. B. (2008). Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases. Preprint (159pp):http://arxiv.org/abs/0808.1371

Kenny, L. C., Broadhurst, D., Brown, M., Dunn, W. B., Redman, C. W., Kell, D. B. & Baker, P. N. (2008). Detection and identification of novel metabolomic biomarkers in preeclampsia. Reprod Sci 15, 591-7. PMID 18492697.

Kell, D. B. & Mendes, P. (2008). The markup is the model: reasoning about systems biology models in the Semantic Web era. J Theoret Biol, 252, 538-543. PMID 18054049.

Spasić, I., Schober, D., Sansone, S., Rebholz-Schuhmann, D., Kell, D.B. & Paton, N.W. (2008) Facilitating the development of controlled vocabularies for metabolomics technologies with text mining. BMC Bioinformatics, 9, S5. PMID 18460187.

Lu, H., Dunn, W. B., Shen, H., Kell, D. B. & Liang, Y. (2008). Comparative evaluation of software for deconvolution of metabolomics data based on GC-TOF-MS. Trends Anal Chem 27, 215-227

Dunn, W. B., Broadhurst, D., Ellis, D. I., Brown, M., Ashworth, J., Cameron, M., Halsall, A., O’Hagan, S., Spasic, I., Tseng, A. & Kell, D. B. (2008). A GC-TOF-MS study of the stability of serum and urine metabolomes during the UK Biobank sample collection and preparation protocols. Int J Epidemiol 2007, 1-8. PMID 18381390.

Jayawardhana, B., Kell, D.B. & Rattray, M. (2008) Bayesian inference of the sites of perturbations in metabolic pathways via Markov Chain Monte Carlo. Bioinformatics, doi: 10.1093/bioinformatics/btn103. PMID 18356193.

Peiris, D., Dunn, W. B., Brown, M., Kell, D. B., Roy, I. & Hedger, J. N. (2008). Metabolite profiles of interacting mycelial fronts differ for pairings of the wood decay basidiomycete fungus Stereum hirsutum with its competitors Coprinus micaceus and Coprinus disseminatus. Metabolomics 4, 52-62

Li, P., Oinn, T., Stoiland, S. & Kell, D. B. (2008). Automated manipulation of systems biology models using libSBML within Taverna workflows. Bioinformatics 24, 287-289. PMID 18056069.

Delneri, D., Hoyle, D. C., Gkargkas, K., Cross, E. J., Rash, B., Zeef, L., Leong, H. S., Davey, H. M., Hayes, A., Kell, D. B., Griffith, G. W. & Oliver, S. G. (2008). Identification and characterization of high-flux-control genes of yeast through competition analyses in continuous cultures. Nat Genet 40, 113-7. PMID 18157128.

Wilkinson, S. J., Benson, N. & Kell, D. B. (2008). Proximate parameter tuning for biochemical networks with uncertain kinetic parameters. Mol Biosyst, 10.1039/b707506e. Enhanced HTML at RSC. PMID 18075678.

Lüdtke, N., Panzeri, S., Brown, M., Broomhead, D. S., Knowles, J., Montemurro, M. A. & Kell, D. B. (2008). Information-theoretic Sensitivity Analysis: a general method for credit assignment in complex networks. J Roy Soc Interface 5, 223-235. PMID 17594961.

Smallbone, K., Simeonidis, E., Broomhead, D. S. & Kell, D. B. (2007). Something from nothing: bridging the gap between constraint-based and kinetic modelling.FEBS J 274, 5576-5585. PMID 17922843.

Kell, D. B. (2007). The virtual human: towards a global systems biology of multiscale, distributed biochemical network models. IUBMB Life 59, 689-95. PMID 17968707.

Goodacre, R., Broadhurst, D., Smilde, A., Kristal, B. S., Baker, J. D., Beger, R., Bessant, C., Connor, S., Capuani, G., Craig, A., Ebbels, T., Kell, D. B., Manetti, C., Newton, J., Paternostro, G., Somorjai, R., Sjöström, M., Trygg, J. & Wulfert, F. (2007). Proposed minimum reporting standards for data analysis in metabolomics. Metabolomics 3, 231-241

Pope, G. A., MacKenzie, D. A., Defemez, M., Aroso, M., Fuller, L. J., Mellon, F. A., Dunn, W. B., Brown, M., Goodacre, R., Kell, D. B., Marvin, M. E., Louis, E. J. & Roberts, I. N. (2007). Metabolic footprinting as a tool for discriminating between brewing yeasts. Yeast 24, 667-679. PMID 17534862.

Yisu, J., Knowles, J., Hongmei, L., Yizeng, L. & Kell, D. B. (2007).The landscape adaptive particle swarm optimizer. Applied Soft Computing J 8, 295-304.

Kell, D. B. (2007).Metabolomic biomarkers: search, discovery and validation. Exp Rev Mol Diagnost 7, 329-333. PMID 17620040.

Wedge, D., Gaskell, S. J., Hubbard, S., Kell, D. B., Lau, K. W. & Eyers, C. (2007). Peptide detectability following ESI mass spectrometry: prediction using genetic programming. In GECCO 2007 (ed. D. Thierens et al.), pp. 2219-2225. ACM, New York.

Handl, J., Kell, D. B. & Knowles, J. (2007). Multiobjective optimization in bioinformatics and computational biology. IEEE Trans Comput Biol Bioinformatics 4, 279-292. PMID 17473320.

Westerhoff, H. V. & Kell, D. B. (2007). The methodologies of systems biology. In Systems biology: philosophical foundations (ed. F. C. Boogerd, F. J. Bruggeman, J.-H. S. Hofmeyr and H. V. Westerhoff), pp. 23-70. Elsevier, Amsterdam.

Castrillo, J. I., Zeef, L. A., Hoyle, D. C., Zhang, N., Hayes, A., Gardner, D. C. J., Cornell, M. J., Petty, J., Hakes, L., Wardleworth, L., Rash, B., Brown, M., Dunn, W. B., Broadhurst, D., O’Donoghue, K., Hester, S. S., Dunkley, T. P. J., Hart, S. R., Swainston, N., Li, P., Gaskell, S. J., Paton, N. W., Lilley, K. S., Kell, D. B. & Oliver, S. G. (2007). Growth control of the eukaryote cell: a systems biology study in yeast. J. Biol 6, 4. See also commentary. Most accessed article of the year in December 2007. PMID 17439666.

Oinn, T., Li, P., Kell, D. B., Goble, C., Goderis, A., Greenwood, M., Hull, D., Stevens, R., Turi, D. & Zhao, J. (2007). Taverna /^myGrid: aligning a workflow system with the life sciences community. In Workflows for e-Science: scientific workflows for Grids (ed. I. J. Taylor, E. Deelman, D. B. Gannon and M. Shields), pp. 300-319. Springer, Guildford

O’Hagan, S., Dunn, W. B., Broadhurst, D., Williams, R., Ashworth, J. A., Cameron, M., Knowles, J. & Kell, D. B. (2007). Closed-loop, multi-objective optimisation of two-dimensional gas chromatography (GCxGC-tof-MS) for serum metabolomics. Anal Chem 79, 464-476. PMID 17222009.

Ananiadou, S., Kell, D. B. & Tsujii, J.-i. (2006). Text Mining and its potential applications in Systems Biology. T rends Biotechnol 24, 571-579. PMID 17045684.

Kell, D.B. (2006) Systems biology, metabolic modelling and metabolomics in drug discovery and development Drug Discovery Today, 11, 1085-1092. PMID 17129827.

Shen, H., Nelson, G., Nelson, D.E., Kennedy, S., Spiller, D.G., Griffiths, T., Paton, N., Oliver, S.G., White, M.R.H., Kell, D.B. (2006) Automated tracking of gene expression in individual cells and cell compartments Journal of the Royal Society Interface, 3, 787-794. [web site.] PMID 17015304.

Yue, H., Brown, M., Knowles, J., Wang, H., Broomhead, D.S. & Kell, D.B. (2006) Insights into the behaviour of systems biology models from dynamic sensitivity and identifiability analysis: a case study of an NF-κ -B signalling pathway. Molecular BioSystems, 2, 640-649. PMID 17216045.

Spasic, I., Dunn, W., Velarde, G., Tseng, A., Jenkins, H., Hardy, N.W., Oliver, S.G. & Kell, D.B. (2006) MeMo: a hybrid SQL/XML approach to metabolomic data management for functional genomics. BMC Bioinformatics, 7, 281. [web site.] PMID 16753052.

Shen, H., Nelson, G., Kennedy, S., Nelson, D., Johnson, J., Spiller, D., White, M.R.H. & Kell, D.B. (2006) Automatic tracking of biological cells and compartments using particle filters and active contours. Chemometrics and Intelligent Laboratory Systems 82, 276 282. [web site]

Underwood, B.R., Broadhurst, D., Dunn, W.B., Ellis, D.I., Michell, A.W., Vacher, C., Mosedale, D.E., Kell, D.B., Barker, R., Grainger, D.J. & Rubinsztein, D.C. (2006) Huntington disease patients and transgenic mice have similar pro-catabolic serum metabolite profiles. Brain 129, 877-886. PMID 16464959.

Kell, D.B. & Knowles, J.D. (2006) The role of modeling in systems biology. In System modeling in cellular biology: from concepts to nuts and bolts (ed. Z. Szallasi, J. Stelling and V. Periwal), pp. 3-18. MIT Press, Cambridge.

Kell, D.B. (2006) Metabolomics, modelling and machine learning in systems biology towards an understanding of the languages of cells. The 2005 Theodor Bücher lecture. The FEBS Journal 273, 873-894. PMID 16478464.

Mukamolova, G.V., Murzin, A.G., Salina, E.G., Demina, G.R., Kell, D.B., Kaprelyants, A.S. & Young, M. (2006) Muralytic activity of Micrococcus luteus Rpf and its relationship to physiological activity in promoting bacterial growth and resuscitation. Molecular Microbiology 59, 84-98. PMID 16359320.

Ihekwaba, A.E.C., Broomhead, D.S., Grimley, R., Benson, N., White, M.R.H. & Kell, D.B. (2005). Synergistic control of oscillations in the NF-κB signalling pathway. IEE Systems Biology, 152, 153-160. PMID 16986278.

Vaidyanathan, S., Jones, D., Broadhurst, D.I., Ellis, J., Jenkins, T., Dunn, W.B., Hayes, A., Burton, N., Oliver, S.G., Kell, D.B. & Goodacre, R. (2005). A laser desorption ionisation mass spectrometry approach for high throughput metabolomics. Metabolomics, 1(3), 243-250. DOI: 10.1007/s11306-005-0007-x.

Hancock, D., Wilson, M., Velarde, G., Morrison, N., Hayes, A., Hulme, H., Wood, A.J., Nashar, K., Kell, D.B. & Brass, A. (2005) maxdLoad2 and maxdBrowse:standards-compliant tools for microarray experimental annotation, data management and dissemination. BMC Bioinformatics, 6, 264. PMID 16269077.

Catchpole, G.S., Beckmann, M., Enot, D.P., Mondhe, M., Zywicki, B., Taylor, J., Hardy, N., Smith, A., King, R.D., Kell, D.B., Fiehn, O. & Draper, J. (2005) Hierarchical metabolomics demonstrates substantial compositional similarity between genetically modified and conventional potato crops. Proc Natl Acad Sci U S A 102, 14458-62. PMID 16186495.

Handl, J., Knowles, J. & Kell, D.B. (2005) Computational cluster validation in post-genomic data analysis. Bioinformatics, 21, 3201-3212. PMID 15914541.

Kell, D.B., Brown, M., Davey, H.M., Dunn, W.B., Spasic, I. & Oliver, S.G. (2005) Metabolic footprinting and systems biology: the medium is the message. Nat Rev Microbiol, 3, 557-565. PMID 15953932.

Kell, D.B. (2005) Metabolomics, machine learning and modelling: towards an understanding of the language of cells. Biochem Soc Trans 33, 520-524. PMID 15916555.

Pritchard, L., Corne, D., Kell, D.B., Rowland, J. & Winson, M. (2005) A general model of error-prone PCR. Journal of Theoretical Biology 234, 497509.

Johnson, H.E., Merry, R.J., Davies, D.R., Kell, D.B., Theodorou, M.K. & Griffith, G.W. (2005) Vacuum packing: a model system for laboratory-scale silage fermentations. J Appl Microbiol 98, 106-113. PMID 15610422.

Brown, M., Dunn, W.B., Ellis, D.I., Goodacre, R., Handl, J., Knowles, J.D., O’Hagan, S., Spasic, I. & Kell, D.B. (2005) A metabolome pipeline: from concept to data to knowledge. Metabolomics 1(1), 39-51.

O’Hagan, S., Dunn, W.B., Brown, M., Knowles, J.D. & Kell, D.B. (2005) Closed-loop, multiobjective optimization of analytical instrumentation: gas chromatography/time-of-flight mass spectrometry of the metabolomes of human serum and of yeast fermentations. Anal. Chem 77, 290-303. PMID 15623308.

Jenkins, H., Hardy, N., Beckmann, M., Draper, J., Smith, A.R., Taylor, J., Fiehn, O., Goodacre, R., Bino, R.J., Hall, R., Kopka, J., Lane, G.A., Lange, B.M., Liu, J.R., Mendes, P., Nikolau, B.J., Oliver, S.G., Paton, N.W., Rhee, S., Roessner-Tunali, U., Saito, K., Smedsgaard, J., Sumner, L.W., Wang, T., Walsh, S., Syrkin Wurtele, E. & Kell, D.B. (2004) A proposed framework for the description of plant metabolomics experiments and their results. Nature Biotechnol. 22(12), 1601-1606. PMID 15583675.

Ihekwaba, A., Broomhead, D.S., Grimley, R., Benson, N. & Kell, D.B. (2004) Sensitivity analysis of parameters controlling oscillatory signalling in the NF-kappaB pathway: the roles of IKK and IkappaBa. Systems Biology 1, 93-103. PMID 17052119.

Zhao, H., Kassama, Y., Young, M., Kell, D.B. & Goodacre, R. (2004) Differentiation of Micromonospora isolates from a coastal sediment in Wales based on Fourier transform infrared spectroscopy, 16S rDNA sequence analysis, and the amplified fragment length polymorphism technique. Appl. Env. Microbiol. 70, 6619-8827. PMID 15528526.

Nelson, D. E., Ihekwaba, A. E. C., Elliott, M. , Johnson, J. R., Gibney, C. A., Foreman, B. E., Nelson, G., See, V., Horton, C. A., Spiller, D. G., Edwards, S. W., McDowell, H. P., Unitt, J. F., Sullivan, E., Grimley, R., Benson, N., Broomhead, D., Kell, D. B. & White, M. R. H. (2004) Oscillations in NF-B Signaling Control the Dynamics of Gene Expression. Science 306, 704-708. PMID 15499023.

Allen, J., Davey, H.M., Broadhurst, D., Rowland, J.J., Oliver, S.G. & Kell, D.B. (2004) Discrimination of modes of action of antifungal substances by use of metabolic footprinting. Appl Env Microbiol 70(10), 61576165. PMID 15466562.

Vaidyanathan, S., Kell, D.B. & Goodacre, R. (2004) Selective detection of proteins in mixtures using electrospray ionization mass spectrometry: influence of instrumental settings and implications for proteomics. Anal. Chem. 76, 5024-5032. PMID 15373437.

Kell, D. B., Woodward, A. M., Davies, E. A., Todd, R. W., Evans, M. F., Rowland, J. J. (2004) Nonlinear dielectric spectroscopy of biological systems: principles and applications. Nonlinear Phenomena in Complex Liquids, Kluwer Academic Publishers, 335-344.

Kell, D. B. (2004) Metabolomics and systems biology: making sense of the soup. Curr Opin Microbiol 7(3), 296-307. PMID 15196499.

Woodward, A. M., Rowland, J. J. & Kell, D. B. (2004) Fast automatic registration of images using the phase of a complex wavelet transform: application to proteome gels. Analyst 129, 542-552. PMID 15152333.

White, T. A. & Kell, D. B. (2004) Comparative genomic assessment of novel broad-spectrum targets for antibacterial drugs. Comp. Func. Genomics 5, 304-327. PMID 18629165.

Goodacre, R., Vaidyanathan, S., Dunn, W.B., Harrigan, G.G. & Kell, D.B. (2004) Metabolomics by numbers: acquiring and understanding global metabolite data. Trends. Biotechnol. 22, 245-252. PMID 15109811.

Johnson, H.E., Broadhurst, D., Kell, D.B., Theodorou, M.K., Merry, R.J. & Griffith, G.W. (2004) High-Throughput Metabolic Fingerprinting of Legume Silage Fermentations via Fourier Transform Infrared Spectroscopy and Chemometrics. Appl. Env.Microbiol. 70, 1583-1592. PMID 15006782.

Twist, C. R., Winson, M. K., Rowland, J. J. & Kell, D. B. (2004) SNP detection using nanomolar nucleotides and single molecule fluorescence. Anal. Biochem. 327, 35-44. PMID 15033508.

King, R.D., Whelan, K.E., Jones, F.M., Reiser, P.G.K., Bryant, C.H., Muggleton, S.H., Kell, D.B. & Oliver, S.G. (2004) Functional genomic hypothesis generation and experimentation by a robot scientist. Nature 427, 247-252. PMID 14724639.

Kell, D.B. & Oliver, S.G. (2004) Here is the evidence, now what is the hypothesis? The complementary roles of inductive and hypothesis-driven science in the post-genomic era. Bioessays 26, 99-105. PMID 14696046.

Vaidyanathan, S., Broadhurst, D. I., Kell, D. B. & Goodacre, R. (2003) Explanatory optimisation of protein mass spectrometry via genetic search. Anal. Chem. 75, 6679-6686. PMID 14640745.

Kell, D. B., Mukamolova, G. V., Finan, C. L., Zhao, H., Goodacre, R., Kaprelyants, A. S. & Young, M. (2003) Resuscitation of ‘uncultured’ microorganisms. In Microbial diversity and bioprospecting (ed. A. T. Bull), pp. 100-108. American Society for Microbiology, Washington, DC.

Mukamolova, G. V., Kaprelyants, A. S., Kell, D. B. & Young, M. (2003) Adoption of the transiently non-culturable state – a bacterial survival strategy? Adv. Micr. Physiol. 47, 65-129. PMID 14560663.

Allen, J. K., Davey, H. M., Broadhurst, D., Heald, J. K., Rowland, J. J., Oliver, S. G. & Kell, D. B. (2003) High-throughput classification of yeast mutants for functional genomics using metabolic footprinting. Nature Biotechnol. 21, 692-696. PMID 12740584.

Taylor, C. F., Paton, N. W., Garwood, K. L., Kirby, P. D., Stead, D. A., Yin, Z., Deutsch, E. W., Selway, L., Walker, J., RibaGarcia, I., Mohammed, S., Deery, M. J., Howard, J. A., Dunkley, T., Aebersold, R., Kell, D. B., Lilley, K. S., Roepstorff, P., Yates, J. R., Brass, A., Brown, A. J. P., Cash, P., Gaskell, S. J., Hubbard, S. J. & Oliver, S. G. (2003) A systematic approach to modelling capturing and disseminating proteomics experimental data. Nat Biotechnol 21, 247-254. PMID 12610571.

Goodacre, R. & Kell, D. B. (2003) Evolutionary computation for the interpretation of metabolome data. In Metabolic profiling: its role in biomarker discovery and gene function analysis (ed. G. G. Harrigan and R. Goodacre), pp. 239-256. Kluwer Academic Publishers, Boston.

Corne, D. W., Oates, M. J. & Kell, D. B. (2003) Landscape State Machines: tools for evolutionary algorithm performance analyses and landscape/algorithm mapping. In Evoworkshops 2003, vol. LNCS 2611 (ed. S. Cagnoni, et al.), pp. 187-198. Springer, Berlin.

Corne, D. W., Oates, M. J. & Kell, D. B. (2003) Fitness gains and mutation patterns: deriving mutation rates by exploiting landscape data. In Foundations of Genetic Algorithms 7 (ed. K. A. De Jong, R. Poli and J. E. Rowe), pp. 347-364. Morgan Kaufmann, Amsterdam.

Kaderbhai, N. N., Broadhurst, D. I., Ellis, D. I., Goodacre, R. & Kell, D. B. (2003) Functional genomics via metabolic footprinting: Monitoring metabolite secretion by Escherichia coli tryptophan metabolism mutants using FT-IR and direct injection electrospray mass spectrometry. Comp. Func. Genomics 4, 376-391. PMID 18629082.

Hesketh, A. R., Chandra, G., Shaw, A. D., Rowland, J. J., Kell, D. B., Bibb, M.J. & Chater, K. F. (2002) Primary and secondary metabolism, and post-translational protein modifications, as portrayed by proteomic analysis of Streptomyces coelicolor. Mol. Microbiol. 46, 917-932. PMID 12421300.

Kell, D. B. (2002) Genotype-phenotype mapping: genes as computer programs. Trends Genet 18, 555-9. PMID 12414184.

Mukamolova, G. V., Turapov, O. A., Young, D. I., Kaprelyants, A. S., Kell, D. B. & Young, M. (2002) A family of autocrine growth factors in Mycobacterium tuberculosis. Mol. Microbiol. 46, 623-635. PMID 12410821.

Mukamolova, G. V., Turapov, O. A., Kazaryan, K., Telkov, M., Kaprelyants, A. S., Kell, D. B. & Young, M. (2002) The rpf gene of Micrococcus luteus encodes an essential secreted growth factor. Mol. Microbiol. 46, 611-621. PMID 12410820.

Corne, D.W., Oates, M.J. & Kell, D.B. (2002) On fitness distributions and expected fitness gain of mutation rates in parallel evolutionary algorithms. In Parallel Problem Solving from Nature – PPSN VII. (eds. J.J. Merelo Guervós, P. Adamidis, H.-G. Beyer, J.-L. Fernández-Villacañas & H.-P. Schwefel) 132-141 (Springer, Berlin; 2002).

Kell, D.B. (2002) Metabolomics and machine learning: explanatory analysis of complex metabolome data using genetic programming to produce simple, robust rules. Mol. Biol. Rep. 29, 237-242. PMID 12241064.

Groeneveld, P., Rolley, N., Kell, D.B., Kelly, S.L. & Kelly, D.E. (2002) Metabolic control analysis and engineering of the yeast sterol biosynthetic pathway. Mol. Biol. Rep. 29, 27-29. PMID 12241069.

Pritchard, L. & Kell, D.B. (2002) Schemes of flux control in a model of Saccharomyces cerevisiae glycolysis. Eur. J. Biochem. 269, 3894-3904. PMID 12180966.

Lamb, D.C., Skaug, T., Song, H.L., Jackson, C.J., Podust, L.M., Waterman, M.R., Kell, D.B., Kelly, D.E. & Kelly, S.L. (2002) The cytochrome P450 complement (CYPome) of Streptomyces coelicolor A3(2). J. Biol. Chem. 277, 24000-5. PMID 11943767.

Vaidyanathan, S., Winder, C.L., Wade, S.C., Kell, D.B. & Goodacre, R. (2002) Sample preparation in matrix-assisted laser desorption ionization mass spectrometry of whole bacterial cells and the detection of high mass (>20 kDa) proteins. Rapid Comm. Mass Spectrom. 16:1276-1286. PMID 12112255.

Ellis, D. I., Broadhurst, D., Kell, D.B, Rowland, J.J. & Goodacre, R. (2002) Rapid and quantitative detection of the microbial spoilage of meat using Fourier-Transform infrared spectroscopy and machine learning. Appl. Env. Microbiol. 68, 2822-2888. Abstract Pubmed. Abstract ASM. Full text at ASM. PMID 12039738.

McGovern, A.C., Broadhurst, D., Taylor, J., Gilbert, R.J.,Winson, M.K., Kaderbhai, N., Smal, D.A., Rowland, J.J., Kell, D.B. and Goodacre, R. (2002) Monitoring of complex industrial bioprocesses for metabolite concentrations using modern spectroscopies and machine learning: application to gibberellic acid production. Biotechnol. Bioeng. 78, 527-538. PMID 12115122.

Shleeva, M.O., Bagramyan, K., Telkov, M.V., Mukamolova, G.V., Young, M., Kell, D.B. and Kaprelyants, A.S. (2002) Formation and resuscitation of “non-culturable” cells of Rhodococcus rhodochrous and Mycobacterium tuberculosis in prolonged stationary phase. Microbiology 148, 1581-1591. Full text at SGM. PMID 11988533.

Kell, D. B. (2002) Defence against the flood: a solution to the data mining and predictive modelling challenges of today. Bioinformatics World (part of Scientific Computing News) Issue 1, 16-18. manuscript

Day, J.P., Kell, D.B. & Griffith, G.W. (2002) Differentiation of Phytophthora infestans sporangia from other airborne biological particles by flow cytometry. Appl. Env. Microbiol. 68, 37-45. Abstract. Full text at AEM. PMID 11772606.

Vaidyanathan S., Kell D.B. & Goodacre R. (2002) Flow-injection electrospray ionization mass spectrometry of crude cell extracts for high-throughput bacterial identification. J Am Soc Mass Spectrom 13(2), 118-128. PMID 11838015.

Bryant CH, Muggleton SH, Oliver SG, Kell DB, Reiser P, King RD (2001) Combining active inductive programming, active learning and robotics to discover the function of genes. Electronic Trans. Artif. Intell., 5, 1-36. preprint; final

Woodward, A.M., Kaderbhai, N., Kaderbhai, M., Shaw, A.D., Rowland, J.J. & Kell, D.B. (2001) Histometrics: improvement of the dynamic range of fluorescently stained proteins resolved in electrophoretic gels using hyperspectral imaging. Proteomics 1, 1351-1358. PMID 11922594.

Vaidyanathan, S., Rowland, J.J., Kell, D.B. & Goodacre, R. (2001) Discrimination of aerobic endospore-forming bacteria via electrospray ionization mass spectrometry of whole cell suspensions. Anal. Chem. 73, 4134-4144. Abstract. PMID 11569802.

Kell, D.B., Darby, R.M. & Draper, J. (2001) Genomic computing: explanatory analysis of plant expression profiling data using machine learning. Plant Physiology 126, 943.951. Abstract. Full paper at Plant Physiology. PMID 11457944.

Weichart, D.H. & Kell, D.B. (2001) Characterization of an autostimulatory substance produced by Escherichia coli. Microbiology 147, 1875-1885. Abstract. Full text at SGM . PMID 11429464.

Bianchi, G., Giansante, L., Shaw, A.D. & Kell, D.B. (2001) Chemometric criteria for the characterisation of Italian DOP olive oils from their metabolic profiles. Eur. J. Lipid. Sci. Technol. 103, 141-150.

Mendes, P. & Kell, D.B. (2001) MEG (Model Extender for Gepasi): a program for the modelling of complex, heterogeneous, cellular systems. Bioinformatics 17, 288-289. PMID 11294797.

Clegg, J., Kell, D., Knull, H., Welch, G.R., Wilson, J. (2001) Macromolecular interactions: tracing the roots. Trends Biochem. Sci 26, 91.

Raamsdonk, L. M., Teusink, B., Broadhurst, D., Zhang, N., Hayes, A., Walsh, M., Berden, J. A., Brindle, K. M., Kell, D. B., Rowland, J. J., Westerhoff, H. V., van Dam, K. & Oliver, S. G. (2001) A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations. Nature Biotechnology 19, 45-50. PMID 11135551.

Biketov, S., Mukamolova, G. V., Potapov, V., Gilenkov, E., Vostroknutova, G., Kell, D. B., Young, M. & Kaprelyants, A. S. (2000) Culturability of Mycobacterium tuberculosis cells isolated from murine macrophages: a bacterial growth factor promotes recovery. FEMS Immunol. Med. Microbiol. 29, 233-240. PMID 11118902.

Johnson, H.E., Gilbert, R.J., Winson, M.K., Goodacre, R., Smith, A.R., Rowland, J.J., Hall, M.A. & Kell, D.B. (2000) Explanatory analysis of the metabolome using genetic programming of simple, interpretable rules. Genetic Programming and Evolvable Machines 1, 243-258.

Barer M., Bogosian G., Kell D. & Williams, H. (2000) Resuscitating a logical approach to viability in the face of an “eastern wind” ASM News 66, 381-382. [Letter]

Wixon, J. & Kell, D.B. (2000) Website review – The Kyoto Encyclopedia of Genes and Genomes – KEGG – http://www.genome.ad.jp/kegg. Yeast 17, 48-55.

Gilbert, R. J., Rowland, J. J. & Kell, D. B. (2000) Genomic computing: explanatory modelling for functional genomics. In Proceedings of the Genetic and Evolutionary Computation Conference (GECCO-2000) (ed. D. Whitley, D. Goldberg, E. Cantú-Paz, L. Spector, I. Parmee and H.-G. Beyer), pp. 551-557. Morgan Kaufmann, San Francisco. pdf version of ms here.

Davey, H. M., and Kell, D. B. (2000) A portable flow cytometer for the detection and identification of microorganisms. In: Rapid Methods for Monitoring the Environment for Biological Hazards, Eds. P. J. Stopa and M. A. Bartoszcze, Kluwer Academic Publishers, Dordrecht, 159-167.

Goodacre, R., Burton, R., Kaderbhai, N, Timmins, É.M., Woodward, A., Rooney, P.J. & Kell, D.B. (2000) Intelligent systems for the characterisation of microorganisms from hyperspectral data. In Rapid Methods for the Analysis of Biological Materials in the Environment. Eds. P.J. Stopa & M.A. Bartoszcze, Kluwer Academic Publishers, Dordrecht, 111-136.

Kaprelyants, A. S., Mukamolova, G. V., Votyakova, T. V., Davey, H. M., and Kell, D. B. (2000) Dormancy in non-sporulating bacteria: its significance for environmental monitoring. Rapid Methods for Monitoring the Environment for Biological Hazards, P. J. Stopa and M. A. Bartoszcze, eds., Kluwer Academic Publishers, Dordrecht, 49-65.

Yardley, J.E., Todd, R.W., Nicholson, D.J., Barrett, J., Kell, D.B. & Davey, C.L. (2000) Correction of the influence of baseline artefacts and electrode polarisation on dielectric spectra. Bioelectrochem. Bioenerg. 51, 53-65. PMID 10790780.

Kell, D.B. & Young, M. (2000) Bacterial dormancy and culturability: the role of autocrine growth factors. Curr. Opin. Microbiol. 3, 238-243. PMID 10851153.

Kell, D.B. (2000) Screen idols – faster, smaller, cheaper and smarter. [meeting report] Trends Biotechnol. 18, 186-187. Journal ref. PMID 10917679.

Woodward, A.M., Davies, E.A., Denyer, S., Olliff, C. & Kell, D.B. (2000) Non-linear dielectric spectroscopy: antifouling and stabilisation of electrodes by a polymer coating. Bioelectrochemistry 51, 13-20. PMID 10790775.

Davies, Z.S., Gilbert, R.J., Merry, R.J., Kell, D.B., Theodorou, M.K. & Griffith, G.W. (2000) Efficient improvement of silage additives using genetic algorithms. Appl. Env. Microbiol. 66, 1435-1443. PMID 10742224.

Kell, D.B. & King, R.D. (2000) On the optimization of classes for the assignment of unidentified reading frames in functional genomics programmes: the need for machine learning. Trends Biotechnol. 18, 93-98. PMID 10675895.

Davies, E., Woodward, A.M. & Kell, D.B. (2000) The use of nonlinear dielectric spectroscopy to monitor the bioelectromagnetic effects of a weak pulsed magnetic field in real time. Bioelectromagnetics 21, 25-33. 30

Goodacre, R., Shann, B., Gilbert, R.J., Timmins, É.M., McGovern, A., Alsberg, B.K., Kell, D.B. & Logan, N.A. (2000) The detection of the dipicolinic acid biomarker in Bacillus spores using Curie-point pyrolysis mass spectrometry and Fourier-transform infrared spectroscopy. Anal. Chem. 72, 119-127. PMID 10655643.

Shaw, A.D., Winson, M.K., Woodward, A.M., McGovern, A., Davey, H.M., Kaderbhai, N., Broadhurst, D.I., Gilbert, R.J., Taylor, J., Timmins, É.M., Alsberg, B.K., Rowland, J.J., Goodacre, R. & Kell, D.B. (2000) Rapid analysis of high-dimensional bioprocesses using multivariate spectroscopies and advanced chemometrics. Adv. Biochem. Eng. 66, 83-113. PMID 10592527.

Shaw, A.D., Kaderbhai, N., Jones, A., Woodward, A.M., Goodacre, R., Rowland, J.J. & Kell, D.B. (1999) Non-invasive, on-line monitoring of the biotransformation by yeast of glucose to ethanol using dispersive Raman spectroscopy and chemometrics. Appl. Spectroscopy. 53, 1419-1428.

Vlahov, G., Shaw, A.D. & Kell, D.B. (1999) Use of ¹³C NMR DEPT pulse sequence and multivariate analysis to discriminate olive oil cultivars. J. Amer. Oil Chemists Soc., 76, 1223-1231.

Mukamolova, G.V., Kormer, S.S., Kell, D.B. & Kaprelyants, A.S. (1999) Stimulation of the multiplication of Micrococcus luteus by an autocrine growth factor. Arch.Microbiol. 172, 9-14. PMID 10398746.

McGovern, A.C., Ernill, R., Kara, B.V., Kell, D.B. & Goodacre, R. (1999) Rapid analysis of the expression of heterologous proteins in Escherichia coli using pyrolysis mass spectrometry and Fourier transform infrared spectroscopy with chemometrics: application to alpha2-interferon production. J. Biotechnol. 72, 157-167. PMID 10443022.

Goodacre, R. Heald, J.K. & Kell, D.B. (1999) Characterisation of intact microorganisms using electrospray ionisation mass spectrometry. FEMS Microbiology Letters 176, 17-24.

Woodward, A.M., Gilbert, R.J. & Kell, D.B. (1999) Genetic programming as an analytical tool for non-linear dielectric spectroscopy. Bioelectrochem. Bioenerg. 48, 389-396. PMID 10379559.

Gilbert, R.J., Johnson, H.E., Winson, M.K., Rowland, J.J., Goodacre, R., Smith, A.R., Hall, M.A. & Kell, D. B. (1999) Genetic programming as an analytical tool for metabolome data. Langdon, W.B., Poli, R., Nodin, P. & Fogarty, T. (eds) Late-breaking papers of EuroGP-99, pp. 23-33.

Davies, E., Olliff, C., Wright, I., Woodward, A. & Kell, D.B. (1999) A weak pulsed magnetic field affects adenine nucleotide oscillations and related parameters in aggregating Dictyostelium discoideum amoebae. Bioelectrochem. Bioenerg. 48, 149-162.

Davey, H.M., Kaprelyants, A.S., Weichart, D.H. and Kell, D.B. (1999) Approaches to the estimation of microbial viability using flow cytometry. In: Current Protocols in Cytometry: Volume 11 Microbial Cytometry, pp. 11.3.1-11.3.20 . Robinson, J.P. (Ed.) Wiley, New York.

Kaprelyants, A.S., Mukamolova, G.V., Kormer, S.S., Weichart, D.H., Young, M. & Kell, D.B. (1999) Intercellular signalling and the multiplication of prokaryotes: bacterial cytokines. Symp. Soc. Gen. Microbiol. 57, 33-69.

Kell, D. B. (1999) Revolutionary ideas come round again. Nature 397, 644. PMID 10067885.

Kell, D.B. (1999) Screensavers: trends in high-throughput analysis [meeting report]. Trends in Biotechnol. 17, 89-91.

Kell, D.B. (1999) Nonviable and nonculturable [letter]. ASM News 65(1), 1.

Davey H.M., Jones A., Shaw A.D. and Kell D.B. (1999) Variable selection and multivariate methods for the identification of microorganisms by flow cytometry. Cytometry 35, 162-168. PMID 10554172.

Goshawk, J.A., Binding, D.M., Kell, D.B. & Goodacre, R. (1998) Rheological phenomena occurring during the shearing flow of mayonnaise. J. Rheology 42, 1537-1553.

Kell, D.B. (1998) From code to mode for orphan genes. [Meeting report]. Trends Biotechnol. 16, 491-493.

Alsberg, B.K., Kell, D.B. & Goodacre, R. (1998) Variable selection in discriminant partial least squares analysis. Anal. Chem., 70, 4126-4133. PMID 21651249.

Davey, C.L. & Kell, D.B. (1998) The influence of electrode polarisation on dielectric spectra, with special reference to capacitive biomass measurements. II. reduction in the contribution of electrode polarisation to dielectric spectra using a two-frequency method. Bioelectrochem. Bioenerg. 46, 105-114.

Davey, C.L. & Kell, D.B. (1998) The influence of electrode polarisation on dielectric spectra, with special reference to capacitive biomass measurements. I. quantifying the effects on electrode polarisation of factors likely to occur during fermentations. Bioelectrochem. Bioenerg. 46, 91-103.

Mendes, P. & Kell, D.B. (1998) Numerical optimisation and simulation for rational metabolic engineering. In BioThermoKinetics in the post-genomic era (eds Larsson, C., Påhlman, I.-L. & Gustafsson, L.) Chalmers Reproservice, Göteborg, pp. 345-349. Full paper.

Barer, M. R., Karelyants, A. S., Weichart, D. H., Harwood, C. R. & Kell, D. B. (1998) Microbial stress and culturability: conceptual and operational domains. Microbiology 144, 2009-2010.

Taylor, J., Rowland, J.J. & Kell, D.B. (1998) Genetic programming applied to the rapid spectroscopic analysis of biological samples. In Koza, JR (ed) Late-breaking papers at the Genetic Programming 1998 Conference, University of Wisconsin, July 22-25 1998. Omni Press, Madison.

Taylor, J., Rowland, J.J., Goodacre, R., Gilbert, R.J., Winson, M.K. & Kell, D.B. (1998) Genetic programming in the interpretation of Fourier transform infrared spectra: quantification of metabolites of pharmaceutical importance. In (Koza, J.R., Banzhaf, W., Chellapilla, K., Deb, K., Dorigo, M., Fogel, D.B., Garzon, M.H., Goldberg, D.E., Iba, H. & Riolo, R.L., eds.) Genetic Programming 1998: Proceedings of the Third Annual Conference, Madison, WI. (Morgan Kaufmann, San Francisco, CA, pub). pp. 377-380.

Gilbert, R.J., Goodacre, R., Shann, B., Taylor, J., Rowland, J.J. & Kell, D.B. (1998) Genetic programing-based variable selection for high-dimensional data. In (Koza, J.R., Banzhaf, W., Chellapilla, K., Deb, K., Dorigo, M., Fogel, D.B., Garzon, M.H., Goldberg, D.E., Iba, H. & Riolo, R.L., eds.) Genetic Programming 1998: Proceedings of the Third Annual Conference, Madison, WI. (Morgan Kaufmann, San Francisco, CA, pub.). pp. 109-115.

Oliver, S.G., Winson, M.K., Kell, D.B. & Baganz, F. (1998) Systematic functional analysis of the yeast genome. Trends Biotechnol. 16, 373-378. PMID 9744112.

Mukamolova, G.V., Kaprelyants, A.S., Young, D.I., Young, M. & Kell, D.B. (1998) A bacterial cytokine. Proc. Natl. Acad. Sci. 95, 8916-8921. PubMed abstract. Abstract at PNAS with link to pdf. Full pdf version freely available at PubMedCentral. PMID 9671779.

Woodward, A.M., Alsberg, B.K & Kell, D.B. (1998) The effect of heteroscedastic noise on the modelling of frequency domain data. Chemometr. Intell. Lab. Syst. 40, 101- 107

Alsberg, B.K., Woodward, A.M., Winson, M.K., Rowland, J.J. & Kell, D.B. (1998) Variable selection in wavelet regression models. Analytica Chimica Acta, 368, 29- 44.

Jones, A., Young, D., Taylor, J., Kell, D.B. & Rowland, J.J. (1998) Quantification of microbial productivity via multi-angle light scattering and supervised learning. Biotechnol. Bioeng., 59, 131-143. PMID 10099324.

Winson, M.K., Kaderbhai, N., Jones, A., Alsberg, B.K., Woodward, A.M., Shaw, A.D., Goodacre, R., Rowland, J.J., Kell, D.B., Todd, M. & Rudd, B.A.M. (1998) Metabolic microscopy: novel approaches to high-throughput screening in strain development and fermentation analysis using diffuse reflectance FT-IR and dispersive Raman spectroscopy with chemometrics. In (Dixon, G.K., Major, J.S. & Rice, M.J., eds) Challenges and issues in high throughput screening: a pharmaceutical and agrochemical industry perspective, pp. 151-152. SCI, London.

Kell, D.B., Kaprelyants, A.S., Weichart, D.H., Harwood, C.L. & Barer, M.R. (1998) Viability and activity in readily culturable bacteria: a review and discussion of the practical issues. Antonie van Leeuwenhoek 73, 169-187. PMID 9717575.

Goodacre, R., Timmins, É.M., Burton, R., Kaderbhai, N, Woodward, A., Kell, D.B. & Rooney, P.J. (1998) Rapid identification of urinary tract infection bacteria using hyperspectral, whole organism fingerprinting and artificial neural networks. Microbiology 144, 1157- 1170. PMID 9611790.

Goodacre, R., Rooney, P.J. & Kell, D.B. (1998) Rapid analysis of microbial systems using vibrational spectroscopy and supervised learning methods: application to the discriminatin betweenmethicillin-resistant and methicillin-susceptible Staphylococcus aureus. In Infrared Spectroscopy: New Tool in Medicine. Proc. SPIE 3257, 220-229.

Kell, D.B. & Kaprelyants, A.S. (1998) Are many microbial secondary metabolites really pheromones with important physiological functions, a knowledge of which could guide discovery programmes? Dormancy, differentiation, social resuscitation and pheromone production in nonsporulating bacteria. In Marine microorganism: research issues for biotechnology. Proc. US/EC Workshop on Marine Microorganisms, pp. 87-92. Publ. European Commission, Brussels.

Kell, D.B., Winson, M., Goodacre, R., Alsberg, B., Jones, A., Woodward, A. & Rowland, J. (1998) DRASTIC (Diffuse Reluctance Absorbance SpectroscopyTaking in Chemometrics): a rapid remote sensing method for assessing metabolite overproduction in titre improvement programmes. Global Drug Discovery: exploiting technologies to accelerate drug development, ed. Savage, L.M., publ. International Business Communications, Southborough, Mass, pp. 219-283.

Kell, D.B. & Todd, R.W. (1998) Dielectric estimation of microbial biomass using the Aber instruments biomass monitor. Trends Biotechnol. 16, 149-150.

Votyakova, T. V., Mukamolova, G. V., ShteinMargolina, V. A., Popov, V. I., Davey, H. M., Kell, D. B. & Kaprelyants, A. S. (1998) Research on the heterogeneity of a Micrococcus luteus culture during an extended stationary phase: Subpopulation separation and characterization. Microbiology (Russia) 67, 71-77.

Mukamolova GV, Yanopolskaya ND, Kell DB, Kaprelyants AS: On resuscitation from the dormant state of Micrococcus luteus. Antonie van Leeuwenhoek 1998; 73:237-243. PMID 9801768.

Taylor, J., Goodacre, R., Wade, W.G., Rowland, J.J. & Kell, D.B. (1998) The deconvolution of pyrolysis mass spectra using genetic programming: application to the identification of some Eubacterium species. FEMS Microbiology Letters 160, 237- 246. PMID 9532743.

Jones, A., Shaw, A.D., Salter, G.J., Bianchi, G. & Kell, D.B. (1998) The exploitation of chemometric methods in the analysis of spectroscopic data: application to olive oils. in Lipid Analysis of Oils and Fats (ed. R.J. Hamilton), publ. Chapman & Hall, pp 317-376.

Goodacre, R., Rooney, P.J. & Kell, D.B. (1998) Discrimination between susceptible and methicillin-resistant Staphylococcus aureus using pyrolysis mass spectrometry and artificial neural networks. J. Antimicrobial Chemotherapy 41, 27-34. PMID 9511034.

Winson, M. K., Todd, M., Rudd, B. A. M., Jones, A., Alsberg, B. K., Woodward, A. M., Goodacre, R., Rowland, J. J. & Kell, D. B. (1998) A DRASTIC (Diffuse Reflectance Absorbance Spectroscopy Taking in Chemometrics) approach for the rapid analysis of microbial fermentation products: quantification of aristeromycin and neplanocin A in Streptomyces citricolor broths. New frontiers in screening for microbial biocatalysts (Kieslich, K., van der Beek, C.P., de Bont, J.A.M. & van den Tweel, W.J.J., eds), pp. 185-191. Elsevier, Amsterdam.

Kell, D.B., Winson, M.K., Goodacre, R., Woodward, A.M., Alsberg, B.K., Jones, A., Timmins, É and Rowland, J.J. (1998) DRASTIC (Diffuse Reflectance Absorbance Spectroscopy Taking In Chemometrics). A novel, rapid, hyperspectral, FT-IR-based approach to screening for biocatalytic activity and metabolite overproduction. In New frontiers in screening for microbial biocatalysts (Kieslich, K., van der Beek, C.P., de Bont, J.A.M. & van den Tweel, W.J.J., eds), Stud Org Chem 53, 61-75. Elsevier, Amsterdam.

Gilbert, R.J., Goodacre, R., Woodward, A.M. & Kell, D.B. (1997) Genetic programming: a novel method for the quantitative analysis of pyrolysis mass spectral data. Anal. Chem. 69, 4381-4389. PMID 21639171.

Goodacre, R., Timmins, É.M., Jones, A., Kell, D.B., Maddock, J., Heginbothom, M.L. and Magee, J.T. (1997) On mass spectrometer instrument standardization and interlaboratory calibration transfer using neural networks. Anal. Chim. Acta 348, 511-532.

Alsberg, B.K., Goodacre, R., Rowland, J.J. & Kell, D.B. (1997) Classification of pyrolysis mass spectra by fuzzy multivariate rule induction; comparison with regression, K- nearest neighbour, neural and decision-tree methods. Anal. Chim. Acta 348, 389-407.

Shaw, A.D., di Camillo, A., Vlahov, G., Jones, A., Bianchi, G., Rowland, J. & Kell, D.B. (1997) Discrimination of the variety and region of origin of extra virgin olive oils using ¹³C NMR and multivariate calibration with variable reduction. Anal. Chim. Acta 348, 357-374.

Winson, M.K., Goodacre, R., Timmins, É., Jones, A., Alsberg, B.K., Woodward, A.M., Rowland, J.J. & Kell, D.B. (1997) Diffuse Reflectance Absorbance Spectroscopy Taking In Chemometrics (DRASTIC). A hyperspectral FT-IR-based approach to rapid screening for metabolite overproduction. Anal. Chim. Acta 348, 273-282.

Broadhurst, D., Goodacre, R., Jones, A., Rowland, J.J. & Kell, D.B. (1997) Genetic algorithms as a method for variable selection in PLS regression, with applications to pyrolysis mass spectrometry. Anal. Chim. Acta 348, 71-86.

Tidswell, E.C., Salter, G.J., Kell, D.B. & Morris, J.G. (1997) Enantioselectivity of sulcatone reduction by some anaerobic bacteria. Enz. Micr. Technol. 21, 143-147.

Kell, D.B. (1997) Target practice – novel approaches to antimicrobial chemotherapy [meeting report]. Trends Biotechnol. 15, 334-336.

Davey, H.M. & Kell, D.B. (1997) Fluorescent brighteners: novel stains for the flow cytometric analysis of microorganisms. Cytometry 28, 311-315. PMID 9266751.

Davey, C.L., Guan, Y., Kemp, R.B. & Kell, D.B. (1997) Real-time monitoring of the biomass content of animal cell cultures using dielectric spectroscopy. In Animal cell technology: basic and applied aspects, Vol 8, ed. K. Funatsu, Y. Shirai & T. Matsushita, pp. 61-65, publ. Kluwer, Dordrecht.

Alsberg, B.K., Woodward, A.M. & Kell, D.B. (1997) An introduction to wavelet transforms for chemometricians: a time-frequency approach. Chemometrics and Intelligent Laboratory Systems 37, 215-239.

Salter G.J., Lazzari M., Giansante L., Goodacre R., Jones, A., Surricchio G., Kell D.B. and Bianchi G. (1997) Determination of the geographical origin of Italian extra virgin olive oil using pyrolysis mass spectrometry and artificial neural networks. J. Anal. Appl. Pyrol. 40/41, 159-170.

Goodacre, R., Hammond, D. & Kell, D.B. (1997) Quantitative analysis of the adulteration of orange juice with sucrose using pyrolysis mass spectrometry and chemometrics. J. Anal. Appl. Pyrol. 40/41, 135-158.

Alsberg, B.K., Woodward, A.M., Winson, M.K., Rowland, J.J. and Kell, D.B. (1997) Wavelet denoising of infrared spectra. Analyst 122, 645-652.

Alsberg, B.K., Winson, M.K. & Kell, D.B. (1997) Improving interpretation of multivariate and rule induction models by using a spectral peak parameter representation. Chemometrics and Intelligent Laboratory Systems, 36, 95-109.

Winson, M.K. & Kell, D.B. (1997) If you’ve got it, flaunt it – rapid screening for microbial biocatalysts [meeting report] Trends Biotechnol. 15, 120-122. PMID 9131832.

Mendes, P. & Kell, D.B. (1997) Making cells work – metabolic engineering for everyone. [meeting report] Trends Biotechnol. 15, 6-7.

Davey, H.M. & Kell, D.B. (1996) Flow cytometry and cell sorting of heterogeneous microbial populations: the importance of single-cell analyses. Microbiol. Rev. 60, 641-696. PMID 8987359.

Westerhoff, H.V. & Kell, D.B. (1996) What BioTechnologists knew all along…? J. Theoret. Biol. 182, 411-420. PMID 8944175.

Woodward, A.M., Jones, A., Zhang, X.-Z., Rowland, J. & Kell, D.B. (1996) Rapid and non-invasive quantification of metabolic substrates in biological cell suspensions using nonlinear dielectric spectroscopy with multivariate calibration and artificial neural networks. Principles and applications. Bioelectrochem. Bioenerg. 40, 99-132.

Goodacre, R., Neal, M.J. & Kell, D.B. (1996) Quantitative analysis of multivariate data using artificial neural networks: a tutorial review and applications to the deconvolution of pyrolysis mass spectra. Zentralblatt. für Bakteriologie 284, 516-539. PMID 8899971.

Kell, D.B., Goodacre, R. & Neal, M.J. (1996) Rapid analysis of multiple determinands using pyrolysis mass spectrometry and supervised learning with artificial neural networks. In (Berg, D.A., ed.) Proc. 1994 ERDEC Scientific Conference on chemical and biological defense research, pp 53-59. ERDEC-SP-036, Aberdeen Proving Ground.

Mendes, P. & Kell, D.B. (1996) Biothermokinetics, metabolic control analysis, metabolic engineering and the World Wide Web: rapid dissemination over the Internet. In Westerhoff H.V., Snoep J.L., Sluse F.E., Wijker J.E. and Kholodenko B.N. (eds.) BioThermoKinetics of the Living Cell, pp. 254-257, BioThermoKinetics Press, Amsterdam.

Mendes, P. & Kell, D.B. (1996) Computer simulation of biochemical kinetics. In Westerhoff H.V., Snoep J.L., Sluse F.E., Wijker J.E. and Kholodenko B.N. (eds.) BioThermoKinetics of the Living Cell, pp. 245-251, BioThermoKinetics Press, Amsterdam.

Goodacre, R., Pygall, J. & Kell, D.B. (1996) Plant seed classification using pyrolysis mass spectrometry with unsupervised learning; the application of auto-associative and Kohonen artificial neural networks. Chemometr. Intell. Lab. Syst., 34, 69-83.

Winson, M.K. & Kell, D.B. (1996) Going places: forced and natural molecular evolution (Meeting report). Trends Biotechnol. 14, 323-325. PMID 8818282.

Goodacre, R., Timmins, É.M., Rooney, P.J., Rowland, J.J. & Kell, D.B. (1996) Rapid identification of Streptococcus species using diffuse reflectance-absorbance Fourier transform infrared spectroscopy and artificial neural networks. FEMS Microbiol. Lett. 140, 233-239. PMID 8764485. Most cited paper of 1996 in that journal.

Davey, H.M., Davey, C.L., Woodward, A.M., Edmonds, A.N., Lee, A.W. & Kell, D.B. (1996) Oscillatory, stochastic and chaotic growth rate fluctuations in permittistatically- controlled yeast cultures. Biosystems 39, 43-61. PMID 8735387.

Kell, D.B. (1996) Membrane tension (letter). Trends Cell Biol. .6, 171. PMID 15157466.

Kaprelyants, A.S. & Kell, D.B. (1996) Do bacteria need to communicate with each other for growth? Trends Microbiol. 4, 237-242. PMID 8795160.

Kaprelyants, A.S., Mukamolova, G.V., Davey, H.M. & Kell, D.B. (1996) Quantitative analysis of the physiological heterogeneity within starved cultures of Micrococcus luteus using flow cytometry and cell sorting. Appl. Env. Microbiol. 62, 1311-1316. PMID 16535295.

Nicholson, D.J., Kell, D.B. & Davey, C.L. (1996) Deconvolution of the dielectric spectra of microbial cell suspensions using multivariate calibration and artificial neural networks. Bioelectrochem. Bioenerg. 39, 185-193.

Goodacre, R. & Kell, D.B. (1996) Neural network analyses of pyrolysis mass spectral data: applications to the assessment of food adulteration, monitoring fermentor broths, and the correction of mass spectral drift. Proceedings of MolMass 96 – 2nd International Conference on Molecular Mass Characterization of Synthetic and Natural Polymers, 1-4 April, 1996. 7 pp

Mendes, P., Kell, D.B. & Westerhoff, H.V. (1996) Why and when channelling can decrease pool size at constant net flux in a simple dynamic channel. Biochim. Biophys. Acta 1289, 175-186. PMID 8600971.

Mendes, P. & Kell, D.B. (1996) On the analysis of the inverse problem of metabolic pathways using artificial neural networks. Biosystems 38, 15-28. PMID 8833745.

Goodacre, R. & Kell, D.B. (1996) Pyrolysis mass spectrometry and its applications in biotechnology. Curr. Opinion Biotechnol. 7, 20-28. PMID 8791308.

Goodacre, R. & Kell, D.B. (1996) Correction of mass spectral drift using artificial neural networks. Anal. Chem. 68, 271-280. PMID 9027237.

Davey, C.L. & Kell, D.B. (1995) The low-frequency dielectric properties of biological cells. In (D. Walz, H. Berg & G. Milazzo, eds) Bioelectrochemistry of cells and tissues, pp. 159-207, Birkhäuser, Zürich.

Kell, D.B. & Sonnleitner, B. (1995) GMP – Good Modelling Practice: an essential component of good manufacturing practice. Trends Biotechnol., 13, 481-492.

Goodacre, R., Trew, S., Wrigley-Jones, C., Saunders, G., Neal, M.J., Porter, N. & Kell, D.B. (1995) Rapid and quantitative analysis of metabolites in fermentor broths using pyrolysis mass spectrometry with supervised learning: application to the screening of Penicillium chryosgenum fermentations for the overproduction of penicillins. Anal. Chim. Acta 313, 25-43.

Salter, G.J. and Kell, D.B. (1995) Solvent selection for whole cell biotransformations in organic media. CRC Crit Rev. Biotechnol. 15, 139-177. PMID 7641292.

Mendes, P., Kell, D.B. & Westerhoff, H.V. (1995) A series of cases in which metabolic channeling can decrease the pool size at constant net flux in a simple dynamic channel. Biochem. Soc. Trans. 23, S 287. PMID 7672313.

Woodward, A.M. & Kell, D.B. (1995) On harmonic generation in nonlinear biological systems. Biosensors Bioelectronics 10, 639-641. PMID 7612211.

Goodacre, R., Biamchi, G. & Kell, D.B. (1995) Food adulteration exposed by neural networks. Analysis Europa, June issue, pp. 35-37.

Mukamolova G.V., Yanopolskaya N.D., Votyakova T.V., Popov V.I., Kaprelyants A.S. & Kell D.B. (1995) Biochemical changes accompanying the long-term starvation of Micrococcus luteus cells in spent growth medium. Arch. Microbiol. 163, 373-379.

Mendes, P., Kell, D.B. & Welch, G.R. (1995) Metabolic channeling in organized enzyme systems: experiments and models. In: Enzymology in vivo (Adv. Mol. Cell. Biol. 11, 1-19) (ed. K. Brindle), JAI Press, London. Manuscript in pdf .

Mukamolova, G.V., Kaprelyants, A.S. & Kell, D.B. (1995) Secretion of an antibacterial factor during resuscitation of dormant cells in Micrococcus luteus cultures held in an extended stationary phase. Antonie van Leeuwenhoek, 67, 289-295. PMID 7778897.

Markx, G.H. & Kell, D.B. (1995) The use of dielectric permittivity for the control of the biomass level during biotransformations of toxic substrates in continuous culture. Biotechnology Progress, 11, 64-70. PMID 7765989.

Kell, D.B., Kaprelyants, A.S. & Grafen, A. (1995) On pheromones, social behaviour and the functions of secondary metabolism in bacteria. Trends Ecol. Evolution 10, 126- 129. PMID 21236981.

Tatebe, W., Woodward, A.M. & Kell, D.B. (1994) Nonlinear dielectric properties and their relationship to the physiological state (resting or active) of Saccharomyces cerevisiae. Mem. Fac. Eng. Osaka City Univ. 35, 53-57.

Goodacre, R., Trew, S., Wrigley-Jones, C., Neal, M.J., Maddock, J., Ottley, T.W., Porter, N. & Kell, D.B. (1994) Rapid screening for metabolite overproduction in fermentor broths, using pyrolysis mass spectrometry with multivariate calibration and artificial neural networks. Biotechnol. Bioeng. 44, 1205-1216. PMID 18618547.

Kell, D.B., Goodacre, R. & Neal, M.J. (1994) The dogs that did not bark. Trends Biotechnol. 12, 494-495 (refereed letter). PMID 7765540.

Mendes, P. & Kell, D.B. (1994) Simultaneous estimates of single-enzyme kinetic parameters for multi-enzymatic systems using artificial neural networks. in What is controlling life? 50 years after Schrödinger’s What is Life? (E. Gnaiger, F.N. Gellerich & M. Wyss, eds) Modern Trends in Biothermokinetics Vol 3, 302-304. Innsbruck University Press, Innsbruck.

Kell, D.B., Davey, H.M., Mukamolova, G.V., Votyakova, T.V. & Kaprelyants, A.S. (1994) Life, death, dormancy and social resuscitation in non-sporulating bacteria: relationships with the energetic status of individual cells. in What is controlling life? 50 years after Schrödinger’s What is Life? (E. Gnaiger, F.N. Gellerich & M. Wyss, eds) Modern Trends in Biothermokinetics Vol 3, 252-254. Innsbruck University Press, Innsbruck.

Mendes, P, Kell, D.B. & Westerhoff, H.V. (1994) How to vary the proportion of dynamic channelling flux at constant total flux (and decrease the intermediate pool size…). in What is controlling life? 50 years after Schrödinger’s What is Life? (E. Gnaiger, F.N. Gellerich & M. Wyss, eds) Modern Trends in Biothermokinetics Vol 3, 202-204. Innsbruck University Press, Innsbruck.

Beving, H., Eriksson, L.E.G., Davey, C.L. & Kell, D.B. (1994) Dielectric properties of human erythrocytes and blood at radio frequencies (0.2 – 10 MHz); dependence on cell volume fraction and medium composition. Eur. Biophys. J. 23, 207-215. PMID 7956980.

Votyakova, T.V., Kaprelyants, A.S. & Kell, D.B. (1994) Influence of viable cells on the resuscitation of dormant cells in Micrococcus luteus cultures held in extended stationary phase. The population effect. Appl. Env. Microbiol. 60, 3284-3291. PMID 16349381.

Kell, D.B. & Woodward, A.M. (1994) The nonlinear dielectric properties of biological systems: a set of methods for assessing the behaviour of enzymes in situ. In (H.V. Westerhoff, ed.) Biothermokinetics. Intercept Press, London, pp 431-434.

Neal, M.J., Goodacre, R. & Kell, D.B. (1994) On the analysis of pyrolysis mass spectra using artificial neural networks. Individual input scaling leads to rapid learning. Proceedings of the World Congress on Neural Networks 1994, San Diego, I-318 – I-323.

Goodacre, R., Karim, A., Kaderbhai, M. & Kell, D.B. (1994) Rapid and quantitative analysis of recombinant protein expression using pyrolysis mass spectrometry and artificial neural networks: application to mammalian cytochrome b₅ in Escherichia coli. J. Biotechnol., 34, 185-193. PMID 7764850.

Goodacre, R., Neal, M.J. & Kell, D.B. (1994) Rapid and quantitative deconvolution of the pyrolysis mass spectra of complex binary and tertiary mixtures using multivariate calibration and artificial neural networks. Anal. Chem., 66, 1070-1085.

Kell, D.B. (1994) Between the bud and the rose [book review]. Trends Biochem. Sci. 19, 184.

Kaprelyants, A.S., Mukamolova, G.V. & Kell, D.B. (1994) Estimation of dormant Micrococcus luteus cells by penicillin lysis and by resuscitation in cell-free spent culture medium at high dilution. FEMS Microbiol. Lett., 115, 347-352.

Mendes, P. & Kell, D.B. (1993) Control analysis of metabolic channelling. Modern Trends in Biothermokinetics, eds S. Schuster, M. Rigoulet, R. Ouhabi & J.-P. Mazat, Plenum Press, New York and London, 211-216.

Kell, D.B., Davey, C.L., Goodacre, R. & Sauro, H.M. (1993) When going backwards means progress: on the solution of biochemical inverse problems using artificial neural networks. Modern Trends in Biothermokinetics, eds S. Schuster, M. Rigoulet, R. Ouhabi & J.-P. Mazat, Plenum Press, New York and London, 109-114.

Goodacre, R., Kell, D.B. & Bianchi, G. (1993) Rapid assessment using pyrolysis mass spectrometry and artificial neural networks of the adulteration of virgin olive oils by other seed oils. J. Sci. Food Agric. 63, 297-307.

Davey, H.M., Davey, C.L. & Kell, D.B. (1993) SKATGRAF: a stand-alone program for the calibration and plotting of flow cytometric data. Binary 5, 165-170.

Mendes, P. & Kell, D.B. (1993) On the role of enzyme kinetic parameters in determining the effectiveness with which channelling can decrease the size of a metabolite pool. Acta Biotheoretica 41, 63-73. PMID 8266746.

Kaprelyants, A.S. & Kell, D.B. (1993) Dormancy in stationary-phase cultures of Micrococcus luteus: flow cytometric analysis of starvation and resuscitation. Appl. Env. Microbiol. 59, 3187-3196. PMID 16349059.

Goodacre, R. Edmonds, A.N. & Kell, D.B. (1993) Quantitative analysis of the pyrolysis mass spectra of complex mixtures using artificial neural networks: application to amino acids in glycogen. J. Anal. Appl. Pyrol. 26, 93-114.

Davey, C.L., Markx, G.H. & Kell, D.B. (1993) On the dielectric method of monitoring cellular viability. Pure Appl. Chem. 65, 1921-1926.

Davey, C.L., Davey, H.M., Kell, D.B. & Todd, R.W. (1993) An introduction to the dielectric estimation of cellular biomass in real time, with special emphasis on measurements at high volume fractions. Anal. Chim. Acta 279, 155-161.

Goodacre, R. & Kell, D.B. (1993) Rapid analysis of bioprocesses using pyrolysis mass spectrometry and neural networks: application to indole production. Anal. Chim. Acta 279, 17-26.

Goodacre, R., Kell, D.B. & Bianchi, G. (1993) Olive oil quality control by using pyrolysis mass spectrometry and artificial neural networks. Olivæ 47, 36-38.

Goodacre, R., Kell, D.B. & Bianchi, G. (1993) Rapid assessment of food adulteration using pyrolysis mass spectrometry and neural networks: application to extra virgin olive oils. Central Office of Information Newsletter.

Kaprelyants, A.S., Gottschal, J.C. & Kell, D.B. (1993) Dormancy in nonsporulating bacteria. FEMS Microbiol. Rev. 104, 271-286. PMID 8318260.

Kell, D.B., Westerhoff, H.V., Fell, D., Thomas, S. & Mendes, P. (1993) Demonstration programs illustrating the modelling of metabolic systems [meeting report], Binary 5, 47-49.

Davey, H.M., Kaprelyants, A.S. & Kell, D.B. (1993) Flow cytometric analysis, using rhodamine 123, of Micrococcus luteus at low growth rate in chemostat culture. In Flow cytometry in microbiology, ed. D. Lloyd, Springer-Verlag, Heidelberg, pp. 83- 93.

Davey, H.M., Davey, C.L. & Kell, D.B. (1993) On the determination of the size of microbial cells using flow cytometry. In Flow cytometry in microbiology, ed. D. Lloyd, Springer-Verlag, Heidelberg, pp. 49-65.

Kaprelyants, A.S. & Kell, D.B. (1993) The use of 5-cyano-2,3-ditolyl tetrazolium chloride and flow cytometry for the visualisation of respiratory activity in individual cells of Micrococcus luteus. J. Microbiol. Methods. 17, 115-122.

McShea, A., Woodward, A.M. & Kell, D.B. (1992) Non-linear dielectric properties of Rhodobacter capsulatus. Bioelectrochem. Bioenerg. 29, 205-214.

Salter, G.J. & Kell, D.B. (1992) Rapid determination, using dielectric spectroscopy, of the toxicity of organic solvents to intact cells. In Fundamentals of biocatalysis in non- conventional media, ed. J. Tramper, M.H. Vermüe, H.H. Beeftink & U. von Stockar, pp. 291-297. Elsevier, Amsterdam.

Goodacre, R., Kell, D.B. & Bianchi, G. (1992) Neural networks and olive oil. Nature 359, 594.

Kell, D.B. & Davey, C.L. (1992) On fitting dielectric spectra using artificial neural networks. Bioelectrochem. Bioenerg. 28, 425-434.

Davey, C.L., Davey, H.M. & Kell, D.B. (1992) On the dielectric properties of cell suspensions at high volume fractions. Bioelectrochem. Bioenerg. 28, 319-340.

Peñaloza, W., Davey, C.L., Hedger, J.N. & Kell, D.B. (1992) Physiological studies on the quinoa tempe fermentation, using on-line measurements of fungal biomass production. J. Sci. Food Agric., 59, 227-235.

Salter, G.J. & Kell, D.B. (1992) New materials and technology for cell immobilisation. Curr Opin Biotechnol 3, 115-118. PMID 1368285.

Kell, D.B. (1992) Biophysics for the next century, in G. Arcidiacono, U. Bartocci & M. Mamone Capria (eds.) What physics for the next century?, p. 17. Società Editrice Andromeda, Bologna.

Kell, D.B. (1992) The protonmotive force as an intermediate in electron transport-linked phosphorylation: problems and prospects. Curr. Top. Cell. Reg., 33, 279-289. PMID 1323445.

Kell, D.B. (1992) “Scanning Tunnelling Microscopy” in biology; are the current carriers tunnelling electrons or hydrated protons? Bioelectrochem. Bioenerg., 27, 235-237.

Kaprelyants, A.S. & Kell, D.B. (1992) Rapid assessment of bacterial viability and vitality using rhodamine 123 and flow cytometry. J. Appl. Bacteriol., 72, 410-422.

Kell, D.B., Davey, C.L. & Todd, R.W. (1992) Real-time measurement of cellular biomass using dielectric spectroscopy. In. Biotechnology International, 2nd Edition (R.N. Greenshields, ed), pp. 294-297, publ. Grosvenor Press, London.

Kell, D.B. & Woodward, A.M. (1992) Analysis of biological material by a nonlinear dielectric spectrum. UK Patent 2 247 530 (granted 4.5.94).

Mendes, P., Kell, D.B. & Westerhoff, H.V. (1992) Channelling can decrease pool size. Eur. J. Biochem., 204, 257-266. PMID 1740137.

Kell, D.B., Ryder, H.M., Kaprelyants, A.S. & Westerhoff, H.V. (1991) Quantifying heterogeneity: flow cytometry of bacterial cultures. Antonie van Leeuwenhoek 60, 145-158. PMID 1725477.

Woodward, A.M. & Kell, D.B. (1991) On the relationship between the nonlinear dielectric properties and respiratory activity of the obligately aerobic bacterium Micrococcus luteus. Bioelectrochem. Bioenerg. 26, 423-439.

Woodward, A.M. & Kell, D.B. (1991) Confirmation by using mutant strains that the membrane-bound H⁺-ATPase is the major source of nonlinear dielectricity in Saccharomyces cerevisiae. FEMS Microbiol. Lett., 84, 91-96. PMID 1837530.

Kell, D.B. & Woodward, A.M. (1991) Nonfaradaic electrochemical sensors: principles and practice. Anal. Proc., 28, 378-379.

Markx, G.H., Davey, C.L., Kell, D.B. & Morris, P. (1991) The dielectric permittivity at radio frequencies and the Bruggeman probe: novel techniques for the on-line determination of biomass concentrations in plant cell cultures. J. Biotechnol. 20, 279-290.

Kell, D.B. (1991) On the physiological significance of metabolic channelling; if, how and when, but not why. J. Theoret. Biol., 152, 49-51. PMID 1753766.

Kell, D.B. & Welch, G.R. (1991) No turning back: reductionism and biological complexity. Times Higher Educational Supplement, 9th August, p. 15. pdf of manuscript.

Woodward, A.M. & Kell, D.B. (1991) Dual-frequency excitation: a novel method for probing the nonlinear dielectric properties of biological systems, and its application to suspensions of S. cerevisiae. Bioelectrochem. Bioenerg., 25, 395-413.

Kell, D.B. (1991) Bioinstrumentation: research, development and applications [book review]. SGM Quarterly 18, 67.

Salter, G.J. & Kell, D.B. (1991) New materials and technology for cell immobilisation. Curr Opin Biotechnol 2, 385-389. PMID 1367826.

Kell, D.B. (1991) Paying for the privilege. [Technology Transfer in Japan and the UK] Times Higher Educational Supplement, June 26, p. VI.

Markx, G.H., Davey, C.L. & Kell, D.B. (1991) To what extent is the value of the Cole-Cole a of the β-dielectric dispersion of cell suspensions accountable in terms of the cell size distribution? Bioelectrochem. Bioenerg. 25, 195-211.

Peñaloza, W., Davey, C.L., Hedger, J.N. & Kell, D.B. (1991) Stimulation by potassium of the growth of Rhizopus oligosporus during liquid- and solid-substrate fermentations. World J. Microbiol. Biotechnol, 7, 260-268. PMID 24424941.

Davey, C.L., Peñaloza, W., Kell, D.B. & Hedger, J.N. (1991) Real- time monitoring of the accretion of Rhizopus oligosporus biomass during the solid-substrate tempe fermentation. World J. Microbiol. Biotechnol, 7, 248-259. PMID 24424940.

Kell, D.B. (1991) Lacuna seeker [letter]. Nature 350, 268.

Kell, D.B. (1991) Biosensor Technology: Fundamentals and Applications. : R.P. Buck, E.F. Bowden, M. Umaña and W.E. Hatfield (Editors). Marcel Dekker, New York, 1990[BOOK REVIEW]

Markx, G.H., Davey, C.L. & Kell, D.B. (1991) The permittistat: a novel type of turbidostat. J. Gen. Microbiol., 137, 735-743.

Woodward, A.M. & Kell, D.B. (1990) On the nonlinear dielectric properties of biological systems. Saccharomyces cerevisiae. Bioelectrochem. Bioenerg., 24, 83- 100.

Markx, G.H. & Kell D.B. (1990) Dielectric spectroscopy as a tool for the measurement of the formation of biofilms and of their removal by electrolytic cleaning pulses and biocides. Biofouling, 2, 211-227.

Davey, C.L., Kell, D.B. & Dixon, N.M. (1990) SKATFIT: A program for determining the mode of growth of individual microbial cells from flow cytometric data. Binary, 2, 127-132.

Davey, C.L., Dixon, N.M. & Kell, D.B. (1990) FLOWTOVP: a spreadsheet method for linearising flow cytometric light-scattering data used in cell sizing. Binary, 2, 119-125.

James, E.W., Dixon, N.M., Denholm, A.M., Kell, D.B. & Morris, J.G. (1990) Electromicrobial and related approaches to anaerobic biotransformations. In: Opportunities in Biotransformations (L.G. Copping, R.E. Martin, J.A. Pickett, C. Bucke & A.W. Bunch, eds.), pp. 195-202. Elsevier Applied Science, London.

Kell, D.B. & Davey, C.L. (1990) Conductimetric and Impedimetric Devices. In: Biosensors: a practical approach (A.E.G. Cass, ed.), IRL Press, Oxford, pp. 125- 154.

Ferris, L.E., Davey, C.L. & Kell, D.B. (1990) Evidence from its temperature- dependence that the β-dielectric dispersion of cell suspensions is not due solely to the charging of a static membrane capacitance. Eur. Biophys. J., 18, 267-276.

Davey, C.L., Markx, G.H. & Kell, D.B. (1990) Substitution and spreadsheet methods for analysing dielectric spectra of biological systems. Eur. Biophys. J., 18, 255-265.

Kell, D.B. & Westerhoff, H.V. (1990) Metabolic control analysis: theory and practice. In: Mixed and multiple substrates and feedstocks, ed. G. Hamer, T. Egli & M. Snozzi, pp.107-119, Hartung-Gorre, Konstanz.

Kell, D.B., Markx, G.H., Davey, C.L. & Todd, R.W. (1990) Real-time monitoring of cellular biomass: methods and applications. Trends Anal. Chem., 9, 190-194.

Salter, G.J., Kell, D.B., Ash, L.A., Adams, J.M., Brown, A.J. & James, R. (1990) Hydrodynamic deposition: a novel method of cell immobilisation. Enz. Micr. Technol., 12, 419-430. PMID 1366629.

Markx, G.H., Davey, C.L., Todd, R.W. & Kell, D.B. (1990) The real time measurement of biomass accretion using dielectric spectroscopy. In: Practical advances in fermentation technology, Institution of Chemical Engineers, North Western Branch, Symposium Papers No 3, pp. 5.1-5.9.

Davey, C.L. & Kell, D.B. (1990) The dielectric properties of cells and tissues: what can they tell us about cellular physiology and the mechanisms of field/cell interactions? In: Emerging Electromagnetic Medicine (ed. M.E. O’Connor, R.H.C. Bentall & J.C. Monahan). Springer-Verlag, New York., pp. 19-43.

Kell, D.B. & Westerhoff, H.V. (1990) Control analysis of organised multienzyme systems. In: Structural and organizational aspects of metabolic regulation, UCLA Symposia on Molecular and Cellular Biology, New Series, Vol 133 (P. Srere, M.E. Jones & C. Mathews, eds), pp. 273-289. Alan R. Liss, New York.

Walter, R.P., Kell, D.B., Morris, J.G., James, R. & Adams, J.M. (1989) Catalytic activity of Candida cylindracea lipase immobilised on ceramic supports. Biotechnol. Tech., 3, 345-348.

Stoicheva, N., Davey, C.L., Markx, G.H. & Kell, D.B. (1989) Dielectric spectroscopy: a rapid method for the determination of solvent biocompatibility during biotransformations. Biocatalysis 2, 245-255.

Dixon, N.M. & Kell, D.B. (1989) The inhibition by CO₂ of the growth and metabolism of microorganisms. J. Appl. Bacteriol., 67, 109-136. PMID 2509409.

Dixon, N.M., James, E.W., Lovitt, R.W. & Kell, D.B. (1989) Electromicrobial transformations using the pyruvate synthase system of Clostridium sporogenes. Bioelectrochem. Bioenerg. 21, 245-259.

Kell, D.B. (1989) Biosensors [book review] Bioelectrochem. Bioenerg. 21, 110-111.

Kell, D.B. (1989) Window boxes? [letter] Nature 338, 612.

Kell, D.B. & Todd, R.W. (1989) Determination of Biomass. US Patent # 4,810,650 of March 7th.

Davey, C.L. & Kell, D.B. (1989) Low-frequency dielectric properties of cell suspensions. In: Electric Field Phenomena in Biological Systems (R. Paris, ed.) Institute of Physics Short Meetings 21, 51-63. IOP Publishing, Bristol.

Kell, D.B., van Dam, K. & Westerhoff, H.V. (1989) Control analysis of microbial growth and productivity. Symp. Soc. Gen. Microbiol. 44, 61-93.

Westerhoff, H.V., Astumian, R.D. & Kell, D.B. (1988) Mechanisms for the interaction between nonstationary electric fields and biological systems. II. Nonlinear dielectric theory and free-energy transduction. Ferroelectrics 86, 79-101.

Kell, D.B., Astumian, R.D. & Westerhoff, H.V. (1988) Mechanisms for the interaction between nonstationary electric fields and biological systems. I. Linear dielectric theory and its limitations. Ferroelectrics 86, 59-78.

Davey, C.L., Kemp, R.B., Meredith, R.W.J. & Kell, D.B. (1988) On the audio- and radio-frequency dielectric behaviour of anchorage-independent, mouse L929-derived LS fibroblasts. Bioelectrochem. Bioenerg. 20, 83-98.

James, E.W., Kell, D.B., Lovitt, R.W. & Morris, J.G. (1988) Electrosynthesis and electroanalysis using Clostridium sporogenes. Bioelectrochem. Bioenerg. 20, 21- 32.

Kell, D.B. (1988) Biosensors: fundamentals and applications [book review]. Bioelectrochem. Bioenerg. 19, 589.

Dixon, N.M., Lovitt, R.W., Morris, J.G. & Kell, D.B. (1988) Growth energetics of Clostridium sporogenes NCIB 8053: modulation by CO₂. J. Appl. Bacteriol. 65, 119-134.

Kell, D.B. (1988) Protonmotive energy-transducing systems: some physical principles and experimental approaches. In: Bacterial Energy Transduction (C.J. Anthony, ed.), pp. 429-490. Academic Press, London.

Westerhoff, H.V., Kell, D.B. & Astumian, R.D. (1988) The dynamics of electrostatic interactions between membrane proteins. J. Electrostatics 21, 257-298.

Kell, D.B. (1988) Electronic measurement of cellular biomass. Trends Biotechnol. 6, 268-269.

Adams, J.M., Ash, L.A., Brown, A.J., James, R., Kell, D.B., Salter G.J. & Walter, R.P. (1988) A range of ceramic biosupports. Int. Biotechnol. Lab. 6 (3), 22-27.

Kell, D.B. (1988) A theoretical treatise [Book Review]. Trends Biochem. Sci. 13, 406.

Pugh, S.Y.R., James, E.W., Kell, D.B. & Morris, J.G. (1988) Biotransformations Club Report: Cofactor recycling during biotransformations, 35pp. Laboratory of the Government Chemist.

Kell, D.B. (1988) Coherent properties of energy-coupling membrane systems. In: Biological Coherence and Response to External Stimuli (H. Fröhlich, ed.). Springer, Heidelberg, pp. 233-241.

Westerhoff, H.V. & Kell, D.B. (1988) A control theoretical analysis of inhibitor titrations of metabolic channelling. Comments Mol. Cell. Biophys. 5, 57-107.

Kell, D.B. (1988) Dielectric Spectroscopy of Biological Systems. In: ISI Atlas of Science: Biochemistry. Vol 1, 25-29. Institute for Scientific Information, Philadelphia.

Lovitt, R.W., James, E.W., Kell, D.B. & Morris, J.G. (1987) Bioelectrochemical transformations catalysed by Clostridium sporogenes, In: Bioreactors and Biotransformations (G.W. Moody & P.B. Baker, eds) pp.263-276. Elsevier Applied Science Publishers, London.

Dixon, N.M., Lovitt, R.W., Kell, D.B. & Morris, J.G. (1987) Effects of pCO₂ on the growth and metabolism of Clostridium sporogenes NCIB 8053 in defined media. J. Appl. Bacteriol. 63, 171-182.

Kell, D.B. (1987) Non-thermally excited modes and free energy transduction in proteins and biological membranes. In: Energy Transfer Dynamics (T.W. Barrett & H.A. Pohl, eds), pp. 237-246. Springer, Heidelberg.

Kell, D.B. (1987) Forces, fluxes and the control of microbial growth and metabolism. The twelfth Fleming lecture. J. Gen. Microbiol. 133, 1651-1665.

Westerhoff, H.V. & Kell, D.B. (1987) Matrix method for determining the steps most rate-limiting to metabolic fluxes in biotechnological processes. Biotechnol. Bioeng. 30, 101- 107. Selected as a Vintage Paper in Nielsen, J. (2009) Vintage Paper: Quantification of Flux Control in Metabolic Pathways. Biotechnol. Bioeng. 104, No.1, 3-9. PMID 18576589.

Pethig, R. & Kell, D.B. (1987) The passive electrical properties of biological systems: their role in physiology, biophysics and biotechnology. Phys. Med. Biol. 32, 933-970. PMID 3306721.

Kell, D.B., Samworth, C.M., Todd, R.W., Bungard, S.J. & Morris, J.G. (1987) Real-time estimation of microbial biomass during fermentations, using a dielectric probe. Studia Biophys. 119, 153-156.

Kell, D.B. (1987) The principles and potential of electrical admittance spectroscopy: an introduction. In: Biosensors; fundamentals and applications (A.P.F.Turner, I.Karube & G.S. Wilson, eds.), pp. 427-468. Oxford University Press.

Kell, D.B. (1987) Bioelectrochemical phenomena: their role and exploitation in science and technology. University of Wales Rev. Sci. Technol. 1, 64-71.

Walter, R.P., Kell, D.B. & Morris, J.G. (1987) The roles of osmotic stress and water activity in the inhibition of the growth, glycolysis and glucose phosphotransferase system of Clostridium pasteurianum. J. Gen. Microbiol. 133, 259-266. PMID 2821163.

Lovitt, R.W., Kell, D.B. & Morris, J.G. (1987) The physiology of Clostridium sporogenes NCIB 8053 growing in defined media. J. Appl. Bacteriol. 62, 81-92. PMID 3571035.

Lovitt, R.W., Morris, J.G. & Kell, D.B. (1987) The growth and nutrition of Clostridium sporogenes NCIB 8053 in defined media. J. Appl. Bacteriol. 62, 71- 80. PMID 3571034.

Harris, C.M., Todd, R.W., Bungard, S.J., Lovitt, R.W., Morris, J.G. & Kell, D.B. (1987) The dielectric permittivity of microbial suspensions at radio frequencies: a novel method for the real-time estimation of microbial biomass. Enz. Micr. Technol. 9, 181-186.

Kell, D.B. & Walter, R.P. (1986) Organisation and control of energy metabolism in anaerobic microorganisms. In: The Organisation of Cell Metabolism (G.R. Welch & J.S. Clegg, eds.), pp. 215-231. Plenum Press, New York.

Kell, D.B. (1986) On the lateral mobility of proteins in prokaryotic membranes. Biochem. Soc. Trans. 14, 825-826. PMID 3781078.

Harris, J., Mulder, R., Kell, D.B., Walter, R.P. & Morris, J.G. (1986) Solvent production by Clostridium pasteurianum in media of high sugar content. Biotechnol. Lett. 8, 889-892.

Lovitt, R.W., Kell, D.B. & Morris, J.G. (1986) Proline reduction by Clostridium sporogenes is coupled to vectorial proton ejection. FEMS Microbiol. Lett. 36, 269- 273.

Kell, D.B. (1986) Uncoupler titrations in co-reconstituted systems do not discriminate between localized and delocalized mechanisms of photophosphorylation. Biochem. J. 236, 931-932. PMID 2878657.

Kell, D.B. & Westerhoff, H.V. (1986) Towards a rational approach to the optimization of flux in microbial biotransformations. Trends in Biotechnol. 4, 137-142.

Kell, D.B. & Westerhoff, H.V. (1986) Metabolic control theory: its role in microbiology and biotechnology. FEMS Microbiol. Rev. 39, 305-320.

Kell, D.B. (1986) Foreword. In: Modern Bioelectrochemistry (F. Gutmann & H. Keyzer, eds.) pp. x-xi. Plenum Press, New York.

Harris, C.M. & Kell, D.B. (1986) Dielectric Spectroscopy of protein translational diffusion in prokaryotic membranes. Bioelectrochem. Bioenerg. 15, 183-184.

Welch, G.R. & Kell, D.B. (1986) Not just catalysts; molecular machines in bioenergetics. In: The Fluctuating Enzyme (G.R. Welch, ed.), pp. 451-492. Wiley, New York.

Kell, D.B. (1986) Localized protonic coupling: overview and critical evaluation of techniques. Meth. Enzymol. 127, 538-557. PMID 3016471.

Kell, D.B. & Burns, A. (1986) A nomograph for calculating the optimal frequency for dielectrophoresis and the characteristic frequency of the β-dispersion of cell membrane vesicles. J. Bioelectricity, 5, 139-144.

Lovitt, R.W., Walter, R.P., Morris, J.G. & Kell, D.B. (1986) Conductimetric assessment of the biomass content in suspensions of immobilised (gel-entrapped) microorganisms. Appl. Microbiol. Biotechnol., 23, 168-173.

Kell, D.B. (1985) The electric microbe acid test [book review]. Trends Biotechnol. 3, 153-154.

Harris, C.M. & Kell, D.B. (1985) On the dielectrically observable consequences of the diffusional motions of lipids and proteins in membranes. 2. Experiments with microbial cells, protoplasts and membrane vesicles. Eur. Biophys. J. 13, 11-24. PMID 3935420.

Kell, D.B. & Harris, C.M. (1985) On the dielectrically observable consequences of the diffusional motions of lipids and proteins in membranes. 1. Theory and overview. Eur. Biophys. J. 12, 181-197. PMID 4043002.

Phillips, M.K., Rhodes-Roberts, M.E. & Kell, D.B. (1985) Tinopal AN as a selective agent for the differentiation of phytopathogenic and saprophytic Pseudomonas species. J. Appl. Bacteriol. 58, 283-292.

Harris, C.M. & Kell, D.B. (1985) The estimation of microbial biomass. Biosensors J. 1, 17-84. PMID 3916271.

Kell, D.B. & Westerhoff, H.V. (1985) Catalytic facilitation and membrane bioenergetics. In: Organized Multi-enzyme Systems: Catalytic Properties (G.R. Welch, ed.), pp. 63-139. Academic Press, New York.

Westerhoff, H.V., Melandri, B.A., Venturoli, G., Azzone, G.F. & Kell, D.B. (1985) A minimal hypothesis for membrane-linked free-energy transduction: the role of independent, small coupling units. Biochim. Biophys. Acta 768, 257-292. PMID 6095906.

Hitchens, G.D. & Kell, D.B. (1984) On the effects of thiocyanate and venturicidin on respiration-driven proton translocation in Paracoccus denitrificans. Biochim. Biophys. Acta 766, 222-232. PMID 6743650.

Kell, D.B. (1984) Constraints on the lateral diffusion of membrane proteins in prokaryotes. Trends Biochem. Sci. 9, 379.

Phillips, M.K., Rhodes-Roberts, M.E. & Kell, D.B. (1984) The anti-bacterial action of Tinopal AN. J. Gen. Microbiol. 130, 1999-2005. PMID 6206200. doi: 10.1099/00221287-130-8-1999

Kell, D.B. (1984) Diffusion of protein complexes in prokaryotic membranes: fast, free, random or directed? Trends Biochem. Sci. 9, 86-88.

Kell, D.B. (1984) Dielectric spectroscopy of the rotational and translational motions of membrane proteins: theory and experiment. EBEC Reports 3, 645-646.

Hitchens, G.D. & Kell, D.B. (1984) Effects of thiocyanate and venturicidin on respiration-driven H⁺ translocation in Paracoccus denitrificans. EBEC Reports 3, 243-244.

Kell, D.B. & Hitchens, G.D. (1984) Proton transfer pathways during bacterial electron transport phosphorylation. Biochem. Soc. Trans. 12, 413-414. PMID 6329844.

Westerhoff, H.V., Melandri, B.A., Venturoli, G., Azzone, G.F. & Kell, D.B. (1984) Mosaic protonic coupling hypothesis for free energy transduction. FEBS Lett. 165, 1-5. PMID 6319178.

Harris, C.M., Hitchens, G.D. & Kell, D.B. (1984) Dielectric properties of microbial membrane systems. In: Charge and Field Effects in Biosystems (M.J.Allen & P.N.R. Usherwood, eds.), pp. 179-185. Abacus Press, Tunbridge Wells.

Melandri BA, Azzone GF, Kell DB, Venturoli G, Westerhoff HV (1984) Is the transmembrane proton potential difference a competent intermediate in membrane- associated ATP synthesis? In Adv Photosynth Res. Edited by Sybesma C. Martinus Nijhoff/Dr W. Junk II.4.233-II.234.238.

Kell, D.B. (1983) Dielectric properties of bacterial chromatophores. Bioelectrochem. Bioenerg. 11, 405-415.

Keilmann, F. & Kell, D.B. (1983) Coherent excitation in biology. Nature 301, 656-657. PMID 6828147.

Harris, C.M. & Kell, D.B. (1983) The radio-frequency dielectric properties of yeast cells measured with a rapid, automated, frequency-domain dielectric spectrometer. Bioelectrochem. Bioenerg. 11, 15-28.

Kell, D.B. & Hitchens, G.D. (1983) Coherent properties of the membranous systems of electron transport phosphorylation. In: Coherent Excitations in Biological Systems (H. Fröhlich & F. Kremer, eds.), pp. 178-198. Springer, Berlin & Heidelberg.

Hitchens, G.D. & Kell, D.B. (1983) On the functional unit of energy coupling in photophosphorylation by bacterial chromatophores. Biochim. Biophys. Acta 723, 308-316.

Hitchens, G.D. & Kell, D.B. (1982) Uncouplers can shuttle rapidly between localised energy coupling sites during photophosphorylation by chromatophores of Rhodopseudomonas capsulata N22. Biochem. J. 212, 25-30. PMID 6870853.

Clarke, D.J., Kell, D.B., Morris, J.G. & Burns, A. (1982) The role of ion-selective electrodes in microbial process control. Ion-Selective Electrode Rev. 4, 75-131.

Kell, D.B. (1982) A rose by any other name. Trends Biochem. Sci 7, 420.

Kell, D.B. (1982) Enzymes as energy ‘funnels’? Trends Biochem. Sci. 7, 349.

Kell, D.B. & Morris, J.G. (1982) On the role of interfacial water in protonmotive systems. In: Biophysics of Water (F. Franks & S.F. Mathias, eds.), pp. 137-139. Wiley, Chichester.

Hitchens, G.D. & Kell, D.B. (1982) Localised energy coupling during photophosphorylation by chromatophores of Rhodopseudomonas capsulata N22. Biosci. Rep. 2, 743-749. PMID 6293600.

Kell, D.B. (1982) Bacteria that are resistant to uncouplers: what can they tell us? Trends Biochem. Sci. 7, 1-2.

Hitchens, G.D., Kell, D.B. & Morris, J.G. (1982) Transmembrane respiration-driven proton translocation is unimpaired in an eup mutant of Escherichia coli. J. Gen. Microbiol. 128, 2207-2209. PMID 6294225.

Hitchens, G.D. & Kell, D.B. (1982) Respiration-driven H⁺ translocation in Paracoccus denitrificans: role of the ‘permeant’ ion. Biochem. Soc. Trans. 10, 261.

Kell, D.B. & Hitchens, G.D. (1982) Respiration-driven proton translocation in Paracoccus denitrificans: role of the ‘permeant’ ion. EBEC Reports 2, 395-396.

Clarke, D.J., Morley, C.D., Kell, D.B. & Morris, J.G. (1982) On the mode of action of the bacteriocin butyricin 7423: effects on membrane potential and potassium ion accumulation in Clostridium pasteurianum. Eur. J. Biochem. 127, 105-116. PMID 6216104.

Hitchens, G.D. & Kell, D.B. (1982) On the extent of localization of the energized membrane state in chromatophores from Rhodopseudomonas capsulata N22. Biochem. J. 206, 351-357. PMID 7150247.

Phillips, M.K. & Kell, D.B. (1982) A novel inhibitor of NADH dehydrogenase in Paracoccus denitrificans. FEBS Lett. 140, 248- 250. PMID 7084467.

Clarke DJ, Kell DB, Morley CD, Morris JG: Butyricin 7423 and the membrane H⁺-ATPase of Clostridium pasteurianum. Arch Microbiol 1982; 131:81-86. PMID 6461308.

Vignais, P.M., Henry, M-F., Sim, E. & Kell, D.B. (1981) The electron transport system and hydrogenase of Paracoccus denitrificans. Curr. Top. Bioenerg. 12, 115- 196.

Kell, D.B. & Morris, J.G. (1981) Proton-coupled membrane energy trannsduction: pathways, mechanisms and control. In: Vectorial reactions in Electron and Ion Transport in Mitochondria and Bacteria (F. Palmieri, E. Quagliariello, N. Siliprandi & E.C. Slater, eds.), pp. 339-347. Elsevier/North Holland, Amsterdam.

Kell, D.B., Peck, M.W., Rodger, G. & Morris, J.G. (1981) On the permeability to weak acids and bases of the cytoplasmic membrane of Clostridium pasteurianum. Biochem. Biophys. Res. Comm. 99, 81-88. PMID 7236271.

Phillips, M.K. & Kell, D.B. (1981) A benzoxazole inhibitor of NADH dehydrogenase in Paracoccus denitrificans. FEMS Microbiol. Lett. 11,111-113.

Kell, D.B., Doddema, H.J., Morris, J.G. & Vogels, G.D. (1981) Energy coupling in methanogens. In: Microbial Growth on C1 Compounds (H. Dalton, ed.) pp. 159-170. Heyden, London.

Clarke, D.J., White, N.J.M., Burns, A., Kell, D.B. & Morris, J.G. (1981) A flexible, microprocessor-directed fermentation system for the control of hardware and monitored parameters. Proc. 2nd Eur. Congr. Biotechnol. p. 145. Society for Chemical Industry, London.

Kell, D.B., Burns, A., Clarke, D.J. & Morris, J.G. (1981) Proteinaceous proton pumps: a minimal model, some properties and their possible universality. Specul. Sci. Technol. 4, 109-120.

Kell, D.B., Clarke, D.J. & Morris, J.G. (1981) On proton-coupled information transfer along the surface of biological membranes and the mode of action of certain colicins. FEMS Microbiol. Lett. 11, 1-11.

McCarthy, J.E.G., Ferguson, S.J. & Kell, D.B. (1981) Estimation with an ion-selective electrode of the membrane potential in cells of Paracoccus denitrificans from the uptake of the butyl triphenylphosphonium cation during aerobic and anaerobic respiration. Biochem. J. 196, 311-321. PMID 7306073.

Smyth, M.R. & Kell, D.B. (1981) Polarographic investigation of some cytokinins. J. Electroanal. Chem. 122, 363-365.

Kell, D.B. & Griffiths, A.M. (1981) Polarographic assay of the binding of certain probe’ molecules to bacteriorhodopsin sheets. Photobiochem. Photobiophys. 2, 105-110.

Doddema, H.J., Claesen, C.A., Kell, D.B., van der Drift, C. & Vogels, G.D. (1980) An adenine nucleotide translocase in the procaryote Methanobacterium thermoautotrophicum. Biochem. Biophys. Res. Comm. 95, 1288-1293. PMID 6251834.

Kell, D.B. & Griffiths, A.M. (1980) The ‘energised state’ in bacteriorhodopsin sheets. EBEC Reports 1, 423-424.

Kell, D.B. (1980) The optimisation of detector systems incorporating ion-selective electrodes. In: Electroanalysis in Hygiene, Environmental, Clinical and Pharaceutical Chemistry (W.F. Smyth, ed.), pp 61-77. Elsevier, Amsterdam.

Kell, D.B. (1980) The role of ion-selective electrodes in improving fermentation yields. Process Biochemistry 15(1), 18-23, 29.

Ferguson, S.J., Sorgato, M.C., Kell, D.B. & John, P. (1979) Comparative aspects of the energetics of oxidative phosphorylation in bacteria and mitochondria. Biochem. Soc. Trans. 7, 870-874. PMID 41780.

Clarke, D.J., Kell, D.B. & Morris, J.G. (1979) The generation of a membrane potential by a fermentative bacterium. Biochem. Soc. Trans. 7, 1111-1112. PMID 510720.

Ferguson, S.J., Jones, O.T.G., Kell, D.B. & Sorgato, M.C. (1979) Comparison of permeant ion uptake and carotenoid band shift as methods for determining the membrane potential in chromatophores from Rhodopseudomonas sphaeroides Ga. Biochem. J. 180, 75-85. PMID 226068.

Kell, D.B. (1979) On the functional proton current pathway of electron transport phosphorylation: an electrodic view. Biochim. Biophys. Acta 549, 55-99. PMID 38839.

Ferguson, S.J., Gadian, D.G. & Kell, D.B. (1979) Evidence from 31P nuclear magnetic resonance that polyphosphate synthesis is a slip reaction in Paracoccus denitrificans. Biochem. Soc. Trans. 7, 176-179. PMID 437269.

Sorgato, M.C., Ferguson, S.J. & Kell, D.B. (1978) On the current-voltage relationships of energy-transducing membranes: submitochondrial particles. Biochem. Soc. Trans. 6, 1301- 1302. PMID 217779.

Kell, D.B., John, P. & Ferguson, S.J. (1978) On the current- voltage relationships of energy-transducing membranes: phosphorylating membrane vesicles from Paracoccus denitrificans. Biochem. Soc. Trans. 6, 1292-1295. PMID 217778.

Kell, D.B., Ferguson, S.J. & John, P. (1978) Measurement by a flow dialysis technique of the steady-state protonmotive force in chromatophores from Rhodospirillum rubrum: comparison with the phosphorylation potential. Biochim. Biophys. Acta 502, 111-126. PMID 416847.

Sorgato, M.C., Ferguson, S.J., Kell, D.B. & John, P. (1978) The protonmotive force in bovine heart submitochondrial particles: magnitude, sites of generation and comparison with the phosphorylation potential. Biochem. J. 174, 237-256. PMID 212021.

Kell, D.B., John, P. & Ferguson, S.J. (1978) The protonmotive force in phosphorylating membrane vesicles from Paracoccus denitrificans: magnitude, sites of generation and comparison with the phosphorylation potential. Biochem. J. 174, 257-266. PMID 212022.

Ferguson, S.J., Kell, D.B. & John, P. (1978) Resolution of Paracoccus denitrificans vesicles of differing configuration using affinity chromatography. FEMS Microbiol. Lett. 3, 151-154.

Kell, D.B., John, P., Sorgato, M.C. & Ferguson, S.J. (1978) Continuous monitoring of the electrical potential across energy- transducing membranes using ion-selective electrodes: application to submitochondrial particles and chromatophores. FEBS Lett. 86, 294-298. PMID 414935.