Dr. Steve O’Hagan
|Personal | Education | Publications | Miscellaneous | contact|
Dr Steve O’Hagan
Place of birth: Glasgow, Scotland. Date of birth: 14th September 1959
Victoria University of Manchester BSc (Hons) Chemistry. Third year specialisation: Physical Chemistry, together with options in Mathematics and in Computer Science. My third year project, with the late Prof. J.H. Baxendale, involved studying the interaction of heavy metals with miscelles using conductometry, fluorescence quenching studies and pulse radiolysis. The work was carried out in the Paterson Institute for Cancer Research (formerly “The Paterson Laboratory”) at the Christie Hospital.
Victoria University of Manchester MSc Chemistry; thesis title ‘Molecular Beam Sources’. Used mass spectrometry and time-of-flight velocity measurements to characterise the molecular species present and energy distribution of novel molecular beam sources (for potential use in reactive scattering experiments). A significant part of the work involved computer simulation to predict reaction products within the beam source from chemical kinetic data.
My MSc supervisor was the late Prof. Roger Grice.
University of Warwick PhD Chemistry; thesis title ‘Analysis of Engine Oils & Additives by Mass Spectrometry’. A variety of mass spectrometry ionisation techniques were employed to analyse engine oils and their additives, the aim of which was to find methods of coping with the complex mixtures involved. The research included extensive use of chemometrics techniques to extract individual spectra from the mass spectra of mixtures.
PhD supervisor: Prof. K.R. Jennings
O’Hagan S, Kell DB. (2015). The apparent permeabilities of Caco-2 cells to marketed drugs: magnitude, and independence from both biophysical properties and endogenite similarities PeerJ:submitted. Preprint here.
O’Hagan S, and Kell DB. 2015. Software review: The KNIME workflow environment and its applications in Genetic Programming and machine learning. Genetic Progr Evol Mach, online. doi:10.1007/s10710-015-9247-3.
O’Hagan S, Kell DB (2015) Understanding the foundations of the structural similarities between marketed drugs and endogenous human metabolites. Front Pharmacol 6, 105. DOI 10.3389/fphar.2015.00105. SYNBIOCHEM paper.
O’Hagan, S., Swainston, N., Handl, J. & Kell, D. B. (2014). A ‘rule of 0.5′ for the metabolite-likeness of approved pharmaceutical drugs. Metabolomics, in the press. doi:10.1007/s11306-014-0733-z
Dunn WB, Lin W, Broadhurst D, Begley P, Brown M, Zelena E, Vaughan AA, Halsall A, Harding N, Knowles JD, Francis-McIntyre S, Tseng A, Ellis DI, O’Hagan S, Aarons G, Benjamin B, Chew-Graham S, Moseley C, Potter P, Winder CL, Potts C, Thornton P, McWhirter C, Zubair M, Burns A, Cruickshank JK, Jayson GC, Purandare N, Wu FW, Finn JD, Haselden JN, Nicholls AW, Wilson ID, Goodacre R, Kell DB: Molecular phenotyping of a UK population: defining the human serum metabolome. Metabolomics 2014:in the press.
Ellis, D.I., Cowcher, D.P., Ashton, L., O’Hagan, S. and Goodacre, R. (2013) Illuminating disease and enlightening biomedicine: Raman spectroscopy as a diagnostic tool. Analyst, 138(14), 3871-3884 doi:10.1039/C3AN00698K
O’Hagan, S., Knowles, J. & Kell, D. B. (2012). Exploiting genomic knowledge in optimising molecular breeding programmes: algorithms from evolutionary computing. PLoS ONE 7, e48862.
Brown, M., Dunn, W.B., Ellis, D.I., Goodacre, R., Handl, J., Knowles, J.D., O’Hagan, S., Spasić, I. & Kell, D.B. (2005) A metabolome pipeline: from concept to data to knowledge. Metabolomics 1(1), 39-51.
O’Hagan, S., Dunn, W.B., Brown, M., Knowles, J.D. & Kell, D.B. (2005) Closed-loop, multiobjective optimization of analytical instrumentation: gas chromatography/time-of-flight mass spectrometry of the metabolomes of human serum and of yeast fermentations. Anal. Chem 77, 290-303.
Ellis, D.I., O’Hagan, S., Dunn, W.B., Brown, M. and Vaidyanathan, S. (2004) From genomes to systems. Genome Biology 5(11), 354.
I am a member of the Royal Society Chemistry (RSC).
After several years working in Hong Kong for various commercial laboratories as Laboratory Technical Manager / Quality Assurance Manager / IT Manager, I returned to the UK in 2002, after a couple of jobs with Pfizer in Kent and Alcontrol Laboratories in Chester, I joined Doug’s research group in 2003. (When we were still part of UMIST).
My research interests include: Developing utilities and applications using various programming languages in the areas of :- Genetic and evolutionary programming; laboratory automation; analytical laboratory data analysis (including univariate and multivariate statistics); chemometrics; laboratory information management systems; and computer modelling of biological systems.
If you wish to contact me, please use the following contact details:
School of Chemistry
The University of Manchester
Manchester Institute of Biotechnology
University of Manchester
131, Princess St
Manchester M1 7DN
|Personal | Education | Publications | Miscellaneous | Contact|
Last updated: August 4, 2015 at 11:23 am