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Introduction

Here are all the papers referenced in the MCA Web plus some others that I found of sufficient interest to include. Since all the citations are hyper-linked to the entries in this page, the references here are not in alphabetical order, but rather in an arbitrary order. This is **not** a complete list of MCA references, for more complete lists please read the reviews cited below or do a bibliographic search.

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Fundamental Papers

Kacser, H. & Burns, J.A. (1973) The control of flux. *Symp. Soc. Exp. Biol. ***27**, 65-104.

Burns, J.A. (1971) Studies on complex enzyme systems. PhD thesis, Univ of Edinburgh, now on the Web.

Heinrich, R. & Rapoport, T.A. (1974) A linear steady-state treatment of enzymatic chains. General properties, control and effector strength., *Eur. J. Biochem. ***42**, 89-95.

Burns, J.A., Cornish-Bowden, A., Groen, A.K., Heinrich, R., Kacser, H., Porteous, J.W., Rapoport, S.M., Rapoport T.A., Stucki, J.W., Tager, J.M., Wanders, R.J.A. & Westerhoff, H.V. (1985), Control of metabolic systems. *Trends Biochem. Sci. ***10**, 16.

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Theoretical Advances

Heinrich, R. & Rapoport, T.A. (1975) Mathematical analysis of multienzyme systems. II. Steady-state and transient control. *BioSystems ***7**, 130-136.

Kacser, H. (1983) The control of enzyme systems *in vivo*: elasticity analysis of the steady state. *Biochem. Soc. Trans. ***11**, 35-40.

Reder, C. (1988) Metabolic control theory: a structural approach. *J. Theoret. Biol. ***135**, 175-201.

Westerhoff, H.V. & Chen, Y.-D. (1984) How do enzyme activities control metabolite concentrations? An additional theorem in the theory of metabolic control. *Eur. J. Biochem. ***142**, 425-430

Westerhoff, H.V. & Kell, D.B. (1987) Matrix method for determining the steps most rate-limiting to metabolic fluxes in biotechnological processes. *Biotechnol. Bioeng. ***30**, 101-107.

Fell, D.A. & Sauro, H.M. (1985) Metabolic control and its analysis. Additional relationships between elasticities and control coefficients. *Eur. J. Biochem. ***148**, 555-561.

Sauro, H.M., Small, J.R. & Fell, D.A. (1987) Metabolic control and its analysis. Extensions to the theory and matrix method. *Eur. J. Biochem. ***165**, 215-221.

Small, J.R. & Fell, D.A. (1989) The matrix method of metabolic control analysis: its validity for complex pathway structures. *J. Theoret. Biol. ***136**, 181-197.

Hofmeyr, J.-H.S., Kacser, H. & van der Merwe, K.J. (1986) Metabolic control analysis of moiety-conserved cycles. *Eur. J. Biochem. ***155**, 631-641.

Small, J.R. & Fell, D.A. (1989) The matrix method of metabolic control analysis: its validity for complex pathway structures. *J. Theoret. Biol. ***136**, 181-197.

Cascante, M., Franco, R. & Canela, E.I. (1989a) Use of implicit methods from general sensitivity theory to develop a systematic approach to metabolic control. 1. Unbranched pathways. *Math. Biosci.* **94**, 271-288.

Cascante, M., Franco, R., and Canela, E.I. (1989b), Use of implicit methods from general sensitivity theory to develop a systematic approach to metabolic control. 2. Complex systems. *Math. Biosci.* **94**, 289-309 .

Giersch, C. (1988) Control analysis of metabolic networks. 1. Homogeneous functions and the summation theorems for control coefficients. *Eur. J. Biochem. ***174**, 509-513.

Acerenza, L., Sauro, H.M. & Kacser, H. (1989) Control analysis of time-dependent metabolic systems. *J. Theoret. Biol. ***137**, 423-444.

Kohn, M.C. & Chiang, E. (1982) Metabolic network sensitivity analysis. *J. Theoret. Biol. ***98**, 109-126.

Markus, M. & Hess, B. (1990) Control of metabolic oscillations: unpredictability, critical slowing down, optimal stability and hysteresis. In *Control of Metabolic Processes.* (Cornish-Bowden, A. & Cárdenas, M. eds), Plenum Press, New York, pp. 303-313.

Westerhoff, H.V. & Kell, D.B. (1988) A control theoretic analysis of inhibitor titration assays of metabolic channeling. *Comments Mol. Cell. Biophys. ***5**, 57-107.

Kell, D.B. & Westerhoff, H.V. (1990) Control analysis of organised multienzyme systems. In: *Structural and organizational aspects of metabolic regulation*, UCLA Symposia on Molecular and Cellular Biology, New Series, Vol 134 (P. Srere, M.E. Jones and C. Mathews, eds), pp. 273-289. Alan R. Liss, New York.

Kacser, H., Sauro, H.M. & Acerenza, L. (1990) Enzyme-enzyme interactions and control analysis. 1. The case of nonadditivity: monomer-oligomer associations. *Eur. J. Biochem. ***187**, 481-491.

Sauro, H.M. & Kacser, H. (1990) Enzyme-enzyme interactions and control analysis. 2. The case of nonindependence: heterologous associations. *Eur. J. Biochem. ***187**, 493-500.

Kholodenko, B.N. & Westerhoff, H.V. (1993) Metabolic channelling and control of the flux. *FEBS Lett. ***320**, 71-74.

van Dam, K., van der Vlag, J., Kholodenko, B.N. & Westerhoff, H.V. (1993) The sum of the flux control coefficients of all enzymes on the flux through a group-transfer pathway can be as high as two. *Eur. J. Biochem. ***212**, 791-799.

Cárdenas, M.L. & Cornish-Bowden, A. (1989) Characteristics necessary for an interconvertible enzyme cascade to generate a highly sensitive response to an effector. *Biochem. J. ***257**, 339-345.

Small, J.R. & Fell, D.A. (1990) Covalent modification and metabolic control analysis. Modification to the theorems and their application to metabolic systems containing covalently modifiable enzymes. *Eur. J. Biochem. ***191**, 405-411.

Schuster, S., Kahn, D. & Westerhoff, H.V. (1993) Modular analysis of the control of complex metabolic pathways. *Biophys. Chem. ***48**, 1-17.

Westerhoff, H.V., Hofmeyr, J.-H.S. & Kholodenko, B.N. (1994) Getting to the inside of cells using metabolic control analysis. *Biophys. Chem. ***50**, 273-283.

Meléndez Hevia, E., Torres, N.V., Sicilia, J. & Kacser, H. (1990) Control analysis of transition times in metabolic systems. *Biochem. J. ***265**, 195-202.

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Reviews

Cornish-Bowden, A. (1995) Metabolic control analysis in theory and practice. *Adv. Mol. Cell Biol. ***11**, 21-64.

Fell, D.A. (1992) Metabolic control analysis – a survey of its theoretical and experimental development. *Biochem. J. ***286**, 313-330.

Schuster, S. & Heinrich, R. (1992) The definitions of metabolic control analysis revisited. *BioSystems ***27**, 1-15.

Kell, D.B., van Dam, K. & Westerhoff, H.V. (1989) Control analysis of microbial growth and productivity. *Symp. Soc. Gen. Microbiol. ***44**, 61-93.

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Books

Westerhoff, H.V. & van Dam, K. (1987) *Thermodynamics and Control of Biological Free-energy Transduction.* Amsterdam, Elsevier.

Cornish-Bowden, A. & Cárdenas, M.L. (eds.) (1990) *Control of metabolic processes.*, New York, Plenum Press.

Fell, D. A. (1996) *Understanding the Control of Metabolism.*. London, Portland Press.

Heinrich, R. & Schuster, S. (1996) *The regulation of cellular systems.*. New York, Chapman & Hall.

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Experimental

Groen, A.K., Wanders, R.J.A., Westerhoff, H.V., van der Meer, R. and Tager, J.M. (1982) Quantification of the contribution of various steps to the control of mitochondrial respiration. *J. Biol. Chem. ***257**, 2754-2757.

Niederberger, P., Prasad, R., Miozzari, G. & Kacser, H. (1982) A strategy for increasing an in vivo flux by genetic manipulations. The tryptophan system of yeast. Biochem. J. **287**, 473-479.

Flint, H.J., Tateson, R.W., Barthelmess, I.B., Porteous, D.J., Donachie, W.D. and Kacser, H. (1981) Control of the flux in the arginine pathway of Neurospora crassa. Modulations of enzyme activity and concentration. *Biochem. J ***200**, 231-246.

Torres, N.V., Mateo, F., Meléndez-Hevia, E. & Kacser, H. (1986) Kinetics of metabolic pathways. A system *in vitro* to study the control of flux. *Biochem. J. ***234**, 169-174.

Small, J.R. (1993) Flux control coefficients determined by inhibitor titration: the design and analysis of experiments to minimize errors *Biochem. J. ***296**, 423-433.

Brown, G.C., Hafner, R.P. & Brand, M.D. (1990) A 'top-down' approach to the determination of control coefficients in metabolic control theory. *Eur. J. Biochem. ***188**, 321-325.

Delgado, J. & Liao, J.C. (1992), Determination of flux control coefficients from transient metabolite concentrations *Biochem. J. ***282**, 919-927.

Delgado, J., and Liao, J.C. (1992), Metabolic control analysis using transient metabolite concentrations. Determination of metabolite concentration control coefficients. *Biochem. J. ***285**, 965-972.

Groen, A.K., van Roermund, C.W.T., Vervoorn, R. & Tager, J.M. (1986), Control of gluconeogenesis in rat liver cells. Flux control coefficients of the enzymes in the gluconeogenic pathway in the absence and presence of glucagon. *Biochem. J. ***237**, 379-389.

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Software

Mendes, P. (1993) GEPASI: a software package for modelling the dynamics, steady states and control of biochemical and other systems. *Comput. Appl. Biosci. ***9**, 563-571.

Letellier, T., Reder, C. & Mazat, J. P. (1991) CONTROL – software for the analysis of control of metabolic networks. *Comput. Applic. Biosci. ***7**, 383-390.

Thomas, S. & Fell, D.A. (1993) A computer program for the algebraic determination of control coefficients in metabolic control analysis. *Biochem. J. ***292**, 351-360.

Sauro, H. M. (1993) SCAMP: a general-purpose simulator and metabolic control analysis program. *Comput. Appl. Biosci. ***9**, 441-450.

Sauro, H.M. & Fell, D.A. (1991) SCAMP: A metabolic simulator and control analysis program. *Math. Comput. Modelling ***15**, 15-28.

Cornish-Bowden, A. & Hofmeyr, J.-H.S. (1991), MetaModel: a program for modelling and control analysis of metabolic pathways on the IBM PC and compatibles. *Comput. Applic. Biosci. ***7**, 89-93.

Ehlde, M. & Zacchi, G. (1995). MIST: a user-friendly metabolic simulator. *Comput. Appl. Biosci.* **11**, 201-207.

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Related Topics

Reich, J.G. & Sel'kov, E.E. (1981) *Energy metabolism of the cell. A theoretical treatise.* Academic Press, London.

Keleti, T. (1986) *Basic enzyme kinetics.*, Akadémiai Kiadó, Budapest.

Cornish-Bowden, A. (1995) *Fundamentals of enzyme kinetics.* (2nd edition) Portland Press, London

Srere, P.A. (1987) Complexes of sequential metabolic enzymes. *Ann. Rev. Biochem. ***56**, 21-56.

Ovádi, J. (1991) Physiological significance of metabolic channelling. *J. Theoret. Biol. ***152**, 1-22.

Mendes, P., Kell, D.B. & Welch, G.R. (1995) Metabolic channeling in organized enzyme systems: experiments and models. *Adv. Mol. Cell Biol. ***11**, 1-19.

Stucki, J.W. (1978). Stability analysis of biochemical systems. A practical guide. *Progr. Biophys. Mol. Biol.* **33**, 99-187.

Chock, P.B. & Stadtman, E.R. (1980) Covalently interconvertible enzyme cascade systems. *Methods Enzymol. ***64**, 297-325.

Last updated: March 28, 2013 at 15:59 pm