A ‘Canon’ of Reviews on Metabolic Organisation, Channeling and Control


A number of people have suggested that it would be of great benefit to scientists who are starting to develop a detailed interest in the question of what the inside of cells is really like, and in the (probably) related questions of the organisation of metabolic channeling and the control of metabolic fluxes, to have access to a short bibliography that would serve to outline most of the issues, and to summarise the evidence that leads many to believe that the inside of a cell is far more organised than textbooks usually credit. There follows a short and necessarily eclectic selection that we believe will be helpful. indicates what might be considered the first 5.

The Reviews

Welch, G. R. (1977). On the role of organized multienzyme systems in cellular metabolism: a general synthesis. Prog. Biophys. Molec. Biol. 32, 103-191.

Srere, P.A. & Estabrook, R.W. (eds) Microenvironments and metabolic compartmentation. Academic Press, New York, 1978.

Clegg, J. S. (1984). Properties and metabolism of the aqueous cytoplasm and its boundaries. Am. J. Physiol. 246, R133-R151

[various] (1984) J.Cell Biol. 99 (No.1, part 2) pp 3S-248S (S for supplement) "The Cytoplasmic Matrix and Cellular Function".

Welch, G.R. (ed.) Organized Multi-enzyme Systems: Catalytic Properties. Academic Press, New York, 1985.

Welch, G.R. & Clegg, J.S. (eds). The Organisation of Cell Metabolism, Plenum Press, New York, 1986.

Welch, G.R. (ed) The Fluctuating Enzyme, Wiley, New York, 1986.

Srere, P. A. (1987). Complexes of sequential metabolic enzymes. Annu. Rev. Biochem. 56, 21- 56.

Westerhoff, H.V. & van Dam, K. Thermodynamics and Control of Biological Free-energy Transduction. Amsterdam: Elsevier, 1987.

Jones, D.P. (ed.), Microcompartmentation. CRC Press, Boca Ration, FL, 1988.

Srere, P., Jones, M.E. & Mathews, C. (eds) Structural and organizational aspects of metabolic regulation, UCLA Symposia on Molecular and Cellular Biology, New Series, Vol 134, Alan R. Liss, New York, 1990.

Cornish-Bowden, A. & Cárdenas, M.L. Control of metabolic processes. NATO ASI Series Vol 190. Plenum Press, New York, 1990.

Ovádi, J. (1991). Physiological significance of metabolic channelling. J. Theoret. Biol. 152, 1-22 (and some, but by no means all, of the papers in this special issue of JTB).

Stadtman, E.R. & Chock, P.B. (eds) From metabolite to metabolism to metabolon. Current Topics in Cellular Regulation Vol 33. Academic Press, New York, 1992.

Brindle, K. (ed.) Enzymology in vivo (Adv. Mol. Cell. Biol. 11) JAI Press, London, 1995.

Kacser, H., Burns, J.A. & Fell, D.A. (1995) The control of flux. Biochem. Soc. Trans. 23, 341- 366

Ovádi, J. Cell architecture and metabolic channeling. Springer-Verlag, New York, 1995.

Fell, D.A. Understanding metabolic control. Portland Press, London, 1996.

Heinrich, R. & Schuster, S. (1996) The Regulation of Cellular Systems. Chapman & Hall, New York.

A summary of the abundant evidence that bulk-phase chemiosmotic coupling does not serve to account for energy transduction in oxidative and photosynthetic phosporylation may be found in Kell, D.B., Protonmotive energy-transducing systems: some physical principles and experimental approaches. In: Bacterial Energy Transduction (C.J. Anthony, ed.), pp. 429-490. Academic Press, London, 1988.

Suggestions for amendments to the canon are welcome, but there is a rule that says that you can't suggest your own publications!  cheeky‚Äč