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MCA |
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Back to the MCA homepage.
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Several programs are available that are useful for various aspects
of MCA, below are brief descriptions of some of these.
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Metabolic Simulators |
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These programs simulate the behaviour of metabolic pathways and then
calculate the various MCA coefficients for the simulated states. They can be
used for modelling, not just for control analysis.
- Gepasi by Mendes
(1993) is a free ms windows program for
simulation of steady states and transient behaviour of biochemical pathways
(including several compartments). it calculates all the enzyme elasticities,
flux- and concentration-control coefficients, as well as their unscaled
versions (Reder 1988) for steady states.
- SCAMP
by Sauro & Fell (1991,
Sauro 1993) is a free command line driven
compiler of metabolic pathways for the atari st and ms-dos. scamp simulates
steady states and transient behaviour of metabolic pathways and calculates all
the coefficients of mca (for both steady states and transient states, see
Acerenza et al. 1989 for the latter).
- MIST
by Magnus Ehlde
(1995) is a free MS Windows 3.1 simulator
that can calculate control coefficients of the simulated pathways.
- MetaModel
by cornish-bowden & hofmeyr (1991) is
an ms-dos simulator of the steady states of metabolic pathways. metamodel
calculates the control coefficients of the steady states. a test version of
metamodel 3 is available from
ftp://bmshuxley.brookes.ac.uk/pub/software/ibmpc/metamod3/.
- DBSolve
by Igor Goryanin is a free windows 95 and nt (intel only) simulator with links
to the EMP database.
- SCoP is
a commercial simulation program oriented towards biological applications. It
can be used to simulate metabolic systems (there is no information about its
capabilities for calculating elasticity and control coefficients).
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Programs for Calculation of MCA Coefficients |
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In this class are programs that apply some
matrix method to calculate enzyme elasticities,
control coefficients or response coefficients.
- CONTROL by Letellier et al.
(1991), uses the Reder
(1988) matrix method to calculate control
coefficients from values of elasticities. CONTROL is available for MS-DOS.
- MetaCon by Thomas & Fell (1993)
uses the Fell & Sauro (1985, Sauro et al. 1987) matrix method.
It calculates algebraic expressions of the control coefficients as functions of
the elasticities and can substitute polynomial expressions or numerical values
for any or all variables (metabolite concentrations, fluxes and enzyme
elasticities). This program is also capable doing sensitivity analysis of
control coefficients. MetaCon runs under MS-DOS and is available from
ftp://bmshuxley.brookes.ac.uk/pub/software/ibmpc/metacon/
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General Mathematics Programs |
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This type of programs are not specific for MCA but can be used for that
purpose. Most are commercial (but there are good free packages too).
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Group |
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Back to the group's homepage.
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