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Here are all the papers referenced in the MCA Web
plus some others that I found of sufficient interest to include. Since all
the citations are hyper-linked to the entries in this page, the references
here are not in alphabetical order, but rather in an arbitrary order. This is
not a complete list of MCA references, for more complete lists please
read the reviews cited below or do a bibliographic
search.
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Fundamental Papers |
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Kacser, H. & Burns, J.A. (1973) The control of
flux. Symp. Soc. Exp. Biol. 27, 65-104.
Burns, J.A. (1971) Studies on complex enzyme
systems. PhD thesis, Univ of Edinburgh,
now on the Web.
Heinrich, R. & Rapoport, T.A. (1974) A
linear steady-state treatment of enzymatic chains. General properties, control
and effector strength., Eur. J. Biochem. 42, 89-95.
Burns, J.A., Cornish-Bowden, A., Groen, A.K.,
Heinrich, R., Kacser, H., Porteous, J.W., Rapoport, S.M., Rapoport T.A.,
Stucki, J.W., Tager, J.M., Wanders, R.J.A. & Westerhoff, H.V. (1985),
Control of metabolic systems. Trends Biochem. Sci. 10, 16.
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Theoretical Advances |
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Heinrich, R. & Rapoport, T.A. (1975)
Mathematical analysis of multienzyme systems. II. Steady-state and transient
control. BioSystems 7, 130-136.
Kacser, H. (1983) The control of enzyme
systems in vivo: elasticity analysis of the steady state. Biochem.
Soc. Trans. 11, 35-40.
Reder, C. (1988) Metabolic control theory: a
structural approach. J. Theoret. Biol. 135, 175-201.
Westerhoff, H.V. & Chen, Y.-D. (1984) How
do enzyme activities control metabolite concentrations? An additional theorem
in the theory of metabolic control. Eur. J. Biochem. 142,
425-430
Westerhoff, H.V. & Kell, D.B. (1987) Matrix
method for determining the steps most rate-limiting to metabolic fluxes in
biotechnological processes. Biotechnol. Bioeng. 30, 101-107.
Fell, D.A. & Sauro, H.M. (1985) Metabolic
control and its analysis. Additional relationships between elasticities and
control coefficients. Eur. J. Biochem. 148, 555-561.
Sauro, H.M., Small, J.R. & Fell, D.A.
(1987) Metabolic control and its analysis. Extensions to the theory and matrix
method. Eur. J. Biochem. 165, 215-221.
Small, J.R. & Fell, D.A. (1989) The matrix
method of metabolic control analysis: its validity for complex pathway
structures. J. Theoret. Biol. 136, 181-197.
Hofmeyr, J.-H.S., Kacser, H. & van der
Merwe, K.J. (1986) Metabolic control analysis of moiety-conserved cycles.
Eur. J. Biochem. 155, 631-641.
Small, J.R. & Fell, D.A. (1989) The
matrix method of metabolic control analysis: its validity for complex pathway
structures. J. Theoret. Biol. 136, 181-197.
Cascante, M., Franco, R. & Canela, E.I.
(1989a) Use of implicit methods from general sensitivity theory to develop a
systematic approach to metabolic control. 1. Unbranched pathways. Math.
Biosci. 94, 271-288.
Cascante, M., Franco, R., and Canela, E.I.
(1989b), Use of implicit methods from general sensitivity theory to develop a
systematic approach to metabolic control. 2. Complex systems. Math.
Biosci. 94, 289-309 .
Giersch, C. (1988) Control analysis of
metabolic networks. 1. Homogeneous functions and the summation theorems for
control coefficients. Eur. J. Biochem. 174, 509-513.
Acerenza, L., Sauro, H.M. & Kacser, H.
(1989) Control analysis of time-dependent metabolic systems. J. Theoret.
Biol. 137, 423-444.
Kohn, M.C. & Chiang, E. (1982) Metabolic
network sensitivity analysis. J. Theoret. Biol. 98, 109-126.
Markus, M. & Hess, B. (1990) Control of
metabolic oscillations: unpredictability, critical slowing down, optimal
stability and hysteresis. In Control of Metabolic Processes.
(Cornish-Bowden, A. & Cárdenas, M. eds), Plenum Press, New York, pp.
303-313.
Westerhoff, H.V. & Kell, D.B. (1988) A
control theoretic analysis of inhibitor titration assays of metabolic
channeling. Comments Mol. Cell. Biophys. 5, 57-107.
Kell, D.B. & Westerhoff, H.V. (1990) Control
analysis of organised multienzyme systems. In: Structural and organizational
aspects of metabolic regulation, UCLA Symposia on Molecular and Cellular
Biology, New Series, Vol 134 (P. Srere, M.E. Jones and C. Mathews, eds), pp.
273-289. Alan R. Liss, New York.
Kacser, H., Sauro, H.M. & Acerenza, L.
(1990) Enzyme-enzyme interactions and control analysis. 1. The case of
nonadditivity: monomer-oligomer associations. Eur. J. Biochem.
187, 481-491.
Sauro, H.M. & Kacser, H. (1990) Enzyme-enzyme
interactions and control analysis. 2. The case of nonindependence: heterologous
associations. Eur. J. Biochem. 187, 493-500.
Kholodenko, B.N. & Westerhoff, H.V. (1993)
Metabolic channelling and control of the flux. FEBS Lett. 320,
71-74.
van Dam, K., van der Vlag, J., Kholodenko,
B.N. & Westerhoff, H.V. (1993) The sum of the flux control coefficients of
all enzymes on the flux through a group-transfer pathway can be as high as two.
Eur. J. Biochem. 212, 791-799.
Cárdenas, M.L. & Cornish-Bowden,
A. (1989) Characteristics necessary for an interconvertible enzyme cascade to
generate a highly sensitive response to an effector. Biochem. J.
257, 339-345.
Small, J.R. & Fell, D.A. (1990) Covalent
modification and metabolic control analysis. Modification to the theorems and
their application to metabolic systems containing covalently modifiable
enzymes. Eur. J. Biochem. 191, 405-411.
Schuster, S., Kahn, D. & Westerhoff,
H.V. (1993) Modular analysis of the control of complex metabolic pathways.
Biophys. Chem. 48, 1-17.
Westerhoff, H.V., Hofmeyr, J.-H.S. &
Kholodenko, B.N. (1994) Getting to the inside of cells using metabolic control
analysis. Biophys. Chem. 50, 273-283.
Meléndez Hevia, E., Torres, N.V.,
Sicilia, J. & Kacser, H. (1990) Control analysis of transition times in
metabolic systems. Biochem. J. 265, 195-202.
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Reviews |
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Cornish-Bowden, A. (1995) Metabolic control
analysis in theory and practice. Adv. Mol. Cell Biol. 11,
21-64.
Fell, D.A. (1992) Metabolic control analysis - a
survey of its theoretical and experimental development. Biochem. J.
286, 313-330.
Schuster, S. & Heinrich, R. (1992) The
definitions of metabolic control analysis revisited. BioSystems
27, 1-15.
Kell, D.B., van Dam, K. & Westerhoff,
H.V. (1989) Control analysis of microbial growth and productivity. Symp.
Soc. Gen. Microbiol. 44, 61-93.
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Books |
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Westerhoff, H.V. & van Dam, K. (1987)
Thermodynamics and Control of Biological Free-energy Transduction.
Amsterdam, Elsevier.
Cornish-Bowden, A. & Cárdenas, M.L.
(eds.) (1990) Control of metabolic processes., New York, Plenum Press.
Fell, D. A. (1996) Understanding the Control
of Metabolism.. London, Portland Press.
Heinrich, R. & Schuster, S. (1996)
The regulation of cellular systems.. New York, Chapman & Hall.
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Experimental |
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Groen, A.K., Wanders, R.J.A., Westerhoff, H.V.,
van der Meer, R. and Tager, J.M. (1982) Quantification of the contribution of
various steps to the control of mitochondrial respiration. J. Biol. Chem.
257, 2754-2757.
Niederberger, P., Prasad, R., Miozzari,
G. & Kacser, H. (1982) A strategy for increasing an in vivo flux by genetic
manipulations. The tryptophan system of yeast. Biochem. J. 287,
473-479.
Flint, H.J., Tateson, R.W., Barthelmess, I.B.,
Porteous, D.J., Donachie, W.D. and Kacser, H. (1981) Control of the flux in the
arginine pathway of Neurospora crassa. Modulations of enzyme activity and
concentration. Biochem. J 200, 231-246.
Torres, N.V., Mateo, F.,
Meléndez-Hevia, E. & Kacser, H. (1986) Kinetics of metabolic
pathways. A system in vitro to study the control of flux. Biochem. J.
234, 169-174.
Small, J.R. (1993) Flux control coefficients
determined by inhibitor titration: the design and analysis of experiments to
minimize errors Biochem. J. 296, 423-433.
Brown, G.C., Hafner, R.P. & Brand, M.D.
(1990) A 'top-down' approach to the determination of control coefficients in
metabolic control theory. Eur. J. Biochem. 188, 321-325.
Delgado, J. & Liao, J.C. (1992),
Determination of flux control coefficients from transient metabolite
concentrations Biochem. J. 282, 919-927.
Delgado, J., and Liao, J.C. (1992),
Metabolic control analysis using transient metabolite concentrations.
Determination of metabolite concentration control coefficients. Biochem. J.
285, 965-972.
Groen, A.K., van Roermund, C.W.T., Vervoorn, R.
& Tager, J.M. (1986), Control of gluconeogenesis in rat liver cells. Flux
control coefficients of the enzymes in the gluconeogenic pathway in the absence
and presence of glucagon. Biochem. J. 237, 379-389.
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Software |
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Mendes, P. (1993) GEPASI: a software package
for modelling the dynamics, steady states and control of biochemical and other
systems. Comput. Appl. Biosci. 9, 563-571.
Letellier, T., Reder, C. & Mazat, J. P.
(1991) CONTROL - software for the analysis of control of metabolic networks.
Comput. Applic. Biosci. 7, 383-390.
Thomas, S. & Fell, D.A. (1993) A computer
program for the algebraic determination of control coefficients in metabolic
control analysis. Biochem. J. 292, 351-360.
Sauro, H. M. (1993) SCAMP: a general-purpose
simulator and metabolic control analysis program. Comput. Appl. Biosci.
9, 441-450.
Sauro, H.M. & Fell, D.A. (1991) SCAMP: A
metabolic simulator and control analysis program. Math. Comput. Modelling
15, 15-28.
Cornish-Bowden, A. & Hofmeyr, J.-H.S.
(1991), MetaModel: a program for modelling and control analysis of metabolic
pathways on the IBM PC and compatibles. Comput. Applic. Biosci.
7, 89-93.
Ehlde, M. & Zacchi, G. (1995). MIST: a
user-friendly metabolic simulator. Comput. Appl. Biosci. 11,
201-207.
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Related Topics |
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Reich, J.G. & Sel'kov, E.E. (1981)
Energy metabolism of the cell. A theoretical treatise. Academic Press,
London.
Keleti, T. (1986) Basic enzyme
kinetics., Akadémiai Kiadó, Budapest.
Cornish-Bowden, A. (1995) Fundamentals of
enzyme kinetics. (2nd edition) Portland Press, London
Srere, P.A. (1987) Complexes of sequential
metabolic enzymes. Ann. Rev. Biochem. 56, 21-56.
Ovádi, J. (1991) Physiological
significance of metabolic channelling. J. Theoret. Biol. 152,
1-22.
Mendes, P., Kell, D.B. & Welch, G.R.
(1995) Metabolic channeling in organized enzyme systems: experiments and
models. Adv. Mol. Cell Biol. 11, 1-19.
Stucki, J.W. (1978). Stability analysis of
biochemical systems. A practical guide. Progr. Biophys. Mol. Biol.
33, 99-187.
Chock, P.B. & Stadtman, E.R. (1980)
Covalently interconvertible enzyme cascade systems. Methods Enzymol.
64, 297-325.
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Group |
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Back to the group's homepage.
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