GORDON RESEARCH CONFERENCE ON MACROMOLECULAR ORGANIZATION AND CELL FUNCTION

QUEEN’S COLLEGE, OXFORD, Sept 13-17 1998

SUNDAY SEPT 13th

12 pm - 6 pm (and 7 pm - 9 pm) REGISTRATION

5-00 P.M. MIXER Front Quad Cloisters

6-00 P.M. DINNER (Queen’s College Hall)

SUNDAY PM

Cell Structure and Microenvironments

Discussion Leader: Jim Clegg
Bodega Bay Marine Laboratory, Univ. of California-Davis

7-15 Introduction and Welcome

7-25 Evolving Concepts of Cell Structure and the Intracellular Milieu: A Historical Perspective
Jim Clegg

Bodega Bay Marine Laboratory, Univ. of California, Davis

8-10 Organization of Cellular Water
Adrian Parsegian
Laboratory of Structural Biology, NIH

8-55 Break

9-05 Control of Intracellular Transport by the Cytoplasmic Architecture
Kate Luby-Phelps
Dept. of Physiology, Univ. of Texas Southwestern Medical Center

9-50 GENERAL DISCUSSION

MONDAY SEPT 14th

Breakfast 7-45 - 8-45 Queen’s College Hall

MONDAY AM

Cellular Mobility and Intracellular Transport

Discussion Leader: Kate Luby-Phelps,Dept. of Physiology, U. T. Southwestern Medical Center

9-00 Imaging Intracellular Trafficking
Thomas Jovin

Dept. of Molecular Biology, Max Planck Inst. for Biophysical Chemistry, Göttingen

9-45 Cytokinesis and Cell Locomotion
Kevin Burton

Science and Technology Center, Carnegie Mellon Univ.

10-30 COFFEE

11-00 Axonal Transport
Scott Brady
Dept Cell Biology and Neuroscience, Univ. of Texas Southwestern Medical Center

11-45 Cytoskeletal Function in Plant Cells
Mel Schindler

Dept. of Biochemistry, Michigan State Univ.

12-30 GENERAL DISCUSSION

1-00 PHOTOGRAPH (Queen’s College)

1-30 LUNCH

4-00 - 6-00 POSTER SESSION 1 (College Bar open)

6-00 DINNER

MONDAY PM

Molecular Basis for Channeled Metabolism

Discussion Leader: Paul Srere

VA Medical Center, Dallas, TX

7-15 Principles of protein-protein interactions

Susan Jones

Dept of Biochemistry, Unibersity College, London

8-00 Protein-Protein Interaction and the Molecular Mechanism of Substrate Channelling in 2-Oxo Acid Dehydrogenase Complexes
Richard Perham

Dept. of Biochemistry, Univ. of Cambridge

8-45 Break

8-55 Tryptophan Synthase: Allosteric Regulation of Substrate Channeling
Michael Dunn

9-40 GENERAL DISCUSSION

TUESDAY SEPT 15th

Breakfast 7-45 - 8-45 Queen’s College Hall

TUESDAY AM

Non-invasive Approaches for Exploring Macromolecular and Cellular Organization

Discussion Leader: Douglas Kell

Institute of Biological Sciences, Univ. of Wales, Aberystwyth

9-00 Luminescent Indicator and Reporter Genes
Tony Campbell

Dept. of Medical Biochemistry, Univ. of Wales, Cardiff

9-45 Detection and localization of genes and gene products by fluorescence microcopy in prokaryotes: linking genotype and phenotype?

Nanne Nanninga
Institute of Molecular and Cellular Biology, University of Amsterdam.

10-30 COFFEE

11-00 Spectroscopic Analysis of Proteins in vivo
Kevin Brindle

Dept. of Biochemistry, Univ. of Cambridge

11-45 Detection of Protein-Protein Interactions with the Reverse Two Hybrid System
Marc Vidal

Massachusetts General Hospital Cancer Center, Harvard Univ.

12-30 GENERAL DISCUSSION

1-00 LUNCH (Queen’s College Hall)

AFTERNOON FREE

6-00 DINNER

TUESDAY PM

Enzyme Organization and Channeled Metabolism

Discussion Leader Harvey Knull

University of North Dakota

7-15 Protein-Protein Interactions Within the Bcl-2 Family: Importance in the Regulation of Apoptosis.
Caroline Dive

Univ. of Manchester

8-00 Structural and Functional Organisation of Polyketide Synthases
Peter Leadlay

Univ. of Cambridge

8-45 Break

8-55 Production and Modelling of Krebs TCA Cycle Enzyme Fusions to Study the Metabolon Hypothesis
Christian Vélot, VA Medical Center, Dallas, TX

9-40 GENERAL DISCUSSION

WEDNESDAY SEPT 16th

Breakfast 7-45 - 8-45 Queen’s College Hall

WEDNESDAY AM

Organization of Gene Expression

Discussion Leader: Chris Mathews

Dept. of Biochemistry and Biophysics, Oregon State Univ.

9-00 Nucleotide/DNA Synthesis
Chris Mathews
Dept. of Biochemistry and Biophysics, Oregon State Univ.

9-45 Nucleosome Assembly

Jerry Workman

Dept. of Biochemistry and Molecular Biology, Pennsylvania State Univ.

10-30 COFFEE

11-00 Intracellular Localization of mRNAs
Natalie Cohen

Univ. of Southern California

11-45 Sensing Stress and Protein Damage by Heat Shock Transcription Factors and Molecular Chaperones
Rick Morimoto

Dept. of Biochemistry, Molecular Biology and Cell Biology, Northwestern Univ.

12-30 GENERAL DISCUSSION

1-00 LUNCH (Queen’s College Hall)

4-00 - 6-00 POSTER SESSION 2 (College Bar open)

6-00 DINNER

WEDNESDAY PM

Organization and Compartmentation of Glycolysis and Glycogen Metabolism

Discussion Leader: John Wilson

Dept. of Biochemistry, Michigan State Univ.

7-15 Discrete Functions of Hexokinase Isozymes
Chris Newgard
Dept. of Biochemistry, Univ. of Texas Southwestern Medical Center

8-00 Translocation of Glucokinase
Kasim Mookhtiar

Dept. of Metabolic Diseases, Bristol-Myers Squibb Pharmaceutical Research Institute

8-45 Break

8-55 Glycogen Synthesis
Joan Guinovart
Dept. of Biochemistry and Molecular Biology, Univ. of Barcelona

9-40 GENERAL DISCUSSION

THURSDAY SEPT 17th

Breakfast 7-45 - 8-45 Queen’s College Hall

THURSDAY AM

Integrative Biology

Discussion Leader: Rick Welch

Univ. Maryland Baltimore County

9-00 Genome Functional Analysis in the Post-Genomic Era
Steve Oliver
Dept. of Biomolecular Sciences, UMIST

9-45 Hierarchical Control Analysis
Hans Westerhoff

Free Univ., Amsterdam

10-30 COFFEE

11-00 New Approaches to Defining the Flavonoid Metabolon
Brenda Shirley

Dept. of Biology, Virginia Tech Univ.

11-45 Gene Knockouts in Animals

Bé Wieringa

Catholic University of Nijmegen

12-30 GENERAL DISCUSSION

1-00 LUNCH (Queen’s College Hall)

THURSDAY PM

Organization of Signaling Pathways.

Discussion Leader: Susan Jaken,

W. Alton Jones Cell Science Center

2-30 Protein Kinase C: Isozymes, Substrates, and Translocation
Susan Jaken

W. Alton Jones Cell Science Center

3-15 Signal Transduction Pathways that Regulate Neuronal Differentiation, Survival, and Adaptive Responses
Michael Greenberg

Div. of Neurosciences, Children's Hospital, Harvard Univ.

4-00 TEA

4-20 Neuronal Targeting of Kinase Phosphatase Signaling Complexes
John D. Scott
Howard Hughes Medical Institute, Vollum Institute

5-05 GENERAL DISCUSSION

5-30 - 6 pm Business Meeting

6-45 RECEPTION (Queen’s College Quad)

7-30 CONFERENCE BANQUET (Queen’s College Hall)

FRIDAY SEPTEMBER 18th

Breakfast 7-45 - 8-45 Queen’s College Hall

DEPART