This model is the pyruvate pathways for lactococcus lactis used in

B. Jayawardhana, D.B. Kell, M. Rattray, "Bayesian inference of the sites of perturbations in metabolic pathways via Markov chain Monte Carlo", Bioinformatics, vol. 24, no. 9, pp. 1191-1197, 2008. doi: 10.1093/bioinformatics/btn103

Contact detail for the model: bayujw@ieee.org, dbk@manchester.ac.uk, magnus.rattray@cs.man.ac.uk

The model is a modification from the pathways described in

Marcel H.N. Hoefnagel, et.al., "Metabolic engineering of lactic acid bacteria, the combined approach: kinetic modeling, metabolic control and experimental analysis", Microbiology, vol. 148, pp. 1003-1013, 2002.

 substrate Km V V substrate Km substrate Knad_13 Knadh_13 Ko_13 NAD NADH O2 V_13 compartment V_13 NADH O2 compartment Knadh_13 Ko_13 1 NADH compartment Knadh_13 NAD compartment Knad_13 1 O2 compartment Ko_13 ADP ATP Katp_12 V_12 compartment n_12 V_12 ATP compartment ADP compartment Katp_12 n_12 1 ATP compartment ADP compartment Katp_12 n_12 compartment AcetoinIn Butanediol Kacet_11 Kbut_11 Keq_11 Knad_11 Knadh_11 NAD NADH V_11 compartment V_11 AcetoinIn compartment NADH compartment Butanediol compartment NAD compartment Keq_11 Kacet_11 Knadh_11 1 AcetoinIn compartment Kacet_11 Butanediol compartment Kbut_11 1 NADH compartment Knadh_11 NAD compartment Knad_11 compartment AcetoinIn Kacet_10 V_10 compartment V_10 AcetoinIn Kacet_10 1 AcetoinIn compartment Kacet_10 AcLac AcetoinIn Kacet_9 Kaclac_9 V_9 compartment V_9 AcLac Kaclac_9 1 AcLac compartment Kaclac_9 AcetoinIn compartment Kacet_9 AcLac Kaclac_8 Keq_8 Kpyr_8 V_8 compartment n_8 pyruvate V_8 pyruvate Kpyr_8 1 AcLac compartment pyruvate compartment Keq_8 pyruvate compartment Kpyr_8 AcLac compartment Kaclac_8 n_8 1 1 pyruvate compartment Kpyr_8 AcLac compartment Kaclac_8 n_8 AcO EtOH Kaco_7 Keq_7 Ketoh_7 Knad_7 Knadh_7 NAD NADH V_7 compartment V_7 AcO compartment NADH compartment EtOH compartment NAD compartment Keq_7 Kaco_7 Knadh_7 1 NAD compartment Knad_7 NADH compartment Knadh_7 1 AcO compartment Kaco_7 EtOH compartment Ketoh_7 compartment AcCoA AcO CoA Kaccoa_6 Kaco_6 Kcoa_6 Keq_6 Knad_6 Knadh_6 NAD NADH V_6 compartment V_6 AcCoA compartment NADH compartment CoA compartment NAD compartment AcO compartment Keq_6 Kaccoa_6 Knadh_6 1 NAD compartment Knad_6 NADH compartment Knadh_6 1 AcCoA compartment Kaccoa_6 CoA compartment Kcoa_6 AcO compartment Kaco_6 AcO compartment CoA compartment Kaco_6 Kcoa_6 compartment ADP ATP Ac AcP Kac_5 Kacp_5 Kadp_5 Katp_5 Keq_5 V_5 compartment V_5 AcP compartment ADP compartment Ac compartment ATP compartment Keq_5 Kadp_5 Kacp_5 1 AcP compartment Kacp_5 Ac compartment Kac_5 1 ADP compartment Kadp_5 ATP compartment Katp_5 compartment AcCoA AcP CoA Kacp_4 Keq_4 Kiaccoa_4 Kiacp_4 Kicoa_4 Kipi_4 Kpi_4 PO4 V_4 compartment V_4 AcCoA compartment PO4 AcP compartment CoA compartment Keq_4 Kiaccoa_4 Kpi_4 1 AcCoA compartment Kiaccoa_4 PO4 Kipi_4 AcP compartment Kiacp_4 CoA compartment Kicoa_4 AcCoA compartment PO4 Kiaccoa_4 Kpi_4 AcP compartment CoA compartment Kacp_4 Kicoa_4 compartment AcCoA CoA Kaccoa_3 Kcoa_3 Ki_3 Knad_3 Knadh_3 Kpyr_3 NAD NADH V_3 compartment pyruvate V_3 pyruvate Kpyr_3 NAD compartment Knad_3 CoA compartment Kcoa_3 NAD compartment NAD compartment Ki_3 NADH compartment 1 pyruvate compartment Kpyr_3 1 NAD compartment Knad_3 NADH compartment Knadh_3 1 CoA compartment Kcoa_3 AcCoA compartment Kaccoa_3 Keq_2 Klac_2 Knad_2 Knadh_2 Kpyr_2 NAD NADH V_2 compartment lactate pyruvate V_2 pyruvate compartment NADH compartment lactate compartment NAD compartment Keq_2 Kpyr_2 Knadh_2 1 pyruvate compartment Kpyr_2 lactate compartment Klac_2 1 NADH compartment Knadh_2 NAD compartment Knad_2 compartment ADP ATP Kadp_1 Katp_1 Kglc_1 Knad_1 Knadh_1 Kpyr_1 NAD NADH V_1 compartment halfglucose pyruvate V_1 halfglucose Kglc_1 NAD compartment Knad_1 ADP compartment Kadp_1 1 halfglucose compartment Kglc_1 pyruvate compartment Kpyr_1 1 NAD compartment Knad_1 NADH compartment Knadh_1 1 ADP compartment Kadp_1 ATP compartment Katp_1 compartment function_4_R1 ADP ATP Kadp_1 Katp_1 Kglc_1 Knad_1 Knadh_1 Kpyr_1 NAD NADH V_1 compartment halfglucose pyruvate compartment function_4_R2 Keq_2 Klac_2 Knad_2 Knadh_2 Kpyr_2 NAD NADH V_2 compartment lactate pyruvate compartment function_4_R3 AcCoA CoA Kaccoa_3 Kcoa_3 Ki_3 Knad_3 Knadh_3 Kpyr_3 NAD NADH V_3 compartment pyruvate compartment function_4_R4 AcCoA AcP CoA Kacp_4 Keq_4 Kiaccoa_4 Kiacp_4 Kicoa_4 Kipi_4 Kpi_4 PO4 V_4 compartment compartment function_4_R5 ADP ATP Ac AcP Kac_5 Kacp_5 Kadp_5 Katp_5 Keq_5 V_5 compartment compartment function_4_R6 AcCoA AcO CoA Kaccoa_6 Kaco_6 Kcoa_6 Keq_6 Knad_6 Knadh_6 NAD NADH V_6 compartment compartment function_4_R7 AcO EtOH Kaco_7 Keq_7 Ketoh_7 Knad_7 Knadh_7 NAD NADH V_7 compartment compartment function_4_R8 AcLac Kaclac_8 Keq_8 Kpyr_8 V_8 compartment n_8 pyruvate compartment function_4_R9 AcLac AcetoinIn Kacet_9 Kaclac_9 V_9 compartment compartment function_4_R10 AcetoinIn Kacet_10 V_10 compartment compartment function_4_R11 AcetoinIn Butanediol Kacet_11 Kbut_11 Keq_11 Knad_11 Knadh_11 NAD NADH V_11 compartment compartment function_4_R12 ADP ATP Katp_12 V_12 compartment n_12 compartment function_4_R13 Knad_13 Knadh_13 Ko_13 NAD NADH O2 V_13 compartment compartment k1 AcLac compartment function_0 pyruvate Km V