| 2012 |
Funke, C., Schneider, S. A., Berg, D. and Kell, D.B. (2012). Genetics and iron in the systems biology of Parkinson’s disease and some related disorders.
NCI, in press.
doi:10.1016/j.neuint.2012.11.015
Kell, D. B., Dobson, P. D., Bilsland, E. and Oliver, S. G. (2012). The promiscuous binding of pharmaceutical drugs and their transporter-mediated uptake into cells:
what we (need to) know and how we can do so. Drug Discovery Today, in press.
O'Hagan, S., Knowles, J. & Kell, D. B. (2012). Exploiting genomic knowledge in optimising molecular breeding programmes: algorithms from evolutionary computing. PLoS ONE 7, e48862.
Kell, D.B. (2012) Reviews turn facts into understanding. Nature 490, 37.
Dunn, W. B., Brown, M., Worton, S. A., Davies, K., Jones, R. L., Kell, D. B. & Heazell, A. E. P. (2012). The metabolome of human placental tissue: investigation of ?rst trimester tissue and changes related to preeclampsia in late pregnancy. Metabolomics (2012) 8:579–597,
doi:10.1007/s11306-011-0348-6
Lee, D., Smallbone, K., Dunn, W. B., Murabito, E., Winder, C. L., Kell, D. B., Mendes, P. & Swainston, N. (2012). Improving metabolic flux predictions using absolute gene expression data. BMC Systems Biology 6, 73.
Miwa, M., Thompson, P., McNaught, J., Kell, D.B. & Ananiadou, S. (2012) Extracting semantically enriched events from biomedical literature. BMC Bioinformatics 2012, 13:108.
Dikicioglu, D., Dunn, W. B., Kell, D. B., Kirdar, B. & Oliver, S. G. (2012). Short- and long-term dynamic responses of the metabolic network and gene expression in yeast to a transient change in the nutrient environment. Mol BioSyst 8, 1760-1774.
Kell D.B. (2012) Large-scale sequestration of carbon via plant roots in natural and agricultural ecosystems: why and how. Phil Trans R Soc 367, 1589-1597.
Davey, H. M., Cross, E. J. M., Davey, C. L., Gkargkas, K., Delneri, D., Hoyle, D. C., Oliver, S. G., Kell, D. B. & Griffith, G. W. (2012). Genome-wide analysis of longevity in nutrient-deprived Saccharomyces cerevisiae reveals the importance of recycling in maintaining cell viability. Env Microbiol, in press.
Wang, Y., Paszek, P., Horton, C. A., Yue H., White M. R. H., Kell D. B., Muldoon M. R. & Broomhead D. S. (2012). A systematic survey of the response of a model NF-κB signalling
pathway to TNFα stimulation. J. Theoret. Biol., 297, 137-147.
Kell, D.B. (2012). Scientific discovery as a combinatorial optimisation problem: How best to navigate the
landscape of possible experiments? BioEssays (online early view).
Pir, P., Gutteridge, A., Wu, J., Rash, B., Kell, D. B., Zhang, N. & Oliver, S. G. (2012). The genetic control of growth rate: a systems biology study in yeast. BMC Sys Bio 6:4
|
| 2011 |
Swainston, N., Smallbone, K., Mendes, P., Kell, D. B. & Paton, N. W.
(2011). The SuBliMinaL Toolbox: automating steps in the reconstruction of metabolic networks. Integrative Bioinf 8, 186.
Courtot, M., Juty, N., Knupfer, C., Waltemath, D., Zhukova, A., Drager, A., Dumontier, M., Finney, A., Golebiewski, M., Hastings, J., Hoops, S., Keating, S., Kell, D. B., Kerrien, S., Lawson, J., Lister, A., Lu, J., Machne, R., Mendes, P., Pocock, M., Rodriguez, N., Villeger, A., Wilkinson, D. J., Wimalaratne, S., Laibe, C., Hucka, M. and Le Novere, N. (2011). Controlled vocabularies and semantics in systems biology. Mol Syst Biol 7:543
doi:10.1038/msb.2011.77
Small, B. G., McColl, B. W., Allmendinger, R., Pahle, J., López-Castejón, G., Rothwell, N. J., Knowles, J., Mendes, P., Brough, D., and Kell, D. B. (2011). Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing. Nature Chemical Biology (2011)
doi:10.1038/nchembio.689
Lanthaler, K., Bilsland, E., Dobson, P. D., Moss, H. J., Pir, P., Kell, D. B., and Oliver, S. G. (2011). Genome-wide assessment of the carriers involved in the cellular uptake of drugs: a model system in yeast. BMC Biology 2011, 9:70
Carroll, K. M., Simpson, D. M., Eyers, C. E., Knight, C. G., Brownridge, P., Dunn, W., Winder, C. L., Lanthaler, K., Pir, P., Malys, N., Kell, D.B., Oliver, S. G., Gaskell, S. J. & Beynon, R. J. (2011). Absolute quantification of the glycolytic pathway in yeast: deployment of a complete QconCAT approach.Mol Cell Proteomics 10, M111 007633.
Horgan, R. P., Broadhurst, D. I., Walsh, S. K., Dunn, W. B., Brown, M., Roberts, C., North, R. A., McCowan, L., Kell, D. B., Baker, P. N. & Kenny, L. C. (2011). Metabolic profiling uncovers a phenotypic signature of Small for Gestational Age in early pregnancy. J Proteome Res 10, 3660-3673.
Kell DB. Carbon dioxide - an age-old problem. FST Journal 2011; 20:22-23.
Kell DB. (2011). Breeding crop plants with deep roots: their role in sustainable carbon, nutrient and water sequestration. Annals of Botany. doi:10.1093/aob/mcr175
Kell DB, Dobson PD, Oliver SG (2011). Pharmaceutical drug transport: the issues and the implications that it is essentially carrier-mediated only. Drug Discovery Today. (2011) 16:15-16 704-714. doi:10.1016/j.drudis.2011.05.010
Dunn WB, Broadhurst D, Begley P, Zelena E, Francis-McIntyre S, Anderson N, Brown N, Knowles J, Halsall A, Haselden JN, Nicholls A, Wilson ID, Kell DB, Goodacre R and The Husermet consortium (2011). Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry. Nature Protocols 6:1060-1083.
Flavell, R., de Brito Cruz, C. H., Christie, M., Allen, J., Keller, M., Gilna, P. & Kell, D. B. (2011). Moving forward with biofuels. Nature Outlook Biofuels 474, S44-S48.
Brown, M., Wedge, D., Goodacre, R., Kell, D. B., Baker, P. N., Kenny, L. C., Mamas, M. A., Neyses, L. & Dunn, W. B. (2011). Automated workflows for accurate mass-based putative metabolite identification in LC/MS-derived metabolomic datasets. Bioinformatics 27, 1108-1112.
Nobata, C., Dobson, P., Iqbal, S. A., Mendes, P., Tsujii, J. i., Kell, D. B. & Ananiadou, S. (2011). Mining metabolites: extracting the yeast metabolome from the literature. Metabolomics 7, 94-101.
Patel, Y., Heyward, C. A., White, M. R. H. & Kell, D. B. (2011). Predicting the points of interaction of small molecules in the NF-kappaB pathway. BMC Systems Biology 5, 32.
Kell DB: Understanding the languages of cells. Network modelling in metabolic systems biology and biotechnology: why, how and whither. The Biochemist 2011; 33:4-7.
Wang, Y., Paszek, P., Horton, C. A., Kell, D. B., White, M. R. H., Broomhead, D. S. and Muldoon, M. R. (2011), Interactions among oscillatory pathways in NF- kappa B signalling., BMC Systems Biology 2011, 5:23 DOI:10.1186/1752-0509-5-23 (online version)
Kell D.B.: Metabolites do social networking. Nat Chem Biol 2011; 7:7-8.
|
| 2010 |
Li P, Dada JO, Jameson D, Spasic I, Swainston N, Carroll K, Dunn W, Khan F, Messiha HL, Simeonidis E, Weichart D, Winder C, Broomhead DS, Goble CA, Gaskell SJ, Kell DB, Westerhoff HV, Mendes P, Paton NW: Systematic integration of experimental data and models in systems biology. BMC Bioinformatics 2010; 11:582. (Online version).
Kell, D. B. (2010). Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examples. Arch Toxicol 577, 825-889. (Online version here)
Dobson, P. D., Smallbone, K., Jameson, D., Simeonidis, E., Lanthaler, K., Pir, P., Lu, C., Swainston, N., Dunn, W. B., Fisher, P., Hull, D., Brown, M., Oshota, O., Stanford, N. J., Kell, D. B., King, R. D., Oliver, S. G., Stevens, R. D. & Mendes, P. (2010). Further developments towards a genome-scale metabolic model of yeast. BMC Systems Biology 4, 145.
Horgan RP, Broadhurst DI, Dunn WB, Brown MC, Heazell AE, Kell DB, Baker PN, Kenny LC: Changes in the metabolic footprint of placental villous explants cultured in different oxygen tensions from placentas of Small for Gestational Age and normal pregnancies. Placenta 2010; 31:893-901.
Rowe W, Wedge DC, Platt M, Kell DB, Knowles J: Predictive models for population performance on real biological fitness landscapes. Bioinformatics 2010; 26:45-52.
Attwood TK, Kell DB, McDermott P, Marsh J, Pettifer S, Thorne D: Utopia Documents: linking scholarly literature with research data. Bioinformatics 2010; 26:i568-574.
Swainston N, Golebiewski M, Messiha H, Malys N, Kania R, Kengne S, Krebs O, Mir S, Sauer-Danzwith H, Smallbone K, Weidemann A, Wittig U, Kell D, Mendes P, Müller W, Paton N, Rojas I: Enzyme kinetics informatics: from instrument to browser. FEBS J 2010; 277:3769–3779.
Kenny LC, Broadhurst DI, Dunn W, Brown M, Francis-McIntyre S, North RA, McGowan L, Roberts C, Cooper GJS, Kell DB, Philip N Baker on behalf of the SCOPE consortium: Robust early pregnancy prediction of later preeclampsia using metabolomic biomarkers. Hypertension 2010; 56:741-749.
Kell, D. B. (2010). Systems microbiology. Microbiol Today 37, 14-15.
Rowe, W., Platt, M., Wedge, D. C., Day, P. J. R., Kell, D. B. & Knowles, J. D. (2010). Convergent evolution to an aptamer observed in small populations on DNA microarrays. Phys Biol 7, 036007.
Ananiadou, S., Pyysalo, S., Tsujii, J. i. & Kell, D. B. (2010). Event extraction for systems biology by text mining the literature. Trends Biotechnol 2010; 28:381-390.
Villéger, A. C., Pettifer, S. R. & Kell, D. B. (2010). Arcadia: a visualization tool for metabolic pathways. Bioinformatics 20, 1470-1.
Rowe, W., Platt, M., Wedge, D., Day, P. J., Kell, D. B. & Knowles, J. (2010). Analysis of a complete DNA-protein affinity landscape. J R Soc Interface 7, 397-408. (Supplementary data)
|
| 2009 |
Wedge, D. C., Das, A., Dost, R., Kettle, J., Madec, M.-B., Morrison, J.
J., Grell, M., Kell, D. B., Richardson, T. H., Yeates, S. & Turner,
M. L. (2009). Real-time vapour
sensing using an OFET - based electronic
nose and genetic programming. Sens Act B 143, 365-372.
Attwood, T. K., Kell, D. B., McDermott, P., Marsh, J., Pettifer, S. R.
& Thorne, D. (2009). Calling
International Rescue: knowledge lost in literature and data landslide! Biochem J. 424, 317-333. See also: Get
Utopia Software.
Dunn, W. B., Brown, M., Worton , S. A., Crocker, I. P., Broadhurst, D.,
Horgan, R., Kenny, L. C., Baker, P. N., Kell, D. B. & Heazell, A.
E. P. (2009). Changes in the
metabolic footprint of placental explant-conditioned culture medium
identifies metabolic disturbances related to hypoxia and pre-eclampsia.
Placenta 37, 974-980.
Kell DB: The importance of
mathematics in systems biology. Mathematics Today 2009; August
issue:167-172.
Williamson, T., Schwartz, J.-M., Kell, D. B. & Stateva, L. (2009). Deterministic mathematical models
of the cAMP pathway in Saccharomyces cerevisiae. BMC Systems
Biology 3, 70.
Handley, C. M., Hawe, G. I., Kell, D. B. & Popelier, P. L. A.
(2009). Optimal construction of a
fast and accurate polarisable water potential based on multipole
moments trained by machine learning. Phys Chem Chem Phys 11,
6365-6376.
Begley, P., Francis-McIntyre, S., Dunn, W. B., Broadhurst, D. I.,
Halsall, A., Tseng, A., Knowles, J., HUSERMET consortium, Goodacre, R.
& Kell, D. B. (2009). Development
and performance of a gas chromatography-time-of-flight mass
spectrometry analysis for large-scale non-targeted metabolomic studies
of human serum. Anal Chem 81, 7038-7046.
Le Novère, N., Hucka, M., Mi, H., Moodie, S., Schreiber, F., Sorokin,
A., Demir, E., Wegner, K., Aladjem, M., Wimalaratne, S. M., Bergman, F.
T., Gauges, R., Ghazal, P., Hideya, K., Li, L., Matsuoka, Y., Villéger,
A., Boyd, S. E., Calzone, L., Courtot, M., Dogrusoz, U., Freeman, T.,
Funahashi, A., Ghosh, S., Jouraku, A., Kim, S., Kolpakov, F., Luna, A.,
Sahle, S., Schmidt, E., Watterson, S., Wu, G., Goryanin, I., Kell, D.
B., Sander, C., Sauro, H., Snoep, J. L., Kohn, K. & Kitano, H.
(2009). The systems biology
graphical notation. Nat Biotechnol 27, 735-741. Supplementary
information.
Kell, D. B. (2009). Journal
Club: A systems biologist ponders how disparate ideas can sometimes
come together beautifully. Nature 460, 669.
Kell, D. B. (2009). Correspondence - Dormant microbes:
time to revive some old ideas, Nature 458, 831.
Jameson, D., Turner, D. A., Ankers, J., Kennedy, S., Ryan, S.,
Swainston, N., Griffiths, T., Spiller, D. G., Oliver, S. G., White, M.
R. H., Kell, D. B. & Paton, N. W. (2009). Information management for high
content live cell imaging. BMC Bioinformatics 10, 226.
Platt, M., Rowe, W., Wedge, D. C., Kell, D. B., Knowles, J. &
Day, P. J. R. (2009). Aptamer
evolution for array-based
diagnostics. Anal Biochem, 390, 203-205.
Brown, M., Dunn, W. B., Dobson, P., Patel, Y., Winder, C. L.,
Francis-McIntyre, S., Begley, P., Carroll, K., Broadhurst, D., Tseng,
A., Swainston, N., Spasic, I., Goodacre, R. & Kell, D. B. (2009). Mass spectrometry tools and
metabolite-specific databases for molecular identification in
metabolomics. Analyst 134, 1322-1332.
Pettifer, S. R., Thorne, D., McDermott, P., Marsh, J., Villéger, A.,
Kell, D. B. & Attwood, T. K. (2009). Visualising biological
data: a semantic approach to tool and database integration. BMC
Bioinformatics 10, S19.
Spasić, I., Simeonidis, E., Messiha, H. L., Paton, N. W.
&
Kell, D. B. (2009). KiPar,
a
tool for systematic information retrieval regarding parameters for
kinetic modelling of yeast metabolic pathways. Bioinformatics
25, 1404-1411.
Kell, D. B. (2009). Iron
behaving badly:
inappropriate iron chelation as a major contributor to the
aetiology of vascular and other progressive inflammatory and
degenerative diseases. BMC Medical Genomics 2, 2 -
doi:10.1186/1755-8794-2-2 See BMC Medical Genomics: Most accessed
articles of the past
year, and of all
time.
Ashall, L., Horton, C. A., Nelson, D. E., Paszek, P., Ryan, S.,
Sillitoe, K., Harper, C. V., Spiller, D. G., Unitt, J. F.,
Broomhead, D. S., Kell, D. B., Rand, D., Sée, V. &
White,
M. R. H. (2009). Pulsatile
stimulation determines timing and specificity of
NF-κ-B-dependent transcription. Science 324,
242-246. Supplementary
Information
Das, A., Dost, R., Richardson, T. H., Grell, M., Wedge, D. C.,
Kell, D. B., Morrison, J. J. & Turner, M. L. (2009). Low
cost,
portable,fast multiparameter data acquisition system for organic
transistor odour sensors. Sens. Act. B 137, 586-591
Kell, D. B. & Dobson, P. D. (2009). The
cellular uptake of pharmaceutical drugs is mainly carrier-mediated
and is thus an issue not so much of biophysics but of systems
biology. In Systems Chemistry, pp. 149-168. Beilstein
Institute, Frankfurt
Dobson, P., Lanthaler, K., Oliver, S. G. & Kell, D. B. (2009). Implications
of the dominant role of cellular transporters in drug uptake.
Curr Top Med Chem 9, 163-184
Platt, M., Rowe, W., Knowles, J., Day, P. J. & Kell, D. B.
(2009). Analysis
of
aptamer sequence-activity relationships. Integr Biol 1,
116-122. DOI: 10.1039/b814892a.
Zelena, E., Dunn, W., Broadhurst, D., Francis-McIntyre, S.,
Carroll, K., Begley, P., O'Hagan, S., Knowles, J. D., Halsall, A.,
HUSERMET Consortium, Wilson, I. & Kell, D.B. (2009). Development
of a
robust and repeatable UPLC-MS method for the long-term metabolomic
study of human serum. Anal Chem 81, 1357-1364
Wedge, D., Rowe, W., Kell, D. B. & Knowles, J. (2009). In
silico modelling of directed evolution: implications for experimental
design and stepwise evolution. J Theor Biol, 2009, 131-141
Knight, C.G., Platt, M., Rowe, W., Wedge, D.C., Khan, F., Day,
P.J.R., McShea, A., Knowles, J. and Kell, D.B. (2009). Array-based
evolution of DNA aptamers allows modelling of an explicit
sequence-fitness landscape. Nucleic
Acids Research, 2009, Vol. 37, No. 1 e6 (Supplementary info: 1, 2, 3 & 4 Data: Training Data; Test Sequence Data; Readme.txt)
Dobson, P. D., Patel, Y. & Kell, D. B. (2009). "Metabolite-likeness"
as a criterion in the design and selection of pharmaceutical drug
libraries. Drug Disc Today, 14, 31-40
|
| 2008 |
Kell, D. B. (2008). Progress
being
made on standards for use in data sharing. Nature 456, 29
Hull, D., Pettifer, S. R. & Kell, D. B. (2008). Defrosting
the digital library: bibliographic tools for the next generation
web. PLoS Comput Biol 4, e1000204. doi:10.1371/journal.pcbi.1000204.
Dobson, P. D. & Kell, D. B. (2008). Carrier-mediated cellular uptake of pharmaceutical drugs: an
exception or the rule? Nat Rev Drug Discov, 7,
205-220. Supplementary
Information. Link
to
journal.
. (Request
Reprint)
Wedge, D. & Kell, D. B. (2008). Rapid
prediction of optimum population size in genetic programming using
a novel genotype - fitness correlation. GECCO 2008 (M. Keizer
et al., eds), 1315-1322. (Nominated for best paper.)
Farrelly, C., Kell, D. B. & Knowles, J. (2008). Predicting
molecular structure using ant colony optimization: a preliminary
study. LNCS 5217, 120-131
Herrgård, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga,
K. Y., Arvas, M., Blüthgen, N., Borger, S., Costenoble, R.,
Heinemann, M., Hucka, M., Le Novère, N., Li, P.,
Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D.,
Pettifer, S., Simeonidis, E., Smallbone, K., Spasić, I.,
Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V.,
Kirdar, B., Penttilä, M., Klipp, E., Palsson, B. Ø.,
Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J. & Kell, D. B.
(2008). A
consensus yeast metabolic network obtained from a community
approach to systems biology. Nature Biotechnol. 26,
1155-1160
Yisu, J., Knowles, J., Hongmei, L., Yizeng, L. & Kell, D. B.
(2008). The
landscape adaptive particle swarm optimizer. Applied Soft
Computing J 8, 295-304
Yue, H., Brown, M., He, F., Jia, J. & Kell, D. B. (2008). Sensitivity
analysis and robust experimental design of a signal transduction
pathway system. Int J Chem Kinet 40, 730-741
Heazell, A. E. P., Brown, M., Dunn, W. B., Worton, S. A., Crocker,
I. P., Baker, P. N. & Kell, D. B. (2008). Analysis
of
the metabolic footprint and tissue metabolome of placental villous
explants cultured at different oxygen tensions reveals novel redox
biomarkers. Placenta 29, 691-698
Dunn, W. B., Broadhurst, D., Brown, M., Baker, P. N., Redman, C. W.
G., Kenny, L. C. & Kell, D. B. (2008). Metabolic
profiling of mammalian serum using Ultra Performance Liquid
Chromatography and the LTQ-Orbitrap mass spectrometry system. J
Chromatogr B, 871, 288-298
Li, P., Castrillo, J. I., Velarde, G., Wassink, I., Soiland-Reyes,
S., Owen, S., Withers, D., Oinn, T., Pocock, M. R., Goble, C. A.,
Oliver, S. G. & Kell, D. B. (2008). Performing
statistical analyses on quantitative data in Taverna workflows: an
example using R and maxdBrowse to identify differentially expressed
genes from microarray data. BMC Bioinformatics 9, 334
Kell, D. B. (2008). Iron
behaving badly: inappropriate iron chelation as a major contributor
to the aetiology of vascular and other progressive inflammatory and
degenerative diseases. Preprint (159pp):http://arxiv.org/abs/0808.1371
Kenny, L. C., Broadhurst, D., Brown, M., Dunn, W. B., Redman, C.
W., Kell, D. B. & Baker, P. N. (2008). Detection
and
identification of novel metabolomic biomarkers in preeclampsia. Reprod Sci 15, 591-7
Kell, D. B. & Mendes, P. (2008). The markup is the model: reasoning about systems biology models in
the Semantic Web era. J Theoret Biol, 252, 538-543
Spasić, I., Schober, D., Sansone, S., Rebholz-Schuhmann, D.,
Kell, D.B. & Paton, N.W. (2008) Facilitating
the
development of controlled vocabularies for metabolomics
technologies with text mining. BMC Bioinformatics, 9, S5
Lu, H., Dunn, W. B., Shen, H., Kell, D. B. & Liang, Y. (2008). Comparative
evaluation of software for deconvolution of metabolomics data based
on GC-TOF-MS. Trends Anal Chem 27, 215-227
Dunn, W. B., Broadhurst, D., Ellis, D. I., Brown, M., Ashworth, J.,
Cameron, M., Halsall, A., O'Hagan, S., Spasić, I., Tseng, A.
& Kell, D. B. (2008). A
GC-TOF-MS
study of the stability of serum and urine metabolomes during the UK
Biobank sample collection and preparation protocols. Int J
Epidemiol 2007, 1-8
Jayawardhana, B., Kell, D.B. & Rattray, M. (2008) Bayesian inference of the sites of perturbations in metabolic
pathways via Markov Chain Monte Carlo. Bioinformatics, doi:
10.1093/bioinformatics/btn1103
Peiris, D., Dunn, W. B., Brown, M., Kell, D. B., Roy, I. &
Hedger, J. N. (2008). Metabolite
profiles of interacting mycelial fronts differ for pairings of the
wood decay basidiomycete fungus Stereum hirsutum with its
competitors Coprinus micaceus and Coprinus disseminatus. Metabolomics 4, 52-62
Li, P., Oinn, T., Stoiland, S. & Kell, D. B. (2008). Automated
manipulation of systems biology models using libSBML within Taverna
workflows. Bioinformatics 24, 287-289
Delneri, D., Hoyle, D. C., Gkargkas, K., Cross, E. J., Rash, B.,
Zeef, L., Leong, H. S., Davey, H. M., Hayes, A., Kell, D. B.,
Griffith, G. W. & Oliver, S. G. (2008). Identification
and
characterization of high-flux-control genes of yeast through
competition analyses in continuous cultures. Nat Genet 40,
113-7
Wilkinson, S. J., Benson, N. & Kell, D. B. (2008). Proximate
parameter tuning for biochemical networks with uncertain kinetic
parameters. Mol Biosyst, 10.1039/b707506e. Enhanced HTML at RSC.
Lüdtke, N., Panzeri, S., Brown, M., Broomhead, D. S., Knowles,
J., Montemurro, M. A. & Kell, D. B. (2008). Information-theoretic
Sensitivity Analysis: a general method for credit assignment in
complex networks. J Roy Soc Interface 5, 223-235
|
| 2007 |
Dunn, W. B., Broadhurst, D. I., Sasalu, D., Buch, M., McDowell, G.,
Spasić, I., Ellis, D. I., Brooks, N., Kell, D. B. &
Neyses, L. (2007). Serum
metabolomics reveals many novel metabolic markers of heart failure,
including pseudouridine and 2-oxoglutarate. Metabolomics 3,
413-426. Supplementary
information
Smallbone, K., Simeonidis, E., Broomhead, D. S. & Kell, D. B.
(2007). Something
from nothing: bridging the gap between constraint-based and kinetic
modelling. FEBS J 274, 5576-5585
Kell, D. B. (2007). The
virtual human: towards a global systems biology of multiscale,
distributed biochemical network models. IUBMB Life 59,
689-95
Goodacre, R., Broadhurst, D., Smilde, A., Kristal, B. S., Baker, J.
D., Beger, R., Bessant, C., Connor, S., Capuani, G., Craig, A.,
Ebbels, T., Kell, D. B., Manetti, C., Newton, J., Paternostro, G.,
Somorjai, R.,
Sjöström, M.,
Trygg, J. & Wulfert, F. (2007). Proposed
minimum reporting standards for data analysis in metabolomics.
Metabolomics 3, 231-241
Pope, G. A., MacKenzie, D. A., Defemez, M., Aroso, M., Fuller, L.
J., Mellon, F. A., Dunn, W. B., Brown, M., Goodacre, R., Kell, D.
B., Marvin, M. E., Louis, E. J. & Roberts, I. N. (2007). Metabolic
footprinting as a tool for discriminating between brewing
yeasts. Yeast 24, 667-679.
Yisu, J., Knowles, J., Hongmei, L., Yizeng, L. & Kell, D. B.
(2007).The
landscape adaptive particle swarm optimizer. Applied Soft
Computing J 8, 295-304.
Kell, D. B. (2007).Metabolomic
biomarkers: search, discovery and validation. Exp Rev Mol
Diagnost 7, 329-333.
Wedge, D., Gaskell, S. J., Hubbard, S., Kell, D. B., Lau, K. W.
& Eyers, C. (2007). Peptide
detectability following ESI mass spectrometry: prediction using
genetic programming. In GECCO
2007 (ed. D. Thierens et al.), pp. 2219-2225. ACM,
New York.
Handl, J., Kell, D. B. & Knowles, J. (2007). Multiobjective
optimization in bioinformatics and computational biology.
IEEE
Trans Comput Biol Bioinformatics 4, 279-292.
Westerhoff, H. V. & Kell, D. B. (2007). The methodologies of systems biology. In Systems biology:
philosophical foundations (ed. F. C. Boogerd, F. J. Bruggeman,
J.-H. S. Hofmeyr and H. V. Westerhoff), pp. 23-70. Elsevier,
Amsterdam.
Castrillo, J. I., Zeef, L. A., Hoyle, D. C., Zhang, N., Hayes, A.,
Gardner, D. C. J., Cornell, M. J., Petty, J., Hakes, L.,
Wardleworth, L., Rash, B., Brown, M., Dunn, W. B., Broadhurst, D.,
O'Donoghue, K., Hester, S. S., Dunkley, T. P. J., Hart, S. R.,
Swainston, N., Li, P., Gaskell, S. J., Paton, N. W., Lilley, K. S.,
Kell, D. B. & Oliver, S. G. (2007). Growth
control of the eukaryote cell: a systems biology study in
yeast. J. Biol 6, 4. See also commentary.
Oinn, T., Li, P., Kell, D. B., Goble, C., Goderis, A., Greenwood,
M., Hull, D., Stevens, R., Turi, D. & Zhao, J. (2007). Taverna
/myGrid: aligning a workflow system with the
life
sciences community. In Workflows for e-Science:
scientific
workflows for Grids (ed. I. J. Taylor, E. Deelman, D. B.
Gannon
and M. Shields), pp. 300-319. Springer, Guildford
O'Hagan, S., Dunn, W. B., Broadhurst, D., Williams, R., Ashworth,
J. A., Cameron, M., Knowles, J. & Kell, D. B. (2007). Closed-loop, multi-objective optimisation of two-dimensional gas
chromatography (GCxGC-tof-MS) for serum metabolomics. Anal
Chem
79, 464-476
|
| 2006 |
Broadhurst, D.
& Kell, D. B. (2006). Statistical strategies for avoiding false discoveries in
metabolomics and related experiments. Metabolomics 2,
171-196;
DOI: 10.1007/s11306-006-0037-z
Ananiadou, S.,
Kell, D. B. & Tsujii, J.-i. (2006). Text
Mining
and its potential applications in Systems Biology. T rends
Biotechnol 24, 571-579
Kell, D.B. (2006) Systems
biology,
metabolic modelling and metabolomics in drug discovery and
development Drug Discovery Today, 11, 1085-1092.
Shen, H., Nelson, G., Nelson, D.E., Kennedy, S., Spiller, D.G.,
Griffiths, T., Paton, N., Oliver, S.G., White, M.R.H., Kell, D.B.
(2006) Automated
tracking of
gene expression in individual cells and cell compartments Journal of the Royal Society Interface, 3, 787-794. [web site]
Yue, H., Brown, M., Knowles, J., Wang, H., Broomhead, D.S. &
Kell, D.B. (2006) Insights
into the behaviour
of systems biology models from dynamic sensitivity and
identifiability analysis: a case study of an NF-κ
-B signalling pathway. Molecular
BioSystems,
2, 640-649.
Spasic, I., Dunn, W., Velarde, G., Tseng, A., Jenkins, H., Hardy,
N.W., Oliver, S.G. & Kell, D.B. (2006) MeMo:
a hybrid SQL/XML approach to
metabolomic
data management for functional genomics. BMC Bioinformatics,
7,
281. [web site]
Shen, H., Nelson, G., Kennedy, S., Nelson, D., Johnson, J.,
Spiller, D., White, M.R.H. & Kell, D.B. (2006) Automatic tracking of
biological cells
and compartments using particle filters and active contours.
Chemometrics and Intelligent Laboratory Systems 82, 276 282.
[web site]
Underwood, B.R., Broadhurst, D., Dunn, W.B., Ellis, D.I., Michell,
A.W., Vacher, C., Mosedale, D.E., Kell, D.B., Barker, R., Grainger,
D.J. & Rubinsztein, D.C. (2006) Huntington
disease patients and transgenic mice
have similar pro-catabolic serum metabolite profiles. Brain
129, 877-886.
Kell, D.B. & Knowles, J.D. (2006) The role of
modeling in
systems biology. In System modeling in cellular biology: from
concepts to nuts and bolts (ed. Z. Szallasi, J. Stelling and V.
Periwal), pp. 3-18. MIT Press, Cambridge.
Kell, D.B. (2006) Metabolomics,
modelling and
machine learning in systems biology towards an understanding of the
languages of cells. The
2005 Theodor
Bcher
lecture. The FEBS Journal 273, 873-894.
Mukamolova, G.V., Murzin, A.G., Salina, E.G., Demina, G.R., Kell,
D.B., Kaprelyants, A.S. & Young, M. (2006) Muralytic activity
of
Micrococcus luteus Rpf and its relationship to physiological
activity in promoting bacterial growth and resuscitation.
Molecular Microbiology 59, 84-98.
|
|
| 2005 |
Kenny, L.C., Dunn, W.B., Ellis, D.I., Myers, J., Baker, P.N., The
GOPEC Consortium & Kell, D.B. (2005). Novel
biomarkers for
pre-eclampsia detected using metabolomics and machine learning.
Metabolomics, 1(3), 227-234. DOI: 10.1007/s11306-005-0003-1.
Ihekwaba, A.E.C., Broomhead, D.S., Grimley, R., Benson, N., White,
M.R.H. & Kell, D.B. (2005). Synergistic
control
of oscillations in the NF-κB signalling pathway. IEE
Systems Biology, 152, 153-160.
Vaidyanathan, S., Jones, D., Broadhurst, D.I., Ellis, J., Jenkins,
T., Dunn, W.B., Hayes, A., Burton, N., Oliver, S.G., Kell, D.B.
& Goodacre, R. (2005). A
laser
desorption ionisation mass spectrometry approach for high
throughput metabolomics. Metabolomics, 1(3), 243-250. DOI:
10.1007/s11306-005-0007-x.
Hancock, D., Wilson, M., Velarde, G., Morrison, N., Hayes, A.,
Hulme, H., Wood, A.J., Nashar, K., Kell, D.B. & Brass, A.
(2005) maxdLoad2
and
maxdBrowse:standards-compliant tools for microarray experimental
annotation, data management and dissemination. BMC
Bioinformatics, 6, 264.
Catchpole, G.S., Beckmann, M., Enot, D.P., Mondhe, M., Zywicki, B.,
Taylor, J., Hardy, N., Smith, A., King, R.D., Kell, D.B., Fiehn, O.
& Draper, J. (2005) Hierarchical
metabolomics demonstrates substantial compositional similarity
between genetically modified and conventional potato crops.
Proc Natl Acad Sci U S A 102, 14458-62.
Handl, J., Knowles, J. & Kell, D.B. (2005) Computational cluster validation in post-genomic data analysis.
Bioinformatics, 21, 3201-3212.
Kell, D.B., Brown, M., Davey, H.M., Dunn, W.B., Spasić, I.
& Oliver, S.G. (2005) Metabolic
footprinting
and systems
biology: the medium is the message. Nat Rev Microbiol, 3,
557-565.
Kell, D.B. (2005) Metabolomics,
machine
learning and modelling: towards an understanding of the language of
cells. Biochem Soc Trans 33, 520-524.
Pritchard, L., Corne, D., Kell, D.B., Rowland, J. & Winson, M.
(2005) A
general model of error-prone PCR. Journal of Theoretical
Biology 234, 497509.
Johnson, H.E., Merry, R.J., Davies, D.R., Kell, D.B., Theodorou,
M.K. & Griffith, G.W. (2005) Vacuum packing: a
model
system for laboratory-scale silage fermentations. J Appl
Microbiol 98, 106-113.
Brown, M., Dunn, W.B., Ellis, D.I., Goodacre, R., Handl, J.,
Knowles, J.D., O'Hagan, S., Spasić, I. & Kell, D.B.
(2005) A
metabolome pipeline:
from concept to data to knowledge. Metabolomics 1(1),
39-51.
O'Hagan, S., Dunn, W.B., Brown, M., Knowles, J.D. & Kell, D.B.
(2005) Closed-loop,
multiobjective optimization of analytical instrumentation: gas
chromatography/time-of-flight mass spectrometry of the metabolomes
of human serum and of yeast fermentations. Anal. Chem 77,
290-303. |
|
| 2004 |
Jenkins, H., Hardy, N., Beckmann, M.,
Draper, J., Smith, A.R.,
Taylor, J., Fiehn, O., Goodacre, R., Bino, R.J., Hall, R., Kopka,
J., Lane, G.A., Lange, B.M., Liu, J.R., Mendes, P., Nikolau, B.J.,
Oliver, S.G., Paton, N.W., Rhee, S., Roessner-Tunali, U., Saito,
K., Smedsgaard, J., Sumner, L.W., Wang, T., Walsh, S., Syrkin
Wurtele, E. & Kell, D.B. (2004) A proposed framework
for the
description of plant metabolomics experiments and their
results. Nature Biotechnol. 22(12), 1601-1606.
Ihekwaba, A., Broomhead, D.S., Grimley, R., Benson, N. & Kell,
D.B. (2004) Sensitivity
analysis of
parameters controlling oscillatory signalling in the NF-κB
pathway:
the roles of IKK and IkBa. Systems Biology 1, 93-103.
Zhao, H., Kassama, Y., Young, M., Kell, D.B. & Goodacre, R.
(2004) Differentiation
of
Micromonospora isolates from a coastal sediment in Wales based on
Fourier transform infrared spectroscopy, 16S rDNA sequence
analysis, and the amplified fragment length polymorphism
technique. Appl. Env. Microbiol. 70, 6619-8827.
Nelson, D. E., Ihekwaba, A. E. C., Elliott, M. , Johnson, J. R.,
Gibney, C. A., Foreman, B. E., Nelson, G., See, V., Horton, C. A.,
Spiller, D. G., Edwards, S. W., McDowell, H. P., Unitt, J. F.,
Sullivan, E., Grimley, R., Benson, N., Broomhead, D., Kell, D. B.
& White, M. R. H. (2004) Oscillations
in NF-B
Signaling
Control the Dynamics of Gene Expression. Science 306,
704-708.
Allen, J., Davey, H.M., Broadhurst, D., Rowland, J.J., Oliver, S.G.
& Kell, D.B. (2004) Discrimination
of modes of action of antifungal substances by use of metabolic
footprinting. Applied and Environmental Microbiology 70(10),
61576165.
Vaidyanathan, S., Kell, D.B. & Goodacre, R. (2004) Selective
detection of proteins in mixtures using electrospray ionization
mass spectrometry: influence of instrumental settings and
implications for proteomics. Anal. Chem. 76, 5024-5032.
Kell, D. B., Woodward, A. M., Davies, E. A., Todd, R. W., Evans, M.
F., Rowland, J. J. (2004) Nonlinear
dielectric spectroscopy of biological systems: principles and
applications. Nonlinear Phenomena in Complex Liquids, Kluwer
Academic Publishers, 335-344.
Kell, D. B. (2004) Metabolomics
and
systems biology: making sense of the soup. Current Opinion in
Microbiology 7(3), 296-307.
Woodward, A. M., Rowland, J. J. & Kell, D. B. (2004) Fast automatic
registration of
images using the phase of a complex wavelet transform: application
to proteome gels. Analyst 129, 542-552.
White, T. A. & Kell, D. B. (2004) Comparative
genomic assessment of novel broad-spectrum targets for
antibacterial drugs. Comp. Func. Genomics 5, 304-327.
Goodacre, R., Vaidyanathan, S., Dunn, W.B., Harrigan, G.G. &
Kell, D.B. (2004) Metabolomics
by numbers: acquiring and understanding global metabolite data.
Trends. Biotechnol. 22, 245-252.
Johnson, H.E., Broadhurst, D., Kell, D.B., Theodorou, M.K., Merry,
R.J. & Griffith, G.W. (2004) High-Throughput
Metabolic Fingerprinting of Legume Silage Fermentations via Fourier
Transform Infrared Spectroscopy and Chemometrics. Appl.
Env.Microbiol. 70, 15831592.
Twist, C. R., Winson, M. K., Rowland, J. J. & Kell, D. B.
(2004) SNP
detection using nanomolar nucleotides and single molecule
fluorescence. Anal. Biochem. 327, 35-44.
King, R.D., Whelan, K.E., Jones, F.M., Reiser, P.G.K., Bryant,
C.H., Muggleton, S.H., Kell, D.B. & Oliver, S.G. (2004) Functional
genomic
hypothesis generation and experimentation by a robot scientist.
Nature 427, 247-252. Pubmed abstract.
Kell, D.B. & Oliver, S.G. (2004) Here is the
evidence, now what
is the hypothesis? The complementary roles of inductive and
hypothesis-driven science in the post-genomic era. Bioessays
26, 99-105. |
|
| 2003 |
Oates, M. J., Corne, D. W. & Kell, D. B. (2003). The bimodal feature at large population sizes and high selection pressure: implications for directed evolution. In Recent advances in simulated evolution and learning (ed. K. C. Tan, M. H. Lim, X. Yao and L. Wang), pp. 215-240. World Scientific, Singapore.
Vaidyanathan, S., Broadhurst, D. I.,
Kell, D. B. &
Goodacre, R. (2003) Explanatory
optimisation of
protein mass spectrometry via genetic search. Anal. Chem. 75,
6679-6686.
Kell, D. B., Mukamolova, G. V., Finan, C. L., Zhao, H., Goodacre,
R., Kaprelyants, A. S. & Young, M. (2003) Resuscitation
of 'uncultured' microorganisms. In Microbial diversity and
bioprospecting (ed. A. T. Bull), pp. 100-108. American Society for
Microbiology, Washington, DC.
Mukamolova, G. V., Kaprelyants, A. S., Kell, D. B. & Young, M.
(2003) Adoption
of the
transiently non-culturable state - a bacterial survival
strategy? Adv. Micr. Physiol. 47, 65-129.
Allen, J. K., Davey, H. M., Broadhurst, D., Heald, J. K., Rowland,
J. J., Oliver, S. G. & Kell, D. B. (2003) High-throughput
classification of yeast mutants for functional genomics using
metabolic footprinting. Nature Biotechnol. 21, 692-696.
Taylor, C. F., Paton, N. W., Garwood, K. L., Kirby, P. D., Stead,
D. A., Yin, Z., Deutsch, E. W., Selway, L., Walker, J., RibaGarcia,
I., Mohammed, S., Deery, M. J., Howard, J. A., Dunkley, T.,
Aebersold, R., Kell, D. B., Lilley, K. S., Roepstorff, P., Yates,
J. R., Brass, A., Brown, A. J. P., Cash, P., Gaskell, S. J.,
Hubbard, S. J. & Oliver, S. G. (2003) A
systematic
approach to modelling capturing and disseminating proteomics
experimental data. Nat Biotechnol 21, 247-254.
Goodacre, R. & Kell, D. B. (2003) Evolutionary computation for
the interpretation of metabolome data. In Metabolic profiling: its
role in biomarker discovery and gene function analysis (ed. G. G.
Harrigan and R. Goodacre), pp. 239-256. Kluwer Academic Publishers,
Boston.
Corne, D. W., Oates, M. J. & Kell, D. B. (2003) Landscape
State
Machines: tools for evolutionary algorithm performance analyses and
landscape/algorithm mapping. In Evoworkshops 2003, vol. LNCS
2611 (ed. S. Cagnoni, et al.), pp. 187-198. Springer, Berlin.
Corne, D. W., Oates, M. J. & Kell, D. B. (2003) Fitness gains
and mutation patterns: deriving mutation rates by exploiting
landscape data. In Foundations of Genetic Algorithms 7 (ed. K. A.
De Jong, R. Poli and J. E. Rowe), pp. 347-364. Morgan Kaufmann,
Amsterdam.
Kaderbhai, N. N., Broadhurst, D. I., Ellis, D. I., Goodacre, R.
& Kell, D. B. (2003) Functional
genomics via
metabolic footprinting: Monitoring metabolite secretion by
Escherichia coli tryptophan metabolism mutants using FT-IR and
direct injection electrospray mass spectrometry. Comp. Func.
Genomics 4, 376-391. |
|
| 2002 |
Goodacre, R., Vaidyanathan, S., Bianchi, G. & Kell, D. B.
(2002) Metabolic
profiling using direct infusion electrospray ionisation mass
spectrometry for the characterisation of olive oils. Analyst
127, 1457-1462. Abstract.
Hesketh, A. R., Chandra, G., Shaw, A. D., Rowland, J. J., Kell, D.
B., Bibb, M.J. & Chater, K. F. (2002) Primary
and
secondary metabolism, and post-translational protein modifications,
as portrayed by proteomic analysis of Streptomyces
coelicolor. Mol. Microbiol. 46, 917-932. Abstract.
Kell, D. B. (2002) Genotype-phenotype
mapping:
genes as computer programs. Trends Genet 18, 555-9. Abstract.
Mukamolova, G. V., Turapov, O. A., Young, D. I., Kaprelyants, A.
S., Kell, D. B. & Young, M. (2002) A
family of
autocrine growth factors in Mycobacterium tuberculosis.
Mol. Microbiol. 46, 623-635. Abstract.
Mukamolova, G. V., Turapov, O. A., Kazaryan, K., Telkov, M.,
Kaprelyants, A. S., Kell, D. B. & Young, M. (2002) The rpf gene of Micrococcus luteus encodes an essential
secreted
growth factor. Mol. Microbiol. 46, 611-621. Abstract.
Corne, D.W., Oates, M.J. & Kell, D.B. (2002) On fitness distributions and
expected fitness
gain of mutation rates in parallel evolutionary algorithms.
In
Parallel Problem Solving from Nature - PPSN VII. (eds. J.J. Merelo
Guervós, P. Adamidis, H.-G. Beyer, J.-L.
Fernández-Villacañas & H.-P. Schwefel)
132-141
(Springer, Berlin; 2002).
Kell, D.B. (2002) Metabolomics
and
machine learning: explanatory analysis of complex metabolome data
using genetic programming to produce simple, robust rules. Mol.
Biol. Rep. 29, 237-242.
Groeneveld, P., Rolley, N., Kell, D.B., Kelly, S.L. & Kelly,
D.E. (2002) Metabolic
control
analysis and engineering of the yeast sterol biosynthetic
pathway. Mol. Biol. Rep. 29, 27-29.
Pritchard, L. & Kell, D.B. (2002) Schemes
of
flux control in a model of Saccharomyces cerevisiae glycolysis. Eur. J. Biochem. 269, 3894-3904.
Lamb, D.C., Skaug, T., Song, H.L., Jackson, C.J., Podust, L.M.,
Waterman, M.R., Kell, D.B., Kelly, D.E. & Kelly, S.L. (2002) The
cytochrome
P450 complement (CYPome) of Streptomyces coelicolor A3(2). J. Biol. Chem. 277, 24000-5.
Vaidyanathan, S., Winder, C.L., Wade, S.C., Kell, D.B. &
Goodacre, R. (2002) Sample
preparation in matrix-assisted laser desorption ionization mass
spectrometry of whole bacterial cells and the detection of high
mass (>20 kDa) proteins. Rapid Comm. Mass Spectrom.
16:1276-1286.
Ellis, D. I., Broadhurst, D., Kell, D.B, Rowland, J.J. &
Goodacre, R. (2002) Rapid
and
quantitative detection of the microbial spoilage of meat using
Fourier-Transform infrared spectroscopy and machine learning.
Appl. Env. Microbiol. 68, 2822-2888. Abstract Pubmed. Abstract
ASM. Full
text at
ASM.
McGovern, A.C., Broadhurst, D., Taylor, J., Gilbert, R.J.,Winson,
M.K., Kaderbhai, N., Smal, D.A., Rowland, J.J., Kell, D.B. and
Goodacre, R. (2002) Monitoring
of complex
industrial bioprocesses for metabolite concentrations using modern
spectroscopies and machine learning: application to gibberellic
acid production. Biotechnol. Bioeng. 78, 527-538.
Shleeva, M.O., Bagramyan, K., Telkov, M.V., Mukamolova, G.V.,
Young, M., Kell, D.B. and Kaprelyants, A.S. (2002) Formation and
resuscitation of "non-culturable" cells of Rhodococcus
rhodochrous and Mycobacterium tuberculosis in prolonged
stationary phase. Microbiology 148, 1581-1591. Abstract. Full
text
at SGM.
Kell, D. B. (2002) Defence
against the flood: a solution to the data mining and predictive
modelling challenges of today. Bioinformatics World (part of
Scientific Computing News) Issue 1, 16-18. manuscript
Day, J.P., Kell, D.B. & Griffith, G.W. (2002) Differentiation
of Phytophthora infestans sporangia from other airborne
biological particles by flow cytometry. Appl. Env. Microbiol.
68, 37-45. Abstract. Full
text
at AEM.
Vaidyanathan S., Kell D.B. & Goodacre R. (2002) Flow-injection
electrospray ionization mass spectrometry of crude cell extracts
for high-throughput bacterial identification. J Am Soc Mass
Spectrom 13(2), 118-128 |
|
| 2001 |
Reiser P, King RD, Kell DB, Muggleton
SH, Bryant CH, Oliver SG
(2001) Developing
a logical model for yeast metabolism. Electronic Trans.
Artif.
Intell. 5, 223-244. preprint; as
published
Bryant CH, Muggleton SH, Oliver SG, Kell DB, Reiser P, King RD
(2001) Combining active
inductive
programming, active learning and robotics to discover the function
of genes. Electronic Trans. Artif. Intell., 5, 1-36. preprint; final
Woodward, A.M., Kaderbhai, N., Kaderbhai, M., Shaw, A.D., Rowland,
J.J. & Kell, D.B. (2001) Histometrics:
improvement
of the dynamic range of fluorescently stained proteins resolved in
electrophoretic gels using hyperspectral imaging. Proteomics
1,
1351-1358.
Vaidyanathan, S., Rowland, J.J., Kell, D.B. & Goodacre, R.
(2001) Discrimination
of
aerobic endospore-forming bacteria via electrospray ionization mass
spectrometry of whole cell suspensions. Anal. Chem. 73,
4134-4144. Abstract.
Kell, D.B., Darby, R.M. & Draper, J. (2001) Genomic
computing:
explanatory analysis of plant expression profiling data using
machine learning. Plant Physiology 126, 943.951. Abstract. Full
paper at
Plant Physiology.
Weichart, D.H. & Kell, D.B. (2001) Characterization
of an
autostimulatory substance produced by Escherichia coli.
Microbiology 147, 1875-1885. Abstract. Full
text
at SGM .
Bianchi, G., Giansante, L., Shaw, A.D. & Kell, D.B. (2001) Chemometric
criteria for the characterisation of Italian DOP olive oils from
their metabolic profiles. Eur. J. Lipid. Sci. Technol. 103,
141-150.
Mendes, P. & Kell, D.B. (2001) MEG (Model
Extender for
Gepasi): a program for the modelling of complex, heterogeneous,
cellular systems. Bioinformatics 17, 288-289. Abstract.
Clegg, J., Kell, D., Knull, H., Welch, G.R., Wilson, J. (2001) Macromolecular
interactions: tracing the roots. Trends Biochem. Sci 26, 91. Abstract.
Raamsdonk, L. M., Teusink, B., Broadhurst, D., Zhang, N., Hayes,
A., Walsh, M., Berden, J. A., Brindle, K. M., Kell, D. B., Rowland,
J. J., Westerhoff, H. V., van Dam, K. & Oliver, S. G. (2001) A
functional
genomics strategy that uses metabolome data to reveal the phenotype
of silent mutations. Nature Biotechnology 19, 45-50. Abstract.
Yardley, J., Kell, D.B., Barrett, J. & Davey, C.L. (2001) On-line,
real-time measurements of cellular biomass using dielectric
spectroscopy. Biotechnol. Genet. Eng. Rev. 17, 3-35. |
|
| 2000 |
Biketov, S., Mukamolova, G. V.,
Potapov, V., Gilenkov, E.,
Vostroknutova, G., Kell, D. B., Young, M. & Kaprelyants, A. S.
(2000) Culturability
of Mycobacterium tuberculosis cells isolated from
murine
macrophages: a bacterial growth factor promotes recovery. FEMS
Immunol. Med. Microbiol. 29, 233-240. Abstract.
Johnson, H.E., Gilbert, R.J., Winson, M.K., Goodacre, R., Smith,
A.R., Rowland, J.J., Hall, M.A. & Kell, D.B. (2000) Explanatory
analysis of the metabolome using genetic programming of simple,
interpretable rules. Genetic Programming and Evolvable
Machines
1, 243-258.
Barer M., Bogosian G., Kell D. & Williams, H. (2000) Resuscitating
a
logical approach to viability in the face of an "eastern
wind"
ASM News 66, 381-382. [Letter]
Wixon, J. & Kell, D.B. (2000) Website
review - The Kyoto Encyclopedia of Genes and Genomes - KEGG -
http://www.genome.ad.jp/kegg. Yeast 17, 48-55.
Gilbert, R. J., Rowland, J. J. & Kell, D. B. (2000) Genomic
computing: explanatory modelling for functional genomics. In
Proceedings of the Genetic and Evolutionary Computation Conference
(GECCO-2000) (ed. D. Whitley, D. Goldberg, E. Cantú-Paz, L.
Spector, I. Parmee and H.-G. Beyer), pp. 551-557. Morgan Kaufmann,
San Francisco. pdf version
of ms
here.
Davey, H. M., and Kell, D. B. (2000) A portable flow cytometer for
the detection and identification of microorganisms. In: Rapid
Methods for Monitoring the Environment for Biological Hazards, Eds.
P. J. Stopa and M. A. Bartoszcze, Kluwer Academic Publishers,
Dordrecht, 159-167.
Goodacre, R., Burton, R., Kaderbhai, N, Timmins, É.M.,
Woodward, A., Rooney, P.J. & Kell, D.B. (2000) Intelligent
systems for the characterisation of microorganisms from
hyperspectral data. In Rapid Methods for the Analysis of Biological
Materials in the Environment. Eds. P.J. Stopa & M.A.
Bartoszcze, Kluwer Academic Publishers, Dordrecht, 111-136.
Kaprelyants, A. S., Mukamolova, G. V., Votyakova, T. V., Davey, H.
M., and Kell, D. B. (2000) Dormancy in non-sporulating bacteria:
its significance for environmental monitoring. Rapid Methods for
Monitoring the Environment for Biological Hazards, P. J. Stopa and
M. A. Bartoszcze, eds., Kluwer Academic Publishers, Dordrecht,
49-65.
Yardley, J.E., Todd, R.W., Nicholson, D.J., Barrett, J., Kell, D.B.
& Davey, C.L. (2000) Correction
of the influence of baseline artefacts and electrode polarisation
on dielectric spectra. Bioelectrochem. Bioenerg. 51, 53-65. Abstract.
Kell, D.B. & Young, M. (2000) Bacterial
dormancy and culturability: the role of autocrine growth
factors. Curr. Opin. Microbiol. 3, 238-243.
Kell, D.B. (2000) Screen
idols - faster, smaller, cheaper and smarter. [meeting
report]
Trends Biotechnol. 18, 186-187. Journal ref.
Woodward, A.M., Davies, E.A., Denyer, S., Olliff, C. & Kell,
D.B. (2000) Non-linear
dielectric spectroscopy: antifouling and stabilisation of
electrodes by a polymer coating. Bioelectrochemistry 51,
13-20. Abstract.
Davies, Z.S., Gilbert, R.J., Merry, R.J., Kell, D.B., Theodorou,
M.K. & Griffith, G.W. (2000) Efficient
improvement of silage additives using genetic algorithms. Appl.
Env. Microbiol. 66, 1435-1443. Journal abstract. Pubmed abstract.
Kell, D.B. & King, R.D. (2000) On
the
optimization of classes for the assignment of unidentified reading
frames in functional genomics programmes: the need for machine
learning. Trends Biotechnol. 18, 93-98. Journal abstract. Pubmed abstract.
Davies, E., Woodward, A.M. & Kell, D.B. (2000) The
use of nonlinear dielectric spectroscopy to monitor the
bioelectromagnetic effects of a weak pulsed magnetic field in real
time. Bioelectromagnetics 21, 25-33. 30
Goodacre, R., Shann, B., Gilbert, R.J., Timmins, É.M.,
McGovern, A., Alsberg, B.K., Kell, D.B. & Logan, N.A. (2000) The
detection of the dipicolinic acid biomarker in Bacillus spores using Curie-point pyrolysis mass spectrometry and
Fourier-transform infrared spectroscopy. Anal. Chem. 72,
119-127. Journal abstract. Pubmed abstract.
Shaw, A.D., Winson, M.K., Woodward, A.M., McGovern, A., Davey,
H.M., Kaderbhai, N., Broadhurst, D.I., Gilbert, R.J., Taylor, J.,
Timmins, É.M., Alsberg, B.K., Rowland, J.J., Goodacre, R.
& Kell, D.B. (2000) Rapid
analysis of
high-dimensional bioprocesses using multivariate spectroscopies and
advanced chemometrics. Adv. Biochem. Eng. 66, 83-113. Abstract. |
|
| 1999 |
Kell, D.B. & Mendes, P.
(1999) Snapshots of systems -
metabolic control analysis and biotechnology in the post-genomic
era. In Technological and Medical Implications of Metabolic
Control Analysis (A. Cornish-Bowden and
M.L.Cárdenas, ed.)
pp. 3-25. Kluwer Academic Publishers, Dordrecht. Ms available in Postscript or pdf versions.
See also a draft
(pre-meeting) web version .
Shaw, A.D., Kaderbhai, N., Jones, A., Woodward, A.M., Goodacre, R.,
Rowland, J.J. & Kell, D.B. (1999) Non-invasive,
on-line monitoring of the biotransformation by yeast of glucose to
ethanol using dispersive Raman spectroscopy and chemometrics. Appl. Spectroscopy. 53, 1419-1428. WoS abstract.
Vlahov, G., Shaw, A.D. & Kell, D.B. (1999) Use of 13C
NMR DEPT pulse
sequence and multivariate analysis to
discriminate olive oil cultivars. J. Amer. Oil Chemists Soc., 76,
1223-1231.
Mukamolova, G.V., Kormer, S.S., Kell, D.B. & Kaprelyants, A.S.
(1999) Stimulation
of the multiplication of Micrococcus luteus by an
autocrine growth factor. Arch.Microbiol. 172, 9-14. Abstract.
McGovern, A.C., Ernill, R., Kara, B.V., Kell, D.B. & Goodacre,
R. (1999) Rapid
analysis
of the expression of heterologous proteins in Escherichia
coli using pyrolysis mass spectrometry and Fourier transform
infrared spectroscopy with chemometrics: application to
face="Symbol">a2-interferon production. J.
Biotechnol. 72,
157-167. Abstract.
Goodacre, R. Heald, J.K. & Kell, D.B. (1999) Characterisation
of intact microorganisms using electrospray ionisation mass
spectrometry. FEMS Microbiology Letters 176, 17-24.
Woodward, A.M., Gilbert, R.J. & Kell, D.B. (1999) Genetic
programming as an analytical tool for non-linear dielectric
spectroscopy. Bioelectrochem. Bioenerg. 48, 389-396. Abstract.
Gilbert, R.J., Johnson, H.E., Winson, M.K., Rowland, J.J.,
Goodacre, R., Smith, A.R., Hall, M.A. & Kell, D. B. (1999) Genetic
programming as an analytical tool for metabolome data.
Langdon,
W.B., Poli, R., Nodin, P. & Fogarty, T. (eds) Late-breaking
papers of EuroGP-99, pp. 23-33.
Davies, E., Olliff, C., Wright, I., Woodward, A. & Kell, D.B.
(1999) A
weak
pulsed magnetic field affects adenine nucleotide oscillations and
related parameters in aggregating Dictyostelium discoideum amoebae. Bioelectrochem. Bioenerg. 48, 149-162.
Davey, H.M., Kaprelyants, A.S., Weichart, D.H. and Kell, D.B.
(1999) Approaches
to the
estimation of microbial viability using flow cytometry. In:
Current Protocols in Cytometry: Volume 11 Microbial Cytometry, pp.
11.3.1-11.3.20 . Robinson, J.P. (Ed.) Wiley, New York.
Kaprelyants, A.S., Mukamolova, G.V., Kormer, S.S., Weichart, D.H.,
Young, M. & Kell, D.B. (1999) Intercellular
signalling and the multiplication of prokaryotes: bacterial
cytokines. Symp. Soc. Gen. Microbiol. 57, 33-69.
Kell, D.B. (1999) Screensavers:
trends in high-throughput analysis [meeting report]. Trends
in
Biotechnol. 17, 89-91.
Kell, D.B. (1999) Nonviable
and
nonculturable [letter]. ASM News 65(1), 1.
Davey H.M., Jones A., Shaw A.D. and Kell D.B. (1999) Variable
selection and multivariate methods for the identification of
microorganisms by flow cytometry. Cytometry 35, 162-168. Abstract |
|
| 1998 |
Mendes, P. & Kell, D.B.
(1998) Nonlinear
optimisation of metabolic pathways: applications to metabolic
engineering and parameter estimation. Bioinformatics 14,
869-883. Abstract. Abstract at journal with link to pdf.
Goshawk, J.A., Binding, D.M., Kell, D.B. & Goodacre, R. (1998) Rheological
phenomena occurring during the shearing flow of mayonnaise. J.
Rheology 42, 1537-1553. Abstract at AIP with link to pdf.
Kell, D.B. (1998) From code to mode for orphan genes. [Meeting
report]. Trends Biotechnol. 16, 491-493. Abstract.
Alsberg, B.K., Kell, D.B. & Goodacre, R. (1998) Variable
selection in discriminant partial least squares analysis. Anal.
Chem., 70, 4126-4133.
Davey, C.L. & Kell, D.B. (1998) The
influence of electrode polarisation on dielectric spectra, with
special reference to capacitive biomass measurements. II. reduction
in the contribution of electrode polarisation to dielectric spectra
using a two-frequency method. Bioelectrochem. Bioenerg. 46,
105-114.
Davey, C.L. & Kell, D.B. (1998) The
influence of electrode polarisation on dielectric spectra, with
special reference to capacitive biomass measurements. I.
quantifying the effects on electrode polarisation of factors likely
to occur during fermentations. Bioelectrochem. Bioenerg. 46,
91-103.
Mendes, P. & Kell, D.B. (1998) Numerical optimisation and
simulation for rational metabolic engineering. In BioThermoKinetics
in the post-genomic era (eds Larsson, C., Påhlman, I.-L.
&
Gustafsson, L.) Chalmers Reproservice, Göteborg, pp. 345-349. Full
paper.
Barer, M. R., Karelyants, A. S., Weichart, D. H., Harwood, C. R.
& Kell, D. B. (1998) Microbial stress and culturability:
conceptual and operational domains. Microbiology 144,
2009-2010.
Taylor, J., Rowland, J.J. & Kell, D.B. (1998) Genetic
programming applied to the rapid spectroscopic analysis of
biological samples. In Koza, JR (ed) Late-breaking papers at the
Genetic Programming 1998 Conference, University of Wisconsin, July
22-25 1998. Omni Press, Madison.
Taylor, J., Rowland, J.J., Goodacre, R., Gilbert, R.J., Winson,
M.K. & Kell, D.B. (1998) Genetic programming in the
interpretation of Fourier transform infrared spectra:
quantification of metabolites of pharmaceutical importance. In
(Koza, J.R., Banzhaf, W., Chellapilla, K., Deb, K., Dorigo, M.,
Fogel, D.B., Garzon, M.H., Goldberg, D.E., Iba, H. & Riolo,
R.L., eds.) Genetic Programming 1998: Proceedings of the Third
Annual Conference, Madison, WI. (Morgan Kaufmann, San Francisco,
CA, pub). pp. 377-380.
Gilbert, R.J., Goodacre, R., Shann, B., Taylor, J., Rowland, J.J.
& Kell, D.B. (1998) Genetic programing-based variable selection
for high-dimensional data. In (Koza, J.R., Banzhaf, W.,
Chellapilla, K., Deb, K., Dorigo, M., Fogel, D.B., Garzon, M.H.,
Goldberg, D.E., Iba, H. & Riolo, R.L., eds.) Genetic
Programming 1998: Proceedings of the Third Annual Conference,
Madison, WI. (Morgan Kaufmann, San Francisco, CA, pub.). pp.
109-115.
Oliver, S.G., Winson, M.K., Kell, D.B. & Baganz, F. (1998) Systematic
functional analysis of the yeast genome. Trends Biotechnol.
16,
373-378. Abstract. Manuscript in Postscript. Web
version at Tibtech
Mukamolova, G.V., Kaprelyants, A.S., Young, D.I., Young, M. &
Kell, D.B. (1998) A
bacterial
cytokine. Proc. Natl. Acad. Sci. 95, 8916-8921. PubMed abstract. Abstract at PNAS with link to pdf. Full pdf version freely available at PubMedCentral.
Woodward, A.M., Alsberg, B.K & Kell, D.B. (1998) The effect of heteroscedastic noise on the modelling of frequency
domain data. Chemometr. Intell. Lab. Syst. 40, 101- 107
Alsberg, B.K., Woodward, A.M., Winson, M.K., Rowland, J.J. &
Kell, D.B. (1998) Variable
selection in wavelet regression models. Analytica Chimica
Acta,
368, 29- 44.
Jones, A., Young, D., Taylor, J., Kell, D.B. & Rowland, J.J.
(1998) Quantification
of microbial productivity via multi-angle light scattering and
supervised learning. Biotechnol. Bioeng., 59, 131-143. Abstract.
Winson, M.K., Kaderbhai, N., Jones, A., Alsberg, B.K., Woodward,
A.M., Shaw, A.D., Goodacre, R., Rowland, J.J., Kell, D.B., Todd, M.
& Rudd, B.A.M. (1998) Metabolic microscopy: novel approaches to
high-throughput screening in strain development and fermentation
analysis using diffuse reflectance FT-IR and dispersive Raman
spectroscopy with chemometrics. In (Dixon, G.K., Major, J.S. &
Rice, M.J., eds) Challenges and issues in high throughput
screening: a pharmaceutical and agrochemical industry
perspective, pp. 151-152. SCI, London.
Kell, D.B., Kaprelyants, A.S., Weichart, D.H., Harwood, C.L. &
Barer, M.R. (1998) Viability
and activity in readily culturable bacteria: a review and
discussion of the practical issues. Antonie van Leeuwenhoek
73,
169-187. Abstract.
Goodacre, R., Timmins, É.M., Burton, R., Kaderbhai, N,
Woodward, A., Kell, D.B. & Rooney, P.J. (1998) Rapid identification of urinary tract infection bacteria using
hyperspectral, whole organism fingerprinting and artificial neural
networks. Microbiology 144, 1157- 1170. PubMed abstract. Abstract at Microbiology with link to pdf.
Goodacre, R., Rooney, P.J. & Kell, D.B. (1998) Rapid analysis
of microbial systems using vibrational spectroscopy and supervised
learning methods: application to the discriminatin
betweenmethicillin-resistant and methicillin-susceptible Staphylococcus
aureus. In
Infrared Spectroscopy: New Tool in
Medicine. Proc. SPIE 3257, 220-229.
Kell, D.B. & Kaprelyants, A.S. (1998) Are many microbial
secondary metabolites really pheromones with important
physiological functions, a knowledge of which could guide discovery
programmes? Dormancy, differentiation, social resuscitation and
pheromone production in nonsporulating bacteria. In Marine
microorganism: research issues for biotechnology. Proc. US/EC
Workshop on Marine Microorganisms, pp. 87-92. Publ.
European
Commission, Brussels.
Kell, D.B., Winson, M., Goodacre, R., Alsberg, B., Jones, A.,
Woodward, A. & Rowland, J. (1998) DRASTIC (Diffuse Reluctance
Absorbance SpectroscopyTaking in Chemometrics): a rapid remote
sensing method for assessing metabolite overproduction in titre
improvement programmes. Global Drug Discovery: exploiting
technologies to accelerate drug development, ed. Savage, L.M.,
publ. International Business Communications, Southborough, Mass,
pp. 219-283.
Kell, D.B. & Todd, R.W. (1998) Dielectric
estimation of microbial biomass using
the Aber instruments biomass monitor. Trends Biotechnol. 16,
149-150.
Votyakova, T. V., Mukamolova, G. V., ShteinMargolina, V. A., Popov,
V. I., Davey, H. M., Kell, D. B. & Kaprelyants, A. S. (1998)
Research on the heterogeneity of a Micrococcus luteus culture during an extended stationary phase: Subpopulation
separation and characterization. Microbiology (Russia) 67,
71-77.
Taylor, J., Goodacre, R., Wade, W.G., Rowland, J.J. & Kell,
D.B. (1998) The
deconvolution of pyrolysis mass spectra using genetic programming:
application to the identification of some Eubacterium species. FEMS Microbiology Letters 160, 237- 246. Abstract.
Jones, A., Shaw, A.D., Salter, G.J., Bianchi, G. & Kell, D.B.
(1998) The exploitation of chemometric methods in the analysis of
spectroscopic data: application to olive oils. in Lipid
Analysis
of Oils and Fats (ed. R.J. Hamilton), publ. Chapman &
Hall,
pp 317-376.
Goodacre, R., Rooney, P.J. & Kell, D.B. (1998) Discrimination
between susceptible and methicillin-resistant Staphylococcus
aureus using pyrolysis mass spectrometry and artificial
neural
networks. J. Antimicrobial Chemotherapy 41, 27-34. Abstract.
Winson, M. K., Todd, M., Rudd, B. A. M., Jones, A., Alsberg, B. K.,
Woodward, A. M., Goodacre, R., Rowland, J. J. & Kell, D. B.
(1998) A DRASTIC (Diffuse Reflectance Absorbance Spectroscopy
Taking in Chemometrics) approach for the rapid analysis of
microbial fermentation products: quantification of aristeromycin
and neplanocin A in Streptomyces citricolor broths. New
frontiers in screening for microbial biocatalysts (Kieslich,
K., van der Beek, C.P., de Bont, J.A.M. & van den Tweel,
W.J.J., eds), pp. 185-191. Elsevier, Amsterdam.
Kell, D.B., Winson, M.K., Goodacre, R., Woodward, A.M., Alsberg,
B.K., Jones, A., Timmins, É and Rowland, J.J. (1998) DRASTIC
(Diffuse Reflectance Absorbance Spectroscopy Taking In
Chemometrics). A novel, rapid, hyperspectral, FT-IR-based approach
to screening for biocatalytic activity and metabolite
overproduction. In New frontiers in screening for microbial
biocatalysts (Kieslich, K., van der Beek, C.P., de Bont,
J.A.M.
& van den Tweel, W.J.J., eds), pp. 61-75. Elsevier,
Amsterdam. |
|
| 1997 |
Jones, A., Rowland, J.J., Woodward,
A.M. & Kell, D.B.
(1997) An
instrument for the acquisition and analysis of the nonlinear
dielectric spectra of biological samples. Trans. Inst. Meas.
Control 19, 223-230.
Gilbert, R.J., Goodacre, R., Woodward, A.M. & Kell, D.B. (1997) Genetic
programming: a novel method for the quantitative analysis of
pyrolysis mass spectral data. Anal. Chem. 69, 4381-4389.
Goodacre, R., Timmins, É.M., Jones, A., Kell, D.B., Maddock,
J., Heginbothom, M.L. and Magee, J.T. (1997) On
mass spectrometer instrument standardization and interlaboratory
calibration transfer using neural networks. Anal. Chim. Acta
348, 511-532.
Alsberg, B.K., Goodacre, R., Rowland, J.J. & Kell, D.B. (1997) Classification
of pyrolysis mass spectra by fuzzy multivariate rule induction;
comparison with regression, K- nearest neighbour, neural and
decision-tree methods. Anal. Chim. Acta 348, 389-407.
Shaw, A.D., di Camillo, A., Vlahov, G., Jones, A., Bianchi, G.,
Rowland, J. & Kell, D.B. (1997) Discrimination
of the variety and region of origin of extra virgin olive oils
using 13C NMR and multivariate calibration with
variable
reduction. Anal. Chim. Acta 348, 357-374.
Winson, M.K., Goodacre, R., Timmins, É., Jones, A., Alsberg,
B.K., Woodward, A.M., Rowland, J.J. & Kell, D.B. (1997) Diffuse
Reflectance Absorbance Spectroscopy Taking In Chemometrics
(DRASTIC). A hyperspectral FT-IR-based approach to rapid screening
for metabolite overproduction. Anal. Chim. Acta 348,
273-282.
Broadhurst, D., Goodacre, R., Jones, A., Rowland, J.J. & Kell,
D.B. (1997) Genetic
algorithms as a method for variable selection in PLS regression,
with applications to pyrolysis mass spectrometry. Anal. Chim.
Acta 348, 71-86.
Tidswell, E.C., Salter, G.J., Kell, D.B. & Morris, J.G. (1997) Enantioselectivity
of sulcatone reduction by some anaerobic bacteria. Enz. Micr.
Technol. 21, 143-147.
Kell, D.B. (1997) Target
practice
- novel approaches to antimicrobial chemotherapy [meeting
report]. Trends Biotechnol. 15, 334-336.
Davey, H.M. & Kell, D.B. (1997) Fluorescent
brighteners: novel stains for the flow cytometric analysis of
microorganisms. Cytometry 28, 311-315. Abstract.
Davey, C.L., Guan, Y., Kemp, R.B. & Kell, D.B. (1997) Real-time
monitoring of the biomass content of animal cell cultures using
dielectric spectroscopy. In Animal cell technology: basic and
applied aspects, Vol 8, ed. K. Funatsu, Y. Shirai &
T.
Matsushita, pp. 61-65, publ. Kluwer, Dordrecht.
Alsberg, B.K., Woodward, A.M. & Kell, D.B. (1997) An introduction to wavelet transforms for chemometricians: a
time-frequency approach. Chemometrics and Intelligent
Laboratory Systems 37, 215-239.
Salter G.J., Lazzari M., Giansante L., Goodacre R., Jones, A.,
Surricchio G., Kell D.B. and Bianchi G. (1997) Determination
of the geographical origin of Italian extra virgin olive oil using
pyrolysis mass spectrometry and artificial neural networks. J.
Anal. Appl. Pyrol. 40/41, 159-170.
Goodacre, R., Hammond, D. & Kell, D.B. (1997) Quantitative
analysis of the adulteration of orange juice with sucrose using
pyrolysis mass spectrometry and chemometrics. J. Anal. Appl.
Pyrol. 40/41, 135-158.
Alsberg, B.K., Woodward, A.M., Winson, M.K., Rowland, J.J. and
Kell, D.B. (1997) Wavelet
denoising of infrared spectra. Analyst 122, 645-652.
Alsberg, B.K., Winson, M.K. & Kell, D.B. (1997) Improving
interpretation of multivariate and rule induction models by using a
spectral peak parameter representation. Chemometrics and
Intelligent Laboratory Systems, 36, 95-109.
Winson, M.K. & Kell, D.B. (1997) If
you've got it, flaunt it - rapid screening for microbial
biocatalysts [meeting report] Trends Biotechnol. 15,
120-122.
Mendes, P. & Kell, D.B. (1997) Making
cells
work - metabolic engineering for everyone. [meeting report]
Trends Biotechnol. 15, 6-7. |
|
| 1996 |
Goodacre, R., Rischert, D.J., Evans,
P.M. & Kell, D.B.
(1996) Rapid authentication of animal cell lines using pyrolysis
mass spectrometry and auto-associative artificial neural networks. Cytotechnology 21, 231-241.
Davey, H.M. & Kell, D.B. (1996) Flow
cytometry and cell sorting of heterogeneous microbial populations:
the importance of single-cell analyses. Microbiol. Rev. 60,
641-696. Abstract.
Westerhoff, H.V. & Kell, D.B. (1996) What
BioTechnologists knew all along...? J. Theoret. Biol. 182,
411-420. Abstract.
Woodward, A.M., Jones, A., Zhang, X.-Z., Rowland, J. & Kell,
D.B. (1996) Rapid
and
non-invasive quantification of metabolic substrates in biological
cell suspensions using nonlinear dielectric spectroscopy with
multivariate calibration and artificial neural networks. Principles
and applications. Bioelectrochem. Bioenerg. 40, 99-132.
Goodacre, R., Neal, M.J. & Kell, D.B. (1996) Quantitative
analysis of multivariate data using artificial neural networks: a
tutorial review and applications to the deconvolution of pyrolysis
mass spectra. Zentralblatt. für Bakteriologie 284, 516-539. Abstract.
Kell, D.B., Goodacre, R. & Neal, M.J. (1996) Rapid analysis of
multiple determinands using pyrolysis mass spectrometry and
supervised learning with artificial neural networks. In (Berg,
D.A., ed.) Proc. 1994 ERDEC Scientific Conference on chemical and
biological defense research, pp 53-59. ERDEC-SP-036, Aberdeen
Proving Ground.
Mendes, P. & Kell, D.B. (1996) Biothermokinetics, metabolic
control analysis, metabolic engineering and the World Wide Web:
rapid dissemination over the Internet. In Westerhoff H.V.,
Snoep J.L., Sluse F.E., Wijker J.E. and Kholodenko B.N. (eds.)
BioThermoKinetics of the Living Cell, pp. 254-257,
BioThermoKinetics Press, Amsterdam.
Mendes, P. & Kell, D.B. (1996) Computer simulation of
biochemical kinetics. In Westerhoff H.V., Snoep
J.L., Sluse
F.E., Wijker J.E. and Kholodenko B.N. (eds.) BioThermoKinetics of
the Living Cell, pp. 245-251, BioThermoKinetics Press,
Amsterdam.
Goodacre, R., Pygall, J. & Kell, D.B. (1996) Plant seed classification using pyrolysis mass spectrometry with
unsupervised learning; the application of auto-associative and
Kohonen artificial neural networks. Chemometr. Intell. Lab.
Syst., 34, 69-83.
Winson, M.K. & Kell, D.B. (1996) Going places: forced and natural molecular evolution (Meeting
report). Trends Biotechnol. 14, 323-325.
Goodacre, R., Timmins, É.M., Rooney, P.J., Rowland, J.J.
&
Kell, D.B. (1996) Rapid identification of Streptococcus species using
diffuse
reflectance-absorbance Fourier transform infrared spectroscopy and
artificial neural networks. FEMS Microbiol. Lett. 140,
233-239. Abstract.
Davey, H.M., Davey, C.L., Woodward, A.M., Edmonds, A.N., Lee, A.W.
& Kell, D.B. (1996) Oscillatory,
stochastic and chaotic growth rate fluctuations in
permittistatically- controlled yeast cultures. Biosystems 39,
43-61. Abstract.
Kell, D.B. (1996) Membrane tension (letter). Trends Cell Biol. .6,
171.
Kaprelyants, A.S. & Kell, D.B. (1996) Do
bacteria need to communicate with each other for growth? Trends
Microbiol. 4, 237-242. Abstract.
Kaprelyants, A.S., Mukamolova, G.V., Davey, H.M. & Kell, D.B.
(1996) Quantitative analysis of the physiological heterogeneity within
starved cultures of Micrococcus luteus using flow
cytometry
and cell sorting. Appl. Env. Microbiol. 62, 1311-1316.
Nicholson, D.J., Kell, D.B. & Davey, C.L. (1996) Deconvolution
of the dielectric spectra of microbial cell suspensions using
multivariate calibration and artificial neural networks. Bioelectrochem. Bioenerg. 39, 185-193.
Goodacre, R. & Kell, D.B. (1996) Neural network analyses of
pyrolysis mass spectral data: applications to the assessment of
food adulteration, monitoring fermentor broths, and the correction
of mass spectral drift. Proceedings of MolMass 96 - 2nd
International Conference on Molecular Mass Characterization of
Synthetic and Natural Polymers, 1-4 April, 1996. 7 pp
Mendes, P., Kell, D.B. & Westerhoff, H.V. (1996) Why
and
when channelling can decrease pool size at constant net flux in a
simple dynamic channel. Biochim. Biophys. Acta 1289, 175-186. Abstract.
Mendes, P. & Kell, D.B. (1996) On
the analysis of the inverse problem of metabolic pathways using
artificial neural networks. Biosystems 38, 15-28. Abstract.
Goodacre, R. & Kell, D.B. (1996) Pyrolysis
mass spectrometry and its applications in biotechnology. Curr.
Opinion Biotechnol. 7, 20-28. Abstract.
Goodacre, R. & Kell, D.B. (1996) Correction
of mass spectral drift using artificial neural networks. Anal.
Chem. 68, 271-280. Abstract. |
|
| 1995 |
Kell, D.B., Davey, H.M., Mukamolova,
G.V., Votyakova, T.V.
& Kaprelyants, A.S. (1995) A summary of recent work on dormancy
in non-sporulating bacteria: significance for marine microbiology
and biotechnology. J. Marine Biotechnol. 3, 24-25.
Davey, C.L. & Kell, D.B. (1995) The low-frequency dielectric
properties of biological cells. In (D. Walz, H. Berg & G.
Milazzo, eds) Bioelectrochemistry of cells and tissues, pp.
159-207, Birkhäuser, Zürich.
Kell, D.B. & Sonnleitner, B. (1995) GMP
- Good Modelling Practice: an essential component of good
manufacturing practice. Trends Biotechnol., 13, 481-492.
Goodacre, R., Trew, S., Wrigley-Jones, C., Saunders, G., Neal,
M.J., Porter, N. & Kell, D.B. (1995) Rapid and quantitative analysis of metabolites in fermentor broths
using pyrolysis mass spectrometry with supervised learning:
application to the screening of Penicillium chryosgenum fermentations for the overproduction of penicillins. Anal.
Chim. Acta 313, 25-43.
Salter, G.J. and Kell, D.B. (1995) Solvent
selection for whole cell biotransformations in organic media. CRC Crit Rev. Biotechnol. 15, 139-177. Abstract.
Mendes, P., Kell, D.B. & Westerhoff, H.V. (1995) A series of
cases in which metabolic channeling can decrease the pool size at
constant net flux in a simple dynamic channel. Biochem. Soc. Trans.
23, S 287
Woodward, A.M. & Kell, D.B. (1995) On
harmonic generation in nonlinear biological systems. Biosensors
Bioelectronics 10, 639-641.
Goodacre, R., Biamchi, G. & Kell, D.B. (1995) Food adulteration
exposed by neural networks. Analysis Europa, June issue, pp.
35-37.
Mukamolova G.V., Yanopolskaya N.D., Votyakova T.V., Popov V.I.,
Kaprelyants A.S. & Kell D.B. (1995) Biochemical
changes accompanying the long-term starvation of Micrococcus
luteus cells in spent growth medium. Arch.
Microbiol. 163,
373-379.
Mendes, P., Kell, D.B. & Welch, G.R. (1995) Metabolic
channeling in organized enzyme systems: experiments and models. In:
Enzymology in
vivo (Adv. Mol. Cell. Biol. 11,
1-19) (ed. K. Brindle), JAI Press, London. Manuscript
in pdf .
Mukamolova, G.V., Kaprelyants, A.S. & Kell, D.B. (1995) Secretion
of an antibacterial factor during resuscitation of
dormant cells in Micrococcus luteus cultures held
in an
extended stationary phase. Antonie van Leeuwenhoek, 67,
289-295. Abstract.
Markx, G.H. & Kell, D.B. (1995) The
use of dielectric permittivity for the control of the biomass level
during biotransformations of toxic substrates in continuous
culture. Biotechnology Progress, 11, 64-70. Abstract.
Kell, D.B., Kaprelyants, A.S. & Grafen, A. (1995) On
pheromones, social behaviour and the functions of secondary
metabolism in bacteria. Trends Ecol. Evolution 10, 126-
129. |
|
| 1994 |
Davey, H.M. and Kell, D.B. (1994)
Rapid flow cytometric
detection and identification of microbial particles. In (Berg,
D.A., ed.) Proc. 1994 ERDEC Scientific Conference on chemical and
biological defense research, pp 593-599. ERDEC-SP-036, Aberdeen
Proving Ground.
Tatebe, W., Woodward, A.M. & Kell, D.B. (1994) Nonlinear
dielectric properties and their relationship to the physiological
state (resting or active) of Saccharomyces cerevisiae.
Mem.
Fac. Eng. Osaka City Univ. 35, 53-57.
Goodacre, R., Trew, S., Wrigley-Jones, C., Neal, M.J., Maddock, J.,
Ottley, T.W., Porter, N. & Kell, D.B. (1994) Rapid
screening for metabolite overproduction in fermentor broths, using
pyrolysis mass spectrometry with multivariate calibration and
artificial neural networks. Biotechnol. Bioeng. 44,
1205-1216.
Kell, D.B., Goodacre, R. & Neal, M.J. (1994) The
dogs that did not bark. Trends Biotechnol. 12, 494-495
(refereed letter).
Mendes, P. & Kell, D.B. (1994) Simultaneous estimates of
single-enzyme kinetic parameters for multi-enzymatic systems using
artificial neural networks. in What is controlling
life? 50
years after Schrödinger's What is Life?
(E. Gnaiger,
F.N. Gellerich & M. Wyss, eds) Modern Trends in
Biothermokinetics Vol 3, 302-304. Innsbruck University Press,
Innsbruck.
Kell, D.B., Davey, H.M., Mukamolova, G.V., Votyakova, T.V. &
Kaprelyants, A.S. (1994) Life, death, dormancy and social
resuscitation in non-sporulating bacteria: relationships with the
energetic status of individual cells. in What is
controlling
life? 50 years after Schrödinger's What is Life?
(E.
Gnaiger, F.N. Gellerich & M. Wyss, eds) Modern Trends in
Biothermokinetics Vol 3, 252-254. Innsbruck University Press,
Innsbruck.
Mendes, P, Kell, D.B. & Westerhoff, H.V. (1994) How to vary the
proportion of dynamic channelling flux at constant total flux (and
decrease the intermediate pool size...). in What is
controlling life? 50 years after Schrödinger's What
is
Life? (E. Gnaiger, F.N. Gellerich & M. Wyss, eds)
Modern
Trends in Biothermokinetics Vol 3, 202-204. Innsbruck University
Press, Innsbruck.
Beving, H., Eriksson, L.E.G., Davey, C.L. & Kell, D.B. (1994) Dielectric
properties of human erythrocytes and blood at radio frequencies
(0.2 - 10 MHz); dependence on cell volume fraction and medium
composition. Eur. Biophys. J. 23, 207-215. Abstract.
Votyakova, T.V., Kaprelyants, A.S. & Kell, D.B. (1994) Influence
of viable cells on the resuscitation of dormant cells in Micrococcus
luteus cultures
held in extended stationary
phase. The population effect. Appl. Env. Microbiol. 60,
3284-3291.
Kell, D.B. & Woodward, A.M. (1994) The nonlinear dielectric
properties of biological systems: a set of methods for assessing
the behaviour of enzymes in situ. In (H.V.
Westerhoff, ed.) Biothermokinetics. Intercept
Press, London, pp 431-434.
Neal, M.J., Goodacre, R. & Kell, D.B. (1994) On the analysis of
pyrolysis mass spectra using artificial neural networks. Individual
input scaling leads to rapid learning. Proceedings of the World
Congress on Neural Networks 1994, San Diego, I-318 - I-323.
Goodacre, R., Karim, A., Kaderbhai, M. & Kell, D.B. (1994) Rapid
and quantitative analysis of recombinant protein expression using
pyrolysis mass spectrometry and artificial neural networks:
application to mammalian cytochrome b5 in Escherichia coli. J. Biotechnol., 34, 185-193. Abstract.
Goodacre, R., Neal, M.J. & Kell, D.B. (1994) Rapid
and quantitative deconvolution of the pyrolysis mass spectra of
complex binary and tertiary mixtures using multivariate calibration
and artificial neural networks. Anal. Chem., 66, 1070-1085.
Kell, D.B. (1994) Between
the bud and the rose [book review]. Trends Biochem. Sci. 19,
184.
Kaprelyants, A.S., Mukamolova, G.V. & Kell, D.B. (1994) Estimation
of dormant Micrococcus luteus cells by penicillin
lysis and by resuscitation in cell-free spent culture medium at
high dilution. FEMS Microbiol. Lett., 115, 347-352. |
|
| 1993 |
Goodacre, R., Neal, M.J., Kell, D.B.,
Greenham, L.W., Noble,
W.C. & Harvey, R.G. (1993) Rapid identification using pyrolysis
mass spectrometry and artificial neural networks of Propionibacterium
acnes isolated from dogs. J. Appl.
Bacteriol., 76, 124-134. Abstract.
Mendes, P. & Kell, D.B. (1993) Control analysis of metabolic
channelling. Modern Trends in Biothermokinetics, eds S. Schuster,
M. Rigoulet, R. Ouhabi & J.-P. Mazat, Plenum Press, New York
and London, 211-216.
Kell, D.B., Davey, C.L., Goodacre, R. & Sauro, H.M. (1993) When
going backwards means progress: on the solution of biochemical
inverse problems using artificial neural networks. Modern Trends in
Biothermokinetics, eds S. Schuster, M. Rigoulet, R. Ouhabi &
J.-P. Mazat, Plenum Press, New York and London, 109-114.
Goodacre, R., Kell, D.B. & Bianchi, G. (1993) Rapid
assessment using pyrolysis mass spectrometry and artificial neural
networks of the adulteration of virgin olive oils by other seed
oils. J. Sci. Food Agric. 63, 297-307.
Davey, H.M., Davey, C.L. & Kell, D.B. (1993) SKATGRAF: a
stand-alone program for the calibration and plotting of flow
cytometric data. Binary 5, 165-170.
Mendes, P. & Kell, D.B. (1993) On
the
role of enzyme kinetic parameters in determining the effectiveness
with which channelling can decrease the size of a metabolite
pool. Acta Biotheoretica 41, 63-73. Abstract.
Kaprelyants, A.S. & Kell, D.B. (1993) Dormancy in stationary-phase cultures of Micrococcus luteus:
flow cytometric analysis of starvation and resuscitation. Appl.
Env. Microbiol. 59, 3187-3196.
Goodacre, R. Edmonds, A.N. & Kell, D.B. (1993) Quantitative
analysis of the pyrolysis mass spectra of complex mixtures using
artificial neural networks: application to amino acids in
glycogen. J. Anal. Appl. Pyrol. 26, 93-114.
Davey, C.L., Markx, G.H. & Kell, D.B. (1993) On the
dielectric
method of monitoring cellular viability. Pure Appl. Chem. 65,
1921-1926.
Davey, C.L., Davey, H.M., Kell, D.B. & Todd, R.W. (1993) An
introduction to the dielectric estimation of cellular biomass in
real time, with special emphasis on measurements at high volume
fractions. Anal. Chim. Acta 279, 155-161.
Goodacre, R. & Kell, D.B. (1993) Rapid
analysis of bioprocesses using pyrolysis mass spectrometry and
neural networks: application to indole production. Anal.
Chim.
Acta 279, 17-26.
Goodacre, R., Kell, D.B. & Bianchi, G. (1993) Olive oil quality
control by using pyrolysis mass spectrometry and artificial neural
networks. Olivæ 47, 36-38.
Goodacre, R., Kell, D.B. & Bianchi, G. (1993) Rapid assessment
of food adulteration using pyrolysis mass spectrometry and neural
networks: application to extra virgin olive oils. Central Office of
Information Newsletter.
Kaprelyants, A.S., Gottschal, J.C. & Kell, D.B. (1993) Dormancy in nonsporulating bacteria. FEMS Microbiol. Rev.
104,
271-286.
Kell, D.B., Westerhoff, H.V., Fell, D., Thomas, S. & Mendes, P.
(1993) Demonstration programs illustrating the modelling of
metabolic systems [meeting report], Binary 5, 47-49.
Davey, H.M., Kaprelyants, A.S. & Kell, D.B. (1993) Flow
cytometric analysis, using rhodamine 123, of Micrococcus
luteus at low growth rate in chemostat culture. In Flow
cytometry in microbiology, ed. D. Lloyd, Springer-Verlag,
Heidelberg, pp. 83- 93.
Davey, H.M., Davey, C.L. & Kell, D.B. (1993) On the
determination of the size of microbial cells using flow cytometry.
In Flow cytometry in microbiology, ed. D. Lloyd,
Springer-Verlag, Heidelberg, pp. 49-65.
Kaprelyants, A.S. & Kell, D.B. (1993) The use of 5-cyano-2,3-ditolyl tetrazolium chloride and flow
cytometry for the visualisation of respiratory activity in
individual cells of Micrococcus luteus. J. Microbiol.
Methods. 17, 115-122. |
|
| 1992 |
Sauro, H.M. & Kell, D.B.
(1992) Evaluation of steady-state
kinetic parameters of metabolic pathways using neural networks.
Binary, 4, 189-190.
McShea, A., Woodward, A.M. & Kell, D.B. (1992) Non-linear
dielectric properties of Rhodobacter capsulatus. Bioelectrochem. Bioenerg. 29, 205-214.
Salter, G.J. & Kell, D.B. (1992) Rapid determination, using
dielectric spectroscopy, of the toxicity of organic solvents to
intact cells. In Fundamentals of biocatalysis in non-
conventional media, ed. J. Tramper, M.H. Vermüe,
H.H.
Beeftink & U. von Stockar, pp. 291-297. Elsevier,
Amsterdam.
Goodacre, R., Kell, D.B. & Bianchi, G. (1992) Neural
networks and olive oil. Nature 359, 594.
Kell, D.B. & Davey, C.L. (1992) On
fitting
dielectric spectra using artificial neural networks.
Bioelectrochem. Bioenerg. 28, 425-434.
Davey, C.L., Davey, H.M. & Kell, D.B. (1992) On
the dielectric properties of cell suspensions at high volume
fractions. Bioelectrochem. Bioenerg. 28, 319-340.
Peñaloza, W., Davey, C.L., Hedger, J.N. & Kell, D.B.
(1992) Physiological
studies on the quinoa tempe fermentation, using on-line
measurements of fungal biomass production. J. Sci. Food
Agric.,
59, 227-235.
Salter, G.J. & Kell, D.B. (1992) New materials and technology
for cell immobilisation. Current Opinion in Biotechnology, 3,
115-118. Abstract.
Kell, D.B. (1992) Biophysics for the next century, in G.
Arcidiacono, U. Bartocci & M. Mamone Capria (eds.) What
physics for the next century?, p. 17. Società
Editrice
Andromeda, Bologna.
Kell, D.B. (1992) The
protonmotive
force as an intermediate in electron transport-linked
phosphorylation: problems and prospects. Curr. Top. Cell.
Reg.,
33, 279-289.
Kell, D.B. (1992) "Scanning
Tunnelling Microscopy" in biology; are the current carriers
tunnelling electrons or hydrated protons? Bioelectrochem.
Bioenerg., 27, 235-237.
Kaprelyants, A.S. & Kell, D.B. (1992) Rapid assessment of
bacterial viability and vitality using rhodamine 123 and flow
cytometry. J. Appl. Bacteriol., 72, 410-422.
Kell, D.B., Davey, C.L. & Todd, R.W. (1992) Real-time
measurement of cellular biomass using dielectric spectroscopy. In. Biotechnology
International,
2nd Edition (R.N. Greenshields,
ed), pp. 294-297, publ. Grosvenor Press, London.
Kell, D.B. & Woodward, A.M. (1992) Analysis of biological
material by a nonlinear dielectric spectrum. UK Patent 2 247 530
(granted 4.5.94).
Mendes, P., Kell, D.B. & Westerhoff, H.V. (1992) Channelling
can decrease pool size. Eur. J. Biochem., 204, 257-266. Abstract. |
|
| 1991 |
Westerhoff, H.V., van Heeswijk,W.,
Kahn, D. & Kell, D.B.
(1991) Quantitative
approaches to the analysis of the control and regulation of
microbial metabolism. Antonie. van Leeuwenhoek 60, 193-207. Abstract.
Kell, D.B., Ryder, H.M., Kaprelyants, A.S. & Westerhoff, H.V.
(1991) Quantifying
heterogeneity: flow cytometry of bacterial cultures. Antonie
van Leeuwenhoek 60, 145-158. Abstract.
Woodward, A.M. & Kell, D.B. (1991) On
the relationship between the nonlinear dielectric properties and
respiratory activity of the obligately aerobic bacterium Micrococcus
luteus. Bioelectrochem. Bioenerg. 26,
423-439.
Woodward, A.M. & Kell, D.B. (1991) Confirmation
using mutant strains that the membrane-bound H+-ATPase
is the major source of nonlinear dielectricity in Saccharomyces
cerevisiae. FEMS Microbiol. Lett., 84, 91-96. Abstract.
Kell, D.B. & Woodward, A.M. (1991) Nonfaradaic electrochemical
sensors: principles and practice. Anal. Proc., 28, 378-379.
Markx, G.H., Davey, C.L., Kell, D.B. & Morris, P. (1991) The
dielectric permittivity at radio frequencies and the Bruggeman
probe: novel techniques for the on-line determination of biomass
concentrations in plant cell cultures. J. Biotechnol. 20,
279-290.
Kell, D.B. (1991) On
the physiological significance of metabolic channelling; if, how
and when, but not why. J. Theoret. Biol., 152, 49-51.
Kell, D.B. & Welch, G.R. (1991) No turning back: reductionism
and biological complexity. Times Higher Educational Supplement, 9th
August, p. 15. pdf
of
manuscript.
Woodward, A.M. & Kell, D.B. (1991) Dual-frequency
excitation: a novel method for probing the nonlinear dielectric
properties of biological systems, and its application to
suspensions of S. cerevisiae. Bioelectrochem. Bioenerg.,
25, 395-413.
Kell, D.B. (1991) Bioinstrumentation: research, development and
applications [book review]. SGM Quarterly 18, 67.
Salter, G.J. & Kell, D.B. (1991) New
materials and technology for cell immobilisation. Current
Opinion in Biotechnology, 2, 385-389. Abstract.
Kell, D.B. (1991) Paying for the privilege. [Technology Transfer in
Japan and the UK] Times Higher Educational Supplement, June 26, p.
VI.
Markx, G.H., Davey, C.L. & Kell, D.B. (1991) To
what
extent is the value of the Cole-Cole a of the β-dielectric
dispersion of cell suspensions accountable in terms of the cell
size distribution? Bioelectrochem. Bioenerg. 25, 195-211.
Peñaloza, W., Davey, C.L., Hedger, J.N. & Kell, D.B.
(1991) Stimulation
by potassium of the growth of Rhizopus oligosporus during
liquid- and solid-substrate fermentations. World J.
Microbiol.
Biotechnol, 7, 260-268.
Davey, C.L., Peñaloza, W., Kell, D.B. & Hedger, J.N.
(1991) Real-
time monitoring of the accretion of Rhizopus oligosporus biomass during the solid-substrate tempe fermentation. World
J.
Microbiol. Biotechnol, 7, 248-259.
Kell, D.B. (1991) Lacuna
seeker [letter]. Nature 350, 268. Kell, D.B. (1991) Biosensor
Technology: Fundamentals and Applications. : R.P. Buck,
E.F. Bowden, M. Umaña and W.E. Hatfield
(Editors). Marcel Dekker, New York, 1990[BOOK
REVIEW]
Markx, G.H., Davey, C.L. & Kell, D.B. (1991) The permittistat:
a novel type of turbidostat. J. Gen. Microbiol., 137, 735-743.
|
|
| 1990 |
Kell, D.B. (1990) Solutions, but no
answers [book review].
Trends Biochem. Sci. 16, 164.
Kell, D.B. (1990) Determination of biomass. U.S. Patent # 4, 965,
206 of October 23rd.
Woodward, A.M. & Kell, D.B. (1990) On
the
nonlinear dielectric properties of biological systems. Saccharomyces
cerevisiae. Bioelectrochem. Bioenerg., 24,
83- 100.
Markx, G.H. & Kell D.B. (1990) Dielectric spectroscopy as a
tool for the measurement of the formation of biofilms and of their
removal by electrolytic cleaning pulses and biocides. Biofouling,
2, 211-227.
Davey, C.L., Kell, D.B. & Dixon, N.M. (1990) SKATFIT: A program
for determining the mode of growth of individual microbial cells
from flow cytometric data. Binary, 2, 127-132.
Davey, C.L., Dixon, N.M. & Kell, D.B. (1990) FLOWTOVP: a
spreadsheet method for linearising flow cytometric light-scattering
data used in cell sizing. Binary, 2, 119-125.
James, E.W., Dixon, N.M., Denholm, A.M., Kell, D.B. & Morris,
J.G. (1990) Electromicrobial and related approaches to anaerobic
biotransformations. In: Opportunities in Biotransformations (L.G. Copping, R.E. Martin, J.A. Pickett, C. Bucke & A.W.
Bunch, eds.), pp. 195-202. Elsevier Applied Science, London.
Kell, D.B. & Davey, C.L. (1990) Conductimetric and Impedimetric
Devices. In: Biosensors: a practical approach (A.E.G. Cass,
ed.), IRL Press, Oxford, pp. 125- 154.
Ferris, L.E., Davey, C.L. & Kell, D.B. (1990) Evidence
from its
temperature- dependence that the β-dielectric dispersion of
cell
suspensions is not due solely to the charging of a static membrane
capacitance. Eur. Biophys. J., 18, 267-276.
Davey, C.L., Markx, G.H. & Kell, D.B. (1990) Substitution
and spreadsheet methods for analysing dielectric spectra of
biological systems. Eur. Biophys. J., 18, 255-265.
Kell, D.B. & Westerhoff, H.V. (1990) Metabolic control
analysis: theory and practice. In: Mixed and multiple
substrates
and feedstocks, ed. G. Hamer, T. Egli & M. Snozzi,
pp.107-119, Hartung-Gorre, Konstanz.
Kell, D.B., Markx, G.H., Davey, C.L. & Todd, R.W. (1990) Real-time
monitoring of cellular biomass: methods and applications. Trends Anal. Chem., 9, 190-194.
Salter, G.J., Kell, D.B., Ash, L.A., Adams, J.M., Brown, A.J. &
James, R. (1990) Hydrodynamic deposition: a novel method of cell immobilisation. Enz. Micr. Technol., 12, 419-430. Abstract.
Markx, G.H., Davey, C.L., Todd, R.W. & Kell, D.B. (1990) The
real time measurement of biomass accretion using dielectric
spectroscopy. In: Practical advances in fermentation
technology, Institution of Chemical Engineers, North Western
Branch, Symposium Papers No 3, pp. 5.1-5.9.
Davey, C.L. & Kell, D.B. (1990) The dielectric properties of
cells and tissues: what can they tell us about cellular physiology
and the mechanisms of field/cell interactions? In: Emerging
Electromagnetic Medicine (ed. M.E. O'Connor, R.H.C. Bentall
& J.C. Monahan). Springer-Verlag, New York., pp. 19-43.
Kell, D.B. & Westerhoff, H.V. (1990) Control analysis of
organised multienzyme systems. In: Structural and
organizational
aspects of metabolic regulation, UCLA Symposia on Molecular
and
Cellular Biology, New Series, Vol 134 (P. Srere, M.E. Jones &
C. Mathews, eds), pp. 273-289. Alan R. Liss, New York. |
|
| 1989 |
Dixon, N.M. & Kell, D.B.
(1989) The
control and measurement of "CO2" during
fermentations. J. Microbiol. Methods, 10, 155- 176. Walter,
R.P., Kell, D.B., Morris, J.G., James, R. & Adams, J.M. (1989) Catalytic
activity of Candida cylindracea lipase immobilised
on
ceramic supports. Biotechnol. Tech., 3, 345-348.
Stoicheva, N., Davey, C.L., Markx, G.H. & Kell, D.B. (1989) Dielectric
spectroscopy: a rapid method for the determination of solvent
biocompatibility during biotransformations. Biocatalysis 2,
245-255.
Dixon, N.M. & Kell, D.B. (1989) The
inhibition
by CO2 of the growth and metabolism of
microorganisms. J. Appl. Bacteriol., 67, 109-136.
Dixon, N.M., James, E.W., Lovitt, R.W. & Kell, D.B. (1989) Electromicrobial
transformations using the pyruvate synthase system of Clostridium
sporogenes.
Bioelectrochem. Bioenerg. 21,
245-259.
Kell, D.B. (1989) Biosensors [book review] Bioelectrochem.
Bioenerg. 21, 110-111.
Kell, D.B. (1989) Window
boxes? [letter] Nature 338, 612.
Kell, D.B. & Todd, R.W. (1989) Determination of Biomass. US
Patent # 4,810,650 of March 7th.
Davey, C.L. & Kell, D.B. (1989) Low-frequency dielectric
properties of cell suspensions. In: Electric Field Phenomena
in
Biological Systems (R. Paris, ed.) Institute of Physics Short
Meetings 21, 51-63. IOP Publishing, Bristol.
Kell, D.B., van Dam, K. & Westerhoff, H.V. (1989) Control
analysis
of microbial growth and productivity. Symp. Soc. Gen.
Microbiol. 44, 61-93.
|
|
| 1988 |
Westerhoff, H.V., Kell, D.B., Kamp,
F. & van Dam, K. (1988)
The membranes involved in proton-mediated free-energy transduction:
thermodynamic implications of their physical structure. In: Microcompartmentation (D.P.
Jones, ed.) CRC Press, Boca
Raton, pp. 115-154.
Westerhoff, H.V., Astumian, R.D. & Kell, D.B. (1988) Mechanisms
for the interaction between nonstationary electric fields and
biological systems. II. Nonlinear dielectric theory and free-energy
transduction. Ferroelectrics 86, 79-101.
Kell, D.B., Astumian, R.D. & Westerhoff, H.V. (1988) Mechanisms
for the interaction between nonstationary electric fields and
biological systems. I. Linear dielectric theory and its
limitations. Ferroelectrics 86, 59-78.
Davey, C.L., Kemp, R.B., Meredith, R.W.J. & Kell, D.B. (1988) On
the
audio- and radio-frequency dielectric behaviour of
anchorage-independent, mouse L929-derived LS fibroblasts. Bioelectrochem. Bioenerg. 20, 83-98.
James, E.W., Kell, D.B., Lovitt, R.W. & Morris, J.G. (1988) Electrosynthesis
and electroanalysis using Clostridium sporogenes. Bioelectrochem. Bioenerg. 20, 21- 32.
Kell, D.B. (1988) Biosensors: fundamentals and applications [book
review]. Bioelectrochem. Bioenerg. 19, 589.
Dixon, N.M., Lovitt, R.W., Morris, J.G. & Kell, D.B. (1988) Growth energetics of Clostridium sporogenes NCIB 8053:
modulation by
CO2. J. Appl. Bacteriol. 65, 119-134.
Kell, D.B. (1988) Protonmotive energy-transducing systems: some
physical principles and experimental approaches. In: Bacterial
Energy Transduction (C.J. Anthony, ed.), pp. 429-490.
Academic
Press, London.
Westerhoff, H.V., Kell, D.B. & Astumian, R.D. (1988) The dynamics of electrostatic interactions between membrane
proteins. J. Electrostatics 21, 257-298.
Kell, D.B. (1988) Electronic measurement of cellular biomass.
Trends in Biotechnol. 6, 268-269.
Adams, J.M., Ash, L.A., Brown, A.J., James, R., Kell, D.B., Salter
G.J. & Walter, R.P. (1988) A range of ceramic biosupports. Int.
Biotechnol. Lab. 6 (3), 22-27.
Kell, D.B. (1988) A theoretical treatise [Book Review]. Trends
Biochem. Sci. 13, 406.
Pugh, S.Y.R., James, E.W., Kell, D.B. & Morris, J.G. (1988)
Biotransformations Club Report: Cofactor recycling during
biotransformations, 35pp. Laboratory of the Government
Chemist.
Kell, D.B. (1988) Coherent properties of energy-coupling membrane
systems. In: Biological Coherence and Response to External
Stimuli (H. Fröhlich, ed.). Springer, Heidelberg,
pp.
233-241.
Westerhoff, H.V. & Kell, D.B. (1988) A control theoretical
analysis of inhibitor titrations of metabolic channelling. Comments
Mol. Cell. Biophys. 5, 57-107.
Kell, D.B. (1988) Dielectric Spectroscopy of Biological Systems.
In: ISI Atlas of Science: Biochemistry. Vol 1, 25-29. Institute for
Scientific Information, Philadelphia. |
|
| 1987 |
Kell, D.B. (1987) Energetics of
Microbial Growth [book review].
Q. Rev. Biol. 62, 443-444.
Lovitt, R.W., James, E.W., Kell, D.B. & Morris, J.G. (1987)
Bioelectrochemical transformations catalysed by Clostridium
sporogenes, In: Bioreactors and Biotransformations (G.W.
Moody & P.B. Baker, eds) pp.263-276. Elsevier Applied Science
Publishers, London.
Dixon, N.M., Lovitt, R.W., Kell, D.B. & Morris, J.G. (1987) Effects of pCO2 on the growth and metabolism of Clostridium
sporogenes NCIB
8053 in defined media. J. Appl.
Bacteriol. 63, 171-182.
Kell, D.B. (1987) Non-thermally excited modes and free energy
transduction in proteins and biological membranes. In: Energy
Transfer Dynamics (T.W. Barrett & H.A. Pohl, eds),
pp.
237-246. Springer, Heidelberg.
Kell, D.B. (1987) Forces, fluxes and the control of microbial
growth and metabolism. The twelfth Fleming lecture. J. Gen.
Microbiol. 133, 1651-1665.
Westerhoff, H.V. & Kell, D.B. (1987) Matrix
method for determining the steps most rate-limiting to metabolic
fluxes in biotechnological processes. Biotechnol. Bioeng. 30,
101- 107.
in Nielsen, J. (2009) Vintage
Paper: Quantification of Flux Control in Metabolic Pathways. Biotechnol. Bioeng. 104, No.1, 3-9.
Pethig, R. & Kell, D.B. (1987) The
passive
electrical properties of biological systems: their role in
physiology, biophysics and biotechnology. Phys. Med. Biol.
32,
933-970.
Kell, D.B., Samworth, C.M., Todd, R.W., Bungard, S.J. & Morris,
J.G. (1987) Real-time
estimation of microbial biomass during fermentations, using a
dielectric probe. Studia Biophys. 119, 153-156.
Kell, D.B. (1987) The principles and potential of electrical
admittance spectroscopy: an introduction. In: Biosensors;
fundamentals and applications (A.P.F.Turner, I.Karube
&
G.S. Wilson, eds.), pp. 427-468. Oxford University Press.
Kell, D.B. (1987) Bioelectrochemical phenomena: their role and
exploitation in science and technology. University of Wales Rev.
Sci. Technol. 1, 64-71.
Walter, R.P., Kell, D.B. & Morris, J.G. (1987) The roles of
osmotic stress and water activity in the inhibition of the growth,
glycolysis and glucose phosphotransferase system of Clostridium
pasteurianum. J. Gen. Microbiol. 133, 259-266. Abstract.
Lovitt, R.W., Morris, J.G. & Kell, D.B. (1987) The growth and
nutrition of Clostridium sporogenes NCIB 8053 in
defined
media. J. Appl. Bacteriol. 62, 71- 80. Abstract.
Lovitt, R.W., Kell, D.B. & Morris, J.G. (1987) The physiology
of Clostridium sporogenes NCIB 8053 growing in
defined
media. J. Appl. Bacteriol. 62, 81-92. Abstract.
Harris, C.M., Todd, R.W., Bungard, S.J., Lovitt, R.W., Morris, J.G.
& Kell, D.B. (1987) The dielectric permittivity of microbial suspensions at radio
frequencies: a novel method for the real-time estimation of
microbial biomass. Enz. Micr. Technol. 9, 181-186. |
|
| 1986 |
Symons, M.R., Korenstein, R., Harris,
C.M. & Kell, D.B.
(1986) Dielectric
properties of energy coupling membranes: chloroplast
thylakoids. Bioelectrochem. Bioenerg. 16, 45-54.
Kell, D.B. & Walter, R.P. (1986) Organisation and control of
energy metabolism in anaerobic microorganisms. In: The
Organisation of Cell Metabolism (G.R. Welch & J.S.
Clegg,
eds.), pp. 215-231. Plenum Press, New York.
Kell, D.B. (1986) On the lateral mobility of proteins in
prokaryotic membranes. Biochem. Soc. Trans. 14, 825-826.
Harris, J., Mulder, R., Kell, D.B., Walter, R.P. & Morris, J.G.
(1986) Solvent
production by Clostridium pasteurianum in media of
high
sugar content. Biotechnol. Lett. 8, 889-892.
Lovitt, R.W., Kell, D.B. & Morris, J.G. (1986) Proline
reduction by Clostridium sporogenes is coupled to
vectorial
proton ejection. FEMS Microbiol. Lett. 36, 269- 273.
Kell, D.B. (1986) Uncoupler
titrations in co-reconstituted systems do not discriminate between
localized and delocalized mechanisms of photophosphorylation. Biochem. J. 236, 931-932.
Kell, D.B. & Westerhoff, H.V. (1986) Towards
a rational approach to the optimization of flux in microbial
biotransformations. Trends in Biotechnol. 4, 137-142.
Kell, D.B. & Westerhoff, H.V. (1986) Metabolic
control theory: its role in microbiology and biotechnology. FEMS Microbiol. Rev. 39, 305-320.
Kell, D.B. (1986) Foreword. In: Modern Bioelectrochemistry (F. Gutmann & H. Keyzer, eds.) pp. x-xi. Plenum Press, New
York.
Harris, C.M. & Kell, D.B. (1986) Dielectric Spectroscopy of
protein translational diffusion in prokaryotic membranes. Bioelectrochem. Bioenerg. 15, 183-184.
Welch, G.R. & Kell, D.B. (1986) Not just catalysts; the
bioenergetics of molecular machines. In: The Fluctuating
Enzyme (G.R. Welch, ed.), pp. 451-492. Wiley, New York.
Kell, D.B. (1986) Localized
protonic coupling: overview and critical evaluation of
techniques. Meth. Enzymol. 127, 538-557.
Kell, D.B. & Burns, A. (1986) A nomograph for calculating the
optimal frequency for dielectrophoresis and the characteristic
frequency of the β-dispersion of cell membrane
vesicles. J. Bioelectricity, 5, 139-144.
Lovitt, R.W., Walter, R.P., Morris, J.G. & Kell, D.B. (1986) Conductimetric assessment of the biomass content in suspensions of
immobilised (gel-entrapped) microorganisms. Appl. Microbiol.
Biotechnol., 23, 168-173. |
|
| 1985 |
Kell, D.B. & Harris, C.M.
(1985) Dielectric spectroscopy
and membrane organisation. J. Bioelectricity, 4, 317-348.
Kell, D.B. (1985) The
electric
microbe acid test [book review]. Trends Biotechnol. 3,
153-154.
Harris, C.M. & Kell, D.B. (1985) On the dielectrically
observable consequences of the diffusional motions of lipids and
proteins in membranes. 2. Experiments with microbial cells,
protoplasts and membrane vesicles. Eur. Biophys. J. 13, 11-24. Abstract.
Kell, D.B. & Harris, C.M. (1985) On the dielectrically
observable consequences of the diffusional motions of lipids and
proteins in membranes. 1. Theory and overview. Eur. Biophys. J. 12,
181-197. Abstract.
Phillips, M.K., Rhodes-Roberts, M.E. & Kell, D.B. (1985) Tinopal AN as a selective agent for the differentiation of
phytopathogenic and saprophytic Pseudomonas species. J.
Appl. Bacteriol. 58, 283-292.
Harris, C.M. & Kell, D.B. (1985) The estimation of microbial biomass. Biosensors J. 1, 17-84. Abstract.
Kell, D.B. (1985) Proton transport and cellular energetics. In: Proc.
UNESCO Conference on Biophysical
Correlates of Cellular
Function (C.F. Hazlewood, ed.), pp. 52- 59. Houston.
Kell, D.B. & Westerhoff, H.V. (1985) Catalytic facilitation and
membrane bioenergetics. In: Organized Multi-enzyme Systems:
Catalytic Properties (G.R. Welch, ed.), pp. 63-139. Academic
Press, New York. |
|
| 1984 |
Westerhoff, H.V., Melandri, B.A.,
Venturoli, G., Azzone, G.F.
& Kell, D.B. (1985) A
minimal hypothesis for membrane-linked free-energy transduction:
the role of independent, small coupling units. Biochim.
Biophys. Acta 768, 257-292. Abstract. Hitchens, G.D. & Kell, D.B. (1984) On the effects of thiocyanate and venturicidin on
respiration-driven proton translocation in Paracoccus
denitrificans. Biochim. Biophys. Acta 766, 222-232. Abstract.
Kell, D.B. (1984) Constraints on the lateral diffusion of membrane proteins in
prokaryotes. Trends Biochem. Sci. 9, 379.
Phillips, M.K., Rhodes-Roberts, M.E. & Kell, D.B. (1984) The
anti-bacterial action of Tinopal AN. J. Gen. Microbiol. 130,
1999-2005. Abstract.
Kell, D.B. (1984) Diffusion of protein complexes in prokaryotic membranes: fast,
free, random or directed? Trends Biochem. Sci. 9, 86-88.
Kell, D.B. (1984) Dielectric spectroscopy of the rotational and
translational motions of membrane proteins: theory and experiment.
EBEC Reports 3, 645-646.
Hitchens, G.D. & Kell, D.B. (1984) Effects of thiocyanate and
venturicidin on respiration-driven H+ translocation in Paracoccus denitrificans.
EBEC Reports 3, 243-244.
Kell, D.B. & Hitchens, G.D. (1984) Proton transfer pathways
during bacterial electron transport phosphorylation. Biochem. Soc.
Trans. 12, 413-414.
Westerhoff, H.V., Melandri, B.A., Venturoli, G., Azzone, G.F. &
Kell, D.B. (1984) Mosaic
protonic coupling hypothesis for free energy transduction. FEBS
Lett. 165, 1-5.
Harris, C.M., Hitchens, G.D. & Kell, D.B. (1984) Dielectric
properties of microbial membrane systems. In: Charge and
Field
Effects in Biosystems (M.J.Allen & P.N.R. Usherwood,
eds.),
pp. 179-185. Abacus Press, Tunbridge Wells.
|
|
| 1983 |
Kell, D.B. (1983) Coupling factor B
and the bovine
mitochondrial H+-ATP synthase. Trends Biochem.
Sci. 8, 153-154.
Kell, D.B. (1983) Dielectric properties of bacterial chromatophores. Bioelectrochem. Bioenerg. 11, 405-415.
Melandri, B.A., Azzone, G.F., Kell, D.B., Venturoli, G. &
Westerhoff, H.V. (1983) Is the transmembrane proton potential
difference a competent intermediate in membrane- associated ATP
synthesis? Proc. 6th Int. Congr. Photosynthesis, Brussels.
Keilmann, F. & Kell, D.B. (1983) Coherent excitation in biology. Nature 301, 656-657.
Harris, C.M. & Kell, D.B. (1983) The
radio-frequency dielectric properties of yeast cells measured with
a rapid, automated, frequency-domain dielectric spectrometer. Bioelectrochem. Bioenerg. 11, 15-28.
Kell, D.B. & Hitchens, G.D. (1983) Coherent properties of the
membranous systems of electron transport phosphorylation. In: Coherent
Excitations in Biological
Systems (H. Fröhlich
& F. Kremer, eds.), pp. 178-198. Springer, Berlin &
Heidelberg.
Hitchens, G.D. & Kell, D.B. (1983) On
the functional unit of energy coupling in photophosphorylation by
bacterial chromatophores. Biochim. Biophys. Acta 723,
308-316.
Hitchens, G.D. & Kell, D.B. (1982) Uncouplers
can shuttle rapidly between localised energy coupling sites during
photophosphorylation by chromatophores of Rhodopseudomonas
capsulata N22. Biochem. J. 212, 25-30. Abstract.
|
|
| 1982 |
Phillips MK, Kell DB: A novel inhibitor of NADH dehydrogenase in Paracoccus denitrificans. FEBS Lett 1982; 140:248-250.
Kell, D.B. & Hitchens, G.D.
(1982) Proton-coupled
energy transduction by biological membranes: principles, pathways
and praxis. Disc. Faraday Soc. 74, 377-388.
Clarke, D.J., Kell, D.B., Morris, J.G. & Burns, A. (1982) The
role of ion-selective electrodes in microbial process control.
Ion-Selective Electrode Rev. 4, 75-131.
Kell, D.B. (1982) A rose by any other name. Trends Biochem. Sci 7,
420.
Kell, D.B. (1982) Enzymes as energy 'funnels'? Trends Biochem. Sci. 7, 349.
Kell, D.B. & Morris, J.G. (1982) On the role of interfacial
water in protonmotive systems. In: Biophysics of Water (F.
Franks & S.F. Mathias, eds.), pp. 137-139. Wiley,
Chichester.
Hitchens, G.D. & Kell, D.B. (1982) Localised
energy coupling during photophosphorylation by chromatophores of Rhodopseudomonas
capsulata N22. Biosci. Rep. 2, 743-749. Abstract.
Kell, D.B. (1982) Bacteria
that are resistant to uncouplers: what can they tell us? Trends
Biochem. Sci. 7, 1-2.
Hitchens, G.D., Kell, D.B. & Morris, J.G. (1982) Transmembrane
respiration-driven proton translocation is unimpaired in an eup mutant of Escherichia
coli. J. Gen. Microbiol.
128, 2207-2209.
Hitchens, G.D. & Kell, D.B. (1982) Respiration-driven H+ translocation in Paracoccus denitrificans: role of
the
'permeant' ion. Biochem. Soc. Trans. 10, 261.
Kell, D.B. & Hitchens, G.D. (1982) Respiration-driven proton
translocation in Paracoccus denitrificans: role of
the
'permeant' ion. EBEC Reports 2, 395-396.
Clarke, D.J., Morley, C.D., Kell, D.B. & Morris, J.G. (1982) On
the
mode of action of the bacteriocin butyricin 7423: effects on
membrane potential and potassium ion accumulation in Clostridium
pasteurianum. Eur. J. Biochem. 127, 105-116. Abstract.
Hitchens, G.D. & Kell, D.B. (1982) On
the
extent of localization of the energized membrane state in
chromatophores from Rhodopseudomonas capsulata N22. Biochem. J. 206, 351-357. Abstract.
Phillips, M.K. & Kell, D.B. (1982) A novel inhibitor of NADH
dehydrogenase in Paracoccus denitrificans. FEBS
Lett. 140,
248- 250. |
|
| 1981 |
Clarke, D.J., Kell, D.B., Morley,
C.D. & Morris, J.G.
(1981) Butyricin 7423 and the membrane H+-ATPase
of Clostridium pasteurianum.
Arch. Microbiol. 131, 81- 86. Abstract.
Kell, D.B. (1981) Are liposomes good models for biomembranes?
Trends Biochem. Sci. 6, 8-9.
Vignais, P.M., Henry, M-F., Sim, E. & Kell, D.B. (1981) The
electron transport system and hydrogenase of Paracoccus
denitrificans. Curr. Top. Bioenerg. 12, 115- 196.
Kell, D.B. & Morris, J.G. (1981) Proton-coupled membrane energy
trannsduction: pathways, mechanisms and control. In: Vectorial
reactions in Electron and Ion Transport in Mitochondria and
Bacteria (F. Palmieri, E. Quagliariello, N. Siliprandi
&
E.C. Slater, eds.), pp. 339-347. Elsevier/North Holland,
Amsterdam.
Kell, D.B., Peck, M.W., Rodger, G. & Morris, J.G. (1981) On
the permeability to weak acids and bases of the cytoplasmic
membrane of Clostridium pasteurianum. Biochem. Biophys.
Res. Comm. 99, 81-88.
Phillips, M.K. & Kell, D.B. (1981) A benzoxazole inhibitor of NADH dehydrogenase in Paracoccus
denitrificans. FEMS Microbiol. Lett. 11,111-113.
Kell, D.B., Doddema, H.J., Morris, J.G. & Vogels, G.D. (1981)
Energy coupling in methanogens. In: Microbial Growth on C1
Compounds (H. Dalton, ed.) pp. 159-170. Heyden, London.
Clarke, D.J., White, N.J.M., Burns, A., Kell, D.B. & Morris,
J.G. (1981) A flexible, microprocessor-directed fermentation system
for the control of hardware and monitored parameters. Proc. 2nd
Eur. Congr. Biotechnol. p. 145. Society for Chemical Industry,
London.
Kell, D.B., Burns, A., Clarke, D.J. & Morris, J.G. (1981)
Proteinaceous proton pumps: a minimal model, some properties and
their possible universality. Specul. Sci. Technol. 4, 109-120.
Kell, D.B., Clarke, D.J. & Morris, J.G. (1981) On
proton-coupled information transfer along the surface of biological
membranes and the mode of action of certain colicins. FEMS
Microbiol. Lett. 11, 1-11.
McCarthy, J.E.G., Ferguson, S.J. & Kell, D.B. (1981) Estimation
with an ion-selective electrode of the membrane potential in cells
of Paracoccus denitrificans from the uptake of the
butyl
triphenylphosphonium cation during aerobic and anaerobic
respiration. Biochem. J. 196, 311-321. Abstract.
Smyth, M.R. & Kell, D.B. (1981) Polarographic investigation of
some cytokinins. J. Electroanal. Chem. 122, 363-365.
Kell, D.B. & Griffiths, A.M. (1981) Polarographic assay of the
binding of certain probe' molecules to bacteriorhodopsin sheets.
Photobiochem. Photobiophys. 2, 105-110. |
|
| 1980 |
Kell, D.B. & Morris, J.G.
(1980) Formulation
and some biological properties of a buffer mixture whose buffering
capacity is relatively independent of pH in the range pH 4 to pH
9. J. Biochem. Biophys. Methods 3, 143-150. Abstract.
Doddema, H.J., Claesen, C.A., Kell, D.B., van der Drift, C. &
Vogels, G.D. (1980) An
adenine
nucleotide translocase in the procaryote Methanobacterium
thermoautotrophicum. Biochem. Biophys. Res. Comm.
95,
1288-1293.
Kell, D.B. & Griffiths, A.M. (1980) The 'energised state' in
bacteriorhodopsin sheets. EBEC Reports 1, 423-424.
Kell, D.B. (1980) The optimisation of detector systems
incorporating ion-selective electrodes. In: Electroanalysis
in
Hygiene, Environmental, Clinical and Pharaceutical Chemistry (W.F. Smyth, ed.), pp 61-77. Elsevier, Amsterdam.
Kell, D.B. (1980) The role of ion-selective electrodes in improving
fermentation yields. Process Biochemistry 15(1), 18-23, 29. |
|
| 1979 |
Kell, D.B. & Morris, J.G.
(1979) Oxidation-reduction
properties of coenzyme M (2- mercaptoethane sulphonate) at the
mercury electrode. FEBS Lett. 108, 481-484.
Ferguson, S.J., Sorgato, M.C., Kell, D.B. & John, P. (1979)
Comparative aspects of the energetics of oxidative phosphorylation
in bacteria and mitochondria. Biochem. Soc. Trans. 7, 870-874.
Clarke, D.J., Kell, D.B. & Morris, J.G. (1979) The generation
of a membrane potential by a fermentative bacterium. Biochem. Soc.
Trans. 7, 1111-1112.
Ferguson, S.J., Jones, O.T.G., Kell, D.B. & Sorgato, M.C.
(1979) Comparison of permeant ion uptake and carotenoid band shift as
methods for determining the membrane potential in chromatophores
from Rhodopseudomonas sphaeroides Ga. Biochem. J. 180,
75-85. Abstract.
Kell,
D.B. (1979) On
the
functional proton current pathway of electron transport
phosphorylation: an electrodic view. Biochim. Biophys. Acta
549, 55-99.
Ferguson, S.J., Gadian, D.G. & Kell, D.B. (1979) Evidence from
31P nuclear magnetic resonance that polyphosphate synthesis is a
slip reaction in Paracoccus denitrificans. Biochem.
Soc.
Trans. 7, 176-179. |
|
| 1978 |
Sorgato, M.C., Ferguson, S.J.
& Kell, D.B. (1978) On the
current-voltage relationships of energy-transducing membranes:
submitochondrial particles. Biochem. Soc. Trans. 6, 1301- 1302.
Kell, D.B., John, P. & Ferguson, S.J. (1978) On the current-
voltage relationships of energy-transducing membranes:
phosphorylating membrane vesicles from Paracoccus
denitrificans. Biochem. Soc. Trans. 6, 1292-1295.
Kell, D.B., Ferguson, S.J. & John, P. (1978) Measurement by a flow dialysis technique of the steady-state
protonmotive force in chromatophores from Rhodospirillum
rubrum: comparison with the phosphorylation potential. Biochim. Biophys. Acta 502, 111-126. Abstract.
Sorgato, M.C., Ferguson, S.J., Kell, D.B. & John, P. (1978) The
protonmotive force in bovine heart submitochondrial particles:
magnitude, sites of generation and comparison with the
phosphorylation potential. Biochem. J. 174, 237-256. Abstract.
Kell, D.B., John, P. & Ferguson, S.J. (1978) The
protonmotive force in phosphorylating membrane vesicles from Paracoccus
denitrificans:
magnitude, sites of generation and
comparison with the phosphorylation potential. Biochem. J.
174,
257-266.
Ferguson, S.J., Kell, D.B. & John, P. (1978) Resolution of Paracoccus denitrificans vesicles of
differing
configuration using affinity chromatography. FEMS Microbiol.
Lett. 3, 151-154.
Kell, D.B., John, P., Sorgato, M.C. & Ferguson, S.J. (1978) Continuous
monitoring of the electrical potential across energy-
transducing membranes using ion-selective electrodes: application
to submitochondrial particles and chromatophores. FEBS Lett.
86, 294-298. |
|
| 1977 |
Kell, D.B. & John, P. (1977)
Studying mitochondria by using
bacteria. ATLA Abstracts 5, 10-11. |
|
| White Papers |
Occasionally we are asked (or choose) to produce position statements on various scientific topics. This section provides access to some of them.
Puplications
Kell, D.B. & Mendes, P. (1999) Snapshots of systems - metabolic control analysis and biotechnology in the post-genomic era. In Technological and Medical Implications of Metabolic Control Analysis (A. Cornish-Bowden and M.L.Cárdenas, ed.) pp. 3-25. Kluwer Academic Publishers, Dordrecht. Ms available in Postscript or pdf versions. See also a draft (pre-meeting) web version.
Knowles, J. & Corne, D. (2004) Memetic Algorithms for Multiobjective Optimization: Issues, Methods and Prospects. In Recent Advances in Memetic Algorithms. Krasnogor,
N., Smith, J.E., and Hart, W.E. (eds). Springer (to appear Autumn 2004).
Handl, J. & Knowles, J. (2004) Evolutionary multiobjective clustering. In Parallel Problem Solving from Nature,
(PPSN VIII). Springer (to appear September 2004).
Presentations
Jones, A. (1996) An Introduction to Multivariate Calibration. Institute of Biological Sciences, University of Wales, Aberystwyth, Dyfed SY23 3DA. |
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